ICorona entsha .. intsholongwane elawula ukulinganisa, ukungaqhelekanga kunye nemimangaliso

Ngelixa ilizwe liphela lisabandezeleka phantsi kwentsholongwane ye-corona esakhulayo, iingcali zizama ukubaleka ixesha lokusombulula imfihlakalo yotshaba loluntu, esele losulele abantu abangaphezu kwezigidi ezingama-44, kwaye labulala ngaphezulu kwesigidi, ukusukela oko yavela ngaphantsi konyaka ophelileyo okokuqala eTshayina.

Yintoni entsha namhlanje ifunyenwe kuphononongo oluqhutywe ngabaphandi kwiKholeji yeVagelos yeeGqirha kunye noGqirha kwiYunivesithi yaseColumbia, abathi iintsholongwane ze-corona zinobuchule ekulinganiseni iiproteni zomntu ezibandakanyeka kwisifo esibi se-Covid-19. Uphononongo lwapapashwa kwiwebhusayithi yejenali yeCell System.

Ubusika beCorona bumnyama kwaye kulindelwe okona kubi kakhulu ..

Ngokwenxalenye yakhe, uSagi Shapira, uprofesa oncedisayo we-biology ye-biology kwiKholeji yeVagelos yeeGqirha kunye noGqirha kwiYunivesithi yaseColumbia, kunye nomphandi okhokelayo wokufunda, wathi kwingxelo epapashwe ngoLwesibini kwiwebhusayithi yeyunivesithi: "Iintsholongwane zisebenzisa ukulinganisa ngenxa yezizathu ezifanayo izityalo. kunye nezilwanyana, ezibubuqhetseba," esongezelela: "Sasicinga ukuba ukuchongwa okufana neProtein yintsholongwane Iya kusinika umkhondo wendlela iintsholongwane - kubandakanya inoveli coronavirus - ezibangela ngayo. ”

“Ngaphezulu kunokuba besicinga”

Esebenzisa iikhompyutha ezinkulu ukukhangela imilinganiso yentsholongwane esebenzisa isoftwe efana ne-7000D yokubonwa kobuso, uShapira kunye neqela lakhe lophando bahlola iintsholongwane ezingaphezulu kwama-4000 kunye neenginginya ezingaphezu kwama-6 kwi-ecosystems yoMhlaba kwaye bafumanisa iimeko ezizizigidi ezi-XNUMX zokulinganisa iintsholongwane.

Umntwana uveza unyango lweCorona, ingaba intlekele iza kuphela?

Kwakhona wachaza ukuba “ukulinganisa kulicebo elixhaphake kakhulu phakathi kweentsholongwane kunokuba besicinga.” Isetyenziswa zizo zonke iintlobo zeentsholongwane, kungakhathaliseki ukuba zingakanani na iintsholongwane, ukuba intsholongwane ivelisa njani na, okanye intsholongwane yosulela iibhaktheriya, izityalo, okanye intsholongwane ebangela ukuba intsholongwane ibangele iintsholongwane, izityalo, intsholongwane, intsholongwane, intsholongwane, intsholongwane, intsholongwane, intsholongwane, okanye intsholongwane. izinambuzane okanye abantu.”

“Ingakumbi ikrelekrele”

Uqhubeke wathi, “Nangona kunjalo, ezinye iintlobo zeentsholongwane zisebenzisa ukulinganisa ngakumbi kunezinye. Ngelixa i-papillomaviruses kunye ne-retroviruses zingayisebenzisi kakhulu, sifumanise ukuba ii-coronavirus zinobuchule obukhethekileyo, kwaye sifumanise ukuba zilinganisa iiproteni ezingaphezulu kwe-150, kubandakanywa uninzi olulawula ukujiya kwegazi, iqela leeproteni zokhuselo lomzimba ezinceda ukujolisa kwii-pathogens. Izifo ezitshabalalisayo,” echaza ukuba: “Sasicinga ukuba ngokulinganisa amandla omzimba okuzikhusela kunye neeproteni ezijiyisayo, iikoronavirus zinokuzityhala ezi nkqubo ukuba zisebenze ngokugqithiseleyo zize zibangele izifo esizibona kubaguli abosulelekileyo.”

Kuyaphawuleka ukuba ngexesha lo bhubhani, kuye kwacaca ukuba uninzi lwabaguli abane-Covid-19 banengxaki ye-coagulation kwaye abanye babo ngoku banyangwa nge-anticoagulants kunye neziyobisi ezithintela ukusebenza kwezongezo.

Kwiphepha elahlukileyo elipapashwe kwiNature Medicine, abaphandi beYunivesithi yaseColumbia bafumene ubungqina bokuba ukusebenza kunye nokungasebenzi kakuhle kwemfuza kwenkqubo yokuncedisana kunye neeproteni zokujiyisa zinxulunyaniswa nesifo esibi se-COVID-19. Inkqubo yokuncedisana, eyona nxalenye ye-immune system eyenza amandla e-antibodies kunye ne-phagocytes ukususa ii-microbes kunye neeseli ezonakalisiweyo kwizinto eziphilayo. Baye bafumanisa ukuba abantu abane-macular degeneration (enxulunyaniswa nokusebenza kwenkqubo yokuncedisana) kunokwenzeka ukuba basweleke ngenxa ye-COVID-19, ukuba ukuncediswa kunye nofuzo oluhlwithayo lusebenza ngakumbi kwizigulana ezinesi sifo, kunye nokuba abantu abanotshintsho oluthile kunye noguqulo lwamahlwili babesebenza. kungenzeka ukuba ube nazo ezi.Imfuza esibhedlele ngenxa yesi sifo ngokunjalo.

Ukongeza, uShapira wajonga ukuba ukuphanda imisebenzi yeprotein yentsholongwane kunye nokulinganisa kubonisa ukuba ukufunda ngebhayoloji esisiseko yentsholongwane kunokuba yindlela enye yokufumana ukuqonda malunga nokuba iintsholongwane zisibangela njani isifo kwaye ngubani onokuba semngciphekweni omkhulu.

Kuxelwe ukuba ukusukela oko eli phepha lavela okokuqala ngentwasahlobo yalo nyaka kuguqulelo lokuqala, abanye abaphandi bafumene amakhonkco phakathi kobunzima bokongeza kunye ne-Covid-19, kwaye uninzi lwezilingo zeklinikhi ze-inhibitors zale nkqubo sele ziqalisiwe.