Ukuxhatshazwa kwamajoni omzimba

Ukuphefumula okufutshane kwenzeka kwizigulane ezine-asthma ngenxa ye-bronchitis. Ngokusisiseko, sisistim somzimba esisebenza ngokugqithisileyo ekuphenduleni kwizinto ezinjengothuli, umsi, ungcoliseko okanye ezinye izinto ezivuselelayo.

Kuyaphawuleka ukuba uphando lwangaphambili lugxininise kwiprotheni ebizwa ngokuba yi-JAK1, edlala indima ephambili ekuvuseleleni iimpendulo ze-immune ngokuthumela izibonakaliso kwiiseli zokuzivikela ezibizwa ngokuba yi-phagocytes eziphelisa imizimba yangaphandle.

Kodwa ngaphandle kokubaluleka kwayo, i-JAK1 ngamanye amaxesha inokugqithiswa kwaye igqithise i-macrophages, ibangele ukudumba, okunokubonwa kuluhlu lweemeko, ezifana nesifo sika-Crohn, isifo samathambo kunye ne-asthma. I-Janus kinase inhibitors, okanye i-JAK emfutshane, iye yavela njengonyango olunokubakho kwezi meko.

imolekyuli "itaconate"

Kuphononongo olutsha, abaphandi beYunivesithi yaseZiqu-zintathu bachonge i-inhibitor ye-JAK, eyenziwa ngumzimba womntu. Imolekyuli, eyaziwa ngokuba yi-itaconate, yafunyanwa isebenza njengohlobo lokucima ukudumba ngokubeka iziqhoboshi kwiimacrophages ezisebenza ngokugqithisileyo.

Kukwavela ukuba isebenze kwi-JAK1, kwaye ezi patheni zidibeneyo zibonakala ngathi zicima ukudumba okunceda ukulwa ne-asthma.

amathemba aphezulu

Abaphandi baphinde bavavanya i-itaconate derivative ebizwa ngokuba yi-4-OI kwiimodeli zemouse ye-asthma enzima, engaphenduliyo kunyango oluqhelekileyo lwe-anti-inflammatory steroid. I-molecule yafunyanwa ukunciphisa ukusebenza kwe-JAK1 inhibitor kunye nokunciphisa ubunzima be-asthma kwiigundane.

UGqr Marh Runch, umphandi okhokelayo wophononongo, uthe: "Kukho ithemba elikhulu lokuba amachiza amatsha ase-itaconate anokuba namandla njengendlela entsha yonyango yokunyanga i-asthma enzima, apho kukho imfuneko engxamisekileyo yonyango olutsha."