Ukutshaya asikokuphela kwento ebangela umhlaza wemiphunga

Ukutshaya asikokuphela kwento ebangela umhlaza wemiphunga

Ezinye izinto ezingcolisa umoya zibonakala “njengombulali ofihlakeleyo”, njengoko zinokubangela inani lomhlaza wemiphunga kubantu abangatshayiyo, ngendlela echazwa luphononongo olupapashwe ngoMgqibelo, kwaye ukufikelela ekuqondeni kwabo “linyathelo elibalulekileyo kwisayensi kunye nenzululwazi. uluntu,” ngokutsho kweqela leengcali.

Iingcali zenzululwazi ezivela kwiFrancis Crick Institute kunye neYunivesithi yaseLondon yachaza ukuba amaqhekeza amahle (ngaphantsi kwe-2,5 microns, malunga nobubanzi beenwele), eziqwalaselwa phakathi kwezizathu zokutshintsha kwemozulu, zikhokelela ekutshintsheni komhlaza kwiiseli zenkqubo yokuphefumula.

umbulali ofihlakeleyo

Amasuntswana amahle kwiigesi zokukhupha, uthuli oluqhekezayo okanye imfucu evela kumafutha e-fossil angafaniswa "nombulali ofihlakeleyo", watsho uCharles Swanton weFrancis Crick Institute, owanikezela iziphumo zolu phando, olungekahlaziywa ngabanye abaphandi. Ngexesha lenkomfa yonyaka ye-European Society of Medical Oncology, ebanjwe eParis ukuya kwi-13 Septemba.

Ngelixa uNjingalwazi Swanton wakhumbuza ukuba ukulimala kongcoliseko lomoya kuye kwaziwa ixesha elide, waphawula ukuba izazinzulu "zazingaqinisekanga ukuba okanye njani olu ngcoliseko lubangela ngokuthe ngqo umhlaza wemiphunga."

Abaphandi baqale bafunda idatha kubantu abangaphezu kwe-460 abavela eNgilani, eSouth Korea naseTaiwan, kwaye babonisa unxibelelwano phakathi kokuvezwa kokunyuka kwamasuntswana amahle kunye nomngcipheko owongeziweyo womhlaza wemiphunga.

250 iisampulu

Nangona kunjalo, eyona nto iphawulekayo efunyenweyo kukuqonda indlela ezi ngcoliseko ezibangela ngayo umhlaza wemiphunga kubantu abangatshayiyo.

Kuphononongo lwaselabhorethri kwiimpuku, abaphandi babonise ukuba amasuntswana adala utshintsho kuhlobo lwemfuza ezimbini, ezizezi, i-epidermal growth factor receptor (EGFR) kunye neKeras (KRAS), esele inxulunyaniswe nomhlaza wemiphunga.

Emva koko abaphandi bahlalutya malunga neesampulu ze-250 zezicubu zemiphunga yomntu ezinempilo ezingazange zivezwe kwi-carcinogens evela kwicuba okanye kungcoliseko olukhulu. Ukuguqulwa kofuzo kwi-EGFR kuvele kwiipesenti ze-18 zeesampuli, kwaye utshintsho kwi-KRAS kwiipesenti ze-33 zazo.

"imfihlelo"

UNjingalwazi Swanton uthe "olu tshintsho lusenokunganeli ngokwalo ukukhokelela kumhlaza, kodwa xa iseli isesichengeni sosulelo, kunokwenzeka ukuba ivuselele uhlobo oluthile lokusabela" ukudumba. Wongeze ukuba "iseli iya kubangela umhlaza" ukuba "inoguquko."

USwanton, okhokela umxhasi ophambili wolu phando, uPhando loMhlaza e-UK, uthe olu phononongo "yayikukucacisa inkqubo yebhayoloji yento ebiyimfihlakalo."

Kwakukholelwa ukuba ukuchanabeka kwizinto ezibangela umhlaza, ezinjengezo zibangelwa ngumsi wecuba okanye ungcoliseko, kubangela ukuguquka kwemizila yemfuza kwiiseli, kuzenze zibe ngamathumba yaye oko kukhokelela ekwandeni kwazo.

Umlawuli weNkqubo yoThintelo lweCancer kwiGustave Rossi Sozette Delalog Institute yaphawula ukuba iziphumo zophando "luphuhliso loguquko", njengoko "kwakungekho bungqina bangaphambili bolu hlobo lwe-carcinogenesis."

Le oncologist, owathunywa ukuba axoxe ngesifundo ngexesha lenkomfa, wagxininisa ukuba "linyathelo elibalulekileyo kwisayensi", ngethemba lokuba kuya kuba njalo "kuluntu ngokunjalo", kwaye ithathelwe ingqalelo ukuba "ivula umnyango obanzi wolwazi. kodwa nokuthintela.”

Ukunciphisa ungcoliseko lomoya

UNjingalwazi Swanton uthe inyathelo elilandelayo iya kuba “kukuqonda ukuba kutheni ezinye zeeseli zemiphunga ezitshintshiweyo zijika zibe ngumhlaza emva kokuchanabeka kwizinto ezingcolisa umoya”.

Inani labaphandi ligxininise ukuba olu phononongo luqinisekisa ukuba ukunciphisa ungcoliseko lomoya kubalulekile nakwimpilo.

“Sinokukhetha phakathi kokutshaya okanye ukungatshayi, kodwa asinakukhetha umoya esiwuphefumlayo,” utshilo uSwanton. Ngoko ke yingxaki yehlabathi lonke xa kujongwa ukuba inani labantu abachanabeke kumlinganiselo ongeyompilo wongcoliso lisenokuba likhulu ngokuphindwe kahlanu kunabo bachanabeke kumsi wecuba.”

Ngaphezu kwama-90 ekhulwini kubemi behlabathi bachanabeke koko iWorld Health Organization ikuchaza njengomlinganiselo ogqithiseleyo wongcoliso oluqulethe incindi ecolekileyo.