I-China ibonelela ngokukhuseleka kwangaphambili ngokuchasene nokwahluka kweCorona

I-China ibonelela ngokukhuseleka kwangaphambili ngokuchasene nokwahluka kweCorona

Abaphandi baseTshayina baphuhlise isitofu sokugonya esingumgubo esilawulwa njengedosi enye ngokuphefumlela ngqo emiphungeni ukuvelisa impendulo esebenzayo yamajoni omzimba. Isitofu sokugonya sinokubonisa ii-antigens ezininzi, okuthetha ukuba idosi enye inokubonelela ngokhuseleko olubanzi kwiintsholongwane ezininzi zokuphefumla, ngokutsho kwapapashwa yiwebhusayithi ye-Atlas eNtsha, icaphula ijenali yeNdalo.

Impembelelo encinci yosulelo lwentsholongwane

Ukufika kobhubhani we-COVID-19 kukhokelele kwinkqubela phambili yetekhnoloji yogonyo, kubandakanya nogonyo lwe-mRNA olwaziwayo ngoku, uninzi lwazo lunikezelwa ngesitofu engalweni okanye kwisihlunu, luvelisa ukunganyangeki okuhlekisayo, o.k.e. kubandakanya ulwelo lomzimba kunye nokuxhomekeka kwii-antibodies nciphisa intsholongwane kodwa hayi ukhuselo lomzimba. Ngelixa izitofu ezitofwayo ze-SARS-CoV-2 zibonakaliswe ukunciphisa kakhulu ukugula kunye namazinga okusweleka, zinempembelelo encinci kumazinga osulelo lwentsholongwane.

Ulawulo kwangethuba losulelo

Ukuvelisa impendulo yokuzivikela kwi-mucosal tissues ye-airway ibalulekile ekulawuleni kwangethuba usulelo kwaye inokuvelisa i-immunity eqinile kunye nexesha elide kunye neempendulo zokukhumbula ngokukhawuleza. Ukujongana neengxaki ezinxulumene nezitofu zokugonya ezitofwayo, abaphandi abavela kwiZiko lobuNjineli beNkqubo ye-Academy yaseTshayina yeSayensi baye baphuhlisa idosi enye yokugonya eyomileyo yomgubo wokugonya.

I-Microspheres kunye ne-nanoparticles

Iqonga lokugonya elihlaziyiweyo lidibanisa i-microspheres ephilayo kunye neprotheyini ye-nanoparticles, indawo enokuthi ibonise i-antigens ezininzi, izinto ezibangela ukuba i-immune system ivelise ama-antibodies. Ubukho be-antigen engaphezulu kwesinye bandisa uluhlu lokhuseleko lwentsholongwane olubonelelwa sisitofu sokugonya kwaye lubangela impendulo ebanzi yamajoni omzimba. Umzekelo, inokubandakanya ii-antigens ezivela kwiintlobo ezahlukeneyo ze-SARS-CoV-2 okanye i-SARS-CoV-2 ngokudityaniswa nolunye ugonyo lwentsholongwane yokuphefumla.

I-Humoral kunye ne-immunity yeselula

Emva kokuba i-antigen nanoparticles ikhululiwe, imiphunga inokuyithatha ngokufanelekileyo. Ngenxa yokuba i-nanoparticles ikhutshwe ngokuzinzileyo, inika i-humoral ehlala ixesha elide, i-cellular kunye ne-mucosal immunity kunye ne-dose enye edibeneyo. Abaphandi bavavanya isitofu sokugonya sabo somgubo kwiimpuku, kwizilwanyana zaselabhoratri, nakwizifundo ezingezozabantu, kwaye babona imveliso eyomeleleyo ye-antibody kunye nempendulo ye-T-cell yendawo, ebonisa ukhuseleko lwentsholongwane olusebenzayo.

Uguqulo lwezonyango luyeza kungekudala

"Amacandelo ale nanosystem encinci asebenzisa iiproteni zendalo kunye nezixhobo ezivunyiweyo zepolymeric, kwaye ukusebenza kunye nokhuseleko lwesitofu sokugonya kuye kwafundwa ngokucwangcisiweyo kwiiprimates ezingezozabantu, ebonisa amandla amakhulu okuguqulelwa kweklinikhi," utshilo u-Wei Wei, omnye wabaphandi. kwisifundo.

Ukusuka kumbono wokuvelisa, into yokuba isitofu sokugonya singumgubo owomileyo sithetha ukuba ayifuni ifriji, enciphisa kakhulu iindleko zokugcina kunye nokuthutha kwaye yenza ukuba ifaneleke ukusetyenziswa kwiindawo ezingenayo okanye ezinqabileyo zefriji.

Uqikelelo lothando lweScorpio lonyaka ka-2024