Uphononongo olutsha oluthembisayo lwezigulane ezinokusilela kwentliziyo

Uphononongo olutsha oluthembisayo lwezigulane ezinokusilela kwentliziyo

Ukungaphumeleli kwentliziyo yingxaki yezempilo yehlabathi edla ngokudityaniswa kukungaphefumli xa ulele, ukugula okuhambisanayo okwenza bufutshane ubomi bomntu.

Kwiindaba ezilungileyo, nangona kunjalo, iyeza elitsha elithembisayo liye laphuhliswa zizazinzulu ezivela kwiYunivesithi yaseAuckland eNew Zealand ezinokunyanga ukungaphumeleli kwentliziyo kunye ne-apnea yokulala ngokujolisa kumsebenzi we-neural oqhuba zombini, ngokutsho kweNdalo yoNxibelelwano.

Kubantu abanesifo sentliziyo i-prognosis imbi kwaye izinga lokufa liphezulu nangona intuthuko yakutshanje yonyango.

Ngokutsho kwe-US National Institutes of Health (NIH), ukungaphumeleli kwentliziyo kuchaphazela abantu abangaphezu kwezigidi ze-64 emhlabeni jikelele, okwenza kube yinto ephambili kwimpilo yoluntu jikelele.

Ngaphezu kwe-64 yezigidi zezigulane

Kubantu abanesifo sentliziyo, i-prognosis imbi kwaye izinga lokufa liphezulu nangona intuthuko yakutshanje kunyango.

Ngokutsho kwe-US National Institutes of Health (NIH), ukungaphumeleli kwentliziyo kuchaphazela abantu abangaphezu kwezigidi ze-64 emhlabeni jikelele, okwenza kube yinto ephambili kwimpilo yoluntu jikelele.

ukufa kwangoko

Ukungaphumeleli kwentliziyo kwenzeka xa imisipha yentliziyo iyancipha kwaye ayimpompa ngokufanelekileyo. Ingqondo iphendula ukusilela kwentliziyo ngokuvula inkqubo yemithambo-luvo enovelwano yomzimba, impendulo "yokulwa okanye yokubhabha", ukuvuselela intliziyo ukuba impompe ngokufanelekileyo.

Kodwa ukuvuselela ixesha elide, kudibaniswa ne-obstructive sleep apnea, kukhokelela ekunciphiseni ixesha lokuphila. Uninzi lwezigulana zifa phakathi kweminyaka emi-5 yokufunyaniswa ukuba zinesifo sentliziyo.

iikhemoreceptors

Kuyaziwa ukuba inxalenye yengqondo ethumela iimpembelelo entliziyweni ikwalawula ukuphefumla, kwaye i-apnea yokulala ephakathi (CSA) yenzeka xa ukuphefumla kuyeka ngokuphindaphindiweyo ngexesha lokulala ngenxa yokuba ingqondo ayithumeli imiqondiso efanelekileyo kwizihlunu zokuphefumla, imeko. eqhelekileyo phakathi kwabantu abanesifo sentliziyo.

Kukholelwa ukuba i-apnea yokulala ibangelwa ukwanda kovakalelo kwii-chemoreceptors ze-peripheral ezifumaneka kwi-carotid arteries, ebona ngokukodwa utshintsho kwi-arterial blood oxygenation, okanye i-hypoxia, kwaye iqalise ukusabela ukubuyisela amanqanaba e-oksijini kwisiqhelo. I-receptor enye, i-P2X3, ichaphazela le mpendulo ye-reflex.

AF-130 ichiza

Unyango lwangoku lwe-apnea yokulala luxinzelelo oluqhubekayo lwe-airway (CPAP), esebenzisa uxinzelelo oluthambileyo lomoya ukugcina iindlela zomoya zivulekile.

Nangona kunjalo, uxinzelelo oluqhubekayo lomoya womoya, olufuna ukunxiba imaski eqinileyo ngelixa ulele, aluzinzeki.

Unyango oluthembisayo kungekudala

Yintoni entsha kukuba iyeza elitsha elithembisayo liye laphuhliswa elijolise kumsebenzi we-neural obangela ukusilela kwentliziyo kunye nokulala.

Abaphandi abavela kwiYunivesithi yaseAuckland bavavanya ichiza, elaziwa ngokuba yi-AF-130, kwiimpuku ezinokusilela kwentliziyo okungapheliyo kunye ne-apnea yokulala. I-AF-130 ibonakaliswe ukuba ngumchasi onamandla we-P2X3, i-normalization ye-respiratory system yokuphendula kwi-hypoxia kunye nokuphucula kakhulu inani legazi elimpontshwa yintliziyo. Kwapheliswa izigulo zokuphefumla.

Ichiza elitsha licwangciselwe ukuvunywa kungekudala yi-US Food and Drug Administration (FDA), nangona kusetyenziso olwahlukileyo lwezonyango, okuthetha ukuba ulingo lwabantu lunokwenzeka kwiminyaka emibini ezayo.

Uqikelelo lukaMaguy Farah lwehoroscope yonyaka ka-2023