Ukufumanisa ubudlelwane obusondeleyo phakathi kwamathumbu kunye nengqondo

Ukufumanisa ubudlelwane obusondeleyo phakathi kwamathumbu kunye nengqondo

Ubungqina obukhulayo bubonisa ukuba amashumi eebhiliyoni zee-microbes ezihlala zihlala emathunjini - okubizwa ngokuba yi-gut microbiome - zineziphumo ezide kwindlela umzimba womntu osebenza ngayo. Uluntu lwe-microbial luvelisa iivithamini, lunceda ukugaya ukutya, lukhusela ukukhula kweebhaktheriya ezinobungozi, kwaye lulawula amajoni omzimba, phakathi kwezinye izibonelelo.

Unyango lwe-neurodegeneration

Ngokutsho kwento epapashwe yi "Neuroscience News" ecaphula iphephancwadi elithi "Sayensi", uphando olutsha olwenziwe ngabaphandi abavela kwiYunivesithi yaseWashington School of Medicine eSt. impilo yobuchopho bomntu.

Uphononongo lufumanisa ukuba iibhaktheriya zamathumbu - ngokuyinxenye ngokuvelisa iikhompawundi ezifana ne-short-chain fatty acids - zichaphazela ukuziphatha kweeseli zokuzivikela emzimbeni wonke, kubandakanywa nezo zisengqondweni ezinokonakalisa izicubu zobuchopho kunye nokwandisa i-neurodegeneration kwiimeko ezifana nesifo se-Alzheimer. .

Iziphumo ezitsha zivula iingcango zokuba nokwenzeka kohlengahlengiso lwe-microbiome yamathumbu njengendlela yokuthintela okanye ukunyanga i-neurodegeneration.

Isiphelo esimangalisayo

"Sinike amayeza amancinci eempuku kwiveki nje enye, kwaye sabona utshintsho oluhlala luhleli kwiintsholongwane zabo zamathumbu, iimpendulo zabo zokuzikhusela komzimba, kunye nesixa se-neurodegeneration ehambelana neprotein ebizwa ngokuba yi-tau abayifumanayo njengoko babeguga," utshilo umbhali omkhulu kunye nophando. Unjingalwazi ohloniphekileyo we-Neuroscience, uNjingalwazi uDavid Holtzman.Ukufumanisa okumangalisayo kukuba "ukulawula i-gut microbiome ingaba yindlela yokuchaphazela ingqondo ngaphandle kokubeka nantoni na ngqo kwingqondo."

Ubungqina buyanda bokuba i-gut microbiomes yabantu abanesifo i-Alzheimer's inokwahluka kweyabantu abasempilweni. Kodwa akucaci ukuba lo mahluko ngunobangela okanye sisiphumo sesi sifo-okanye zombini-kwaye yintoni impembelelo eguquliweyo ye-microbiome enokuba nayo ekuhambeni kwesi sifo.

Ukuguqulwa kwemfuzo

Ukufumanisa ukuba i-gut microbiome idlala indima eyimbangela, abaphandi baguqule i-gut microbiomes yeempuku ezibekwe ngaphambili kumonakalo wengqondo njengesifo se-Alzheimer kunye nokuphazamiseka kwengqondo.

Iigundane zenziwe ukuba zibonise uhlobo olutshintshileyo lweprotheyini yengqondo yomntu, eqokelela kwaye ibangele umonakalo we-neuronal kunye ne-atrophy ebuchosheni babo ngeenyanga ze-9.

Baphinde balayisha uhlobo lofuzo lomntu lwe-APOE, eyona nto ingumngcipheko omkhulu wemfuzo kwisifo i-Alzheimer's.Abantu abanekopi enye yomahluko we-APOE4 banamathuba aphindwe kathathu ukuya kwamane okuba baphuhle isifo kunabantu abanolunye uhlobo lwe-APOE3 oluxhaphake kakhulu.

Indlela entsha yokuthintela

"Olu pho nonongo lunokubonelela ngengqiqo ebalulekileyo malunga nendlela i-microbiome echaphazela ngayo i-neurodegeneration ye-tau," watsho uNjingalwazi uLinda McGovern, umlawuli kwi-US National Institute of Neurological Disorders.

Iziphumo zibonisa indlela entsha yokuthintela kunye nokunyanga izifo ze-neurodeergenerative ngokuguqula i-gut microbiome kunye ne-antibiotics, i-probiotics, izidlo ezikhethekileyo, okanye ezinye iindlela.

Ukuqala kwiminyaka ephakathi

Kwelakhe icala, uNjingalwazi Holtzmann uthe iziphumo zicebisa ukuba "unyango lunokuqaliswa kubantu abakwiminyaka ephakathi ngelixa beqhelekile ngokwengqondo kodwa bekwicala lokonakala", ecacisa ukuba ukuba unyango lunokuqaliswa kwiimodeli zezilwanyana zabantu abadala ezinobuthathaka kwi-neurodegeneration. ngaphambi kokuba isifo sibonakale okokuqala, kwaye unyango luboniswa ukuba lusebenza, le nto ingaba yindawo apho iimvavanyo zeklinikhi zabantu zinokuqala.

Izizathu ezinamandla ezikhuthazayo zezifo ze-neurological kunye ne-Alzheimer's