Ukwenziwa kwenzululwazi ukunyanga isifo sentliziyo

Ukwenziwa kwenzululwazi ukunyanga isifo sentliziyo

Kwi-groundbreaking uphando olutsha, izazinzulu ziya kubhala kwakhona i-DNA ngenjongo yokufumana unyango lokuqala lwehlabathi kwi-genetic heart disease, kwinto enokuthi ichazwe "njengomzuzu oqinisekileyo" kwintsimi yeyeza ze-cardiovascular.

Ngokwento epapashwe yiwebhusayithi ye-"Boldsky", izazinzulu ezihamba phambili zehlabathi ezivela e-United Kingdom, e-United States naseSingapore zibambisene kwiprojekthi ethi "Cure Heart" ukuyila isitofu sokugonya izigulane zentliziyo. Ngokweengxelo zeendaba, iBritish Heart Foundation izinikele kwi-30 yezigidi zeedola kule projekthi yokusindisa ubomi.

Ngethuba lokuqala, abaphandi baya kusebenzisa iindlela ezichanekileyo zofuzo, ezaziwa njengokuguqulwa okusisiseko, entliziyweni ukuyila kunye nokuvavanya unyango lokuqala lwezifo ze-muscle zentliziyo, ngenjongo yokuphazamisa i-gene ephosakeleyo.

Isifo sentliziyo esizuzw’ ilifa

“Isifo sentliziyo esizuzwe njengelifa” ligama eliquka zonke izifo zentliziyo ezidluliselwa kubazali zisiya kubantwana babo, oko kukuthi xa omnye okanye bobabini abazali benemfuza enesiphene okanye eguqukileyo, kukho ithuba elingama-50/50 lokuyidlulisela ebantwaneni. Ezinye izifo zentliziyo ezizuzwe njengelifa ziquka i-hypertrophic cardiomyopathy kunye ne-hypercholesterolemia.

Abanye abantu abanesifo senhliziyo yemfuza basenokungabi nazimpawu zininzi, kwaye imeko ayifunyaniswanga de kube semva kokuhlaselwa yintliziyo ngequbuliso, isiqaqa, okanye ukufa ngesiquphe. Ubalo lubonisa ukuba malunga ne-0.8 ukuya kwi-1.2% yabantwana abasanda kuzalwa kwihlabathi jikelele bachatshazelwa sisifo sentliziyo.

Ithuba lembali kunye neminyaka engama-30 yophando

Ikomiti yeengcebiso ekhokelwa nguNjingalwazi uSir Patrick Vallance, umcebisi oyintloko wesayensi kurhulumente waseBrithani, wakhetha iqela elijongene nesifundo esibalulekileyo, ngelixa uNjingalwazi uHugh Watkins, waseYunivesithi yaseOxford kunye nomphenyi oyintloko kwiprojekthi yeCure Heart, wathi i-cardiomyopathy. Sisifo esimandundu.Imeko "exhaphakileyo" kwihlabathi jikelele kwaye yaziwa ukuba ichaphazela umntu om-250 kwabangama-XNUMX.

UNjingalwazi Watkins wongezelela, echaza isifundo "njengethuba lexesha elilodwa-kwisizukulwana" elijolise ekunciphiseni uxhalaba oluqhubekayo malunga nokufa ngokukhawuleza, ukungaphumeleli kwentliziyo kunye nesidingo esinokwenzeka sokutshintshwa kwentliziyo.

Unjingalwazi Watkins wachaza, “Emva kweminyaka engama-30 yophando, uninzi lwemfuza ethile kunye neziphene zofuzo ziye zafunyanwa ezinoxanduva lokwahluka kwe-cardiomyopathy kunye nendlela ezisebenza ngayo. Kukholelwa ukuba kuya kubakho unyango lwemfuza oluza kuqalisa ulingo lwezonyango phakathi kweminyaka emihlanu ezayo.”

Ukulungiswa kwemfuza enesiphene

Kuthenjwa ukuba inkqubo entsha yophando iya kuzilungisa ngokusisigxina iinguqulelo zemfuza ezibangela iingxaki zentliziyo.

Kulo mongo, uChristine Seidman, unjingalwazi kwiSikolo Sezamayeza saseHarvard nomphandi ophambili owayebandakanyekile kulo msebenzi, wachaza ukuba injongo “yayikukulungisa iintliziyo” nokubuyisela ukusebenza kwazo ngokuqhelekileyo, echaza ukuba “uninzi lweenguqulelo eziye zabonakala phakathi kwezigulana ziyakhokela. Ukutshintsha unobumba omnye ngokuphindaphindiweyo.” Ukususela kwiDNA code, nto leyo ethetha ukuba kukho unyango ngokutshintsha imonogram nokubuyisela le khowudi.”

Ngokutsho kwabaphandi, oovulindlela abavela kumazwekazi amathathu kwaye bahluke kwintsimi entsha kunye nechanekileyo yokuhlelwa kwemfuza echaphazelekayo kwisifundo, izilingo zabantu azikaqhutywa, kodwa izilingo zezilwanyana ziye zaphumelela kwaye zithembisa.

Abaphandi bongeze ukuba kunethemba lokuba abantu abasemngciphekweni wokufumana isifo senhliziyo ngenxa yobukho bemfuza engalunganga kwiintsapho zabo baya kuba nakho ukufumana unyango ngaphambi kokuba isifo sabo sikhule.