Uphononongo oluthembisayo kunyango lwesifo sikaParkinson

Uphononongo oluthembisayo kunyango lwesifo sikaParkinson

Bangaphezu kwezigidi ezili-10 abantu kwihlabathi liphela abaphila nePD okanye isifo sikaParkinson. Sisifo esinganyangekiyo se-neurodeergenerative esibonakaliswa kukungcangcazela, ukuqina kwezihlunu, ukungasebenzi kakuhle, kunye nokungalungelelani kakuhle kunye nolungelelwaniso.

Nangona kunjalo, uphando olutsha luye lwafumanisa ukuba uhlobo oluthile lwebhaktheriya yamathumbu lubangela "i-clumps" etshabalalisayo yeeseli ze-nerve, eziluphawu lwesifo sika-Parkinson.

Ngelixa oku kufunyanisiweyo kuvula umnyango kuphuhliso lonyango olujoliswe kwesi sifo sibuthathaka, ngokutsho kwengxelo yeNew Atlas kwiFrontiers kwijenali yeCellular and Infection Microbiology.

iprotheni ye-alpha-synuclein

Xa iprotein alpha-synuclein, efumaneka kakhulu kwiiseli zemithambo-luvo, iqokelelana, yenze imizimba yeLewy. Ubukho be-alpha-synuclein kunye nemizimba ye-Lewy ebuchosheni nakwinkqubo yonke ye-nervous luphawu lwesifo sikaParkinson.

I-Alpha aggregation syncytia nayo ifunyenwe emathunjini, kwaye kucingelwa ukuba i-pathogen esekwe emathunjini inokubangela ukudityaniswa, ethi emva koko ihambe iye kwingqondo.

edume ngakumbi

Ngelinge lokuqonda ngcono oonobangela besifo sikaParkinson, abaphandi abavela kwiYunivesithi yaseHelsinki eFinland baphonononga indima enokudlalwa luhlobo oluthile lwebhaktheriya, ngokukodwa iDesulfovibrio, edla ngokubizwa ngokuba yiDSV.

Kuyafaneleka ukuba uqaphele ukuba ikhonkco phakathi kwebhaktheriya ye-Desulfovibrio eyingozi kunye nesifo sika-Parkinson yaphandwa ngo-2021. Ngelo xesha, abaphandi bafumanisa ukuba ibhaktheriya yayixhaphake kakhulu kwizigulane ze-Parkinson. Bafumanise ukuba kukho ubukhali beempawu ezijongwayo kwizigulana ezinokwakheka okwandisiweyo kweebhaktheriya ze-DSV.

iintlobo ezithile

Nangona kunjalo, kuphononongo luka-2021, akuzange kuhlolwe ukuba iibhaktheriya ze-DSV zibe negalelo njani kuphuhliso lwesifo sikaParkinson. Ke, kwiCaenorhabditis elegans, abaphandi baye bajonga ukuba ngaba iintlobo ze-DSV zinegalelo ekuqokelelweni kwemizimba ye-alpha-synuclein kwaye ngenxa yoko kwisifo sikaParkinson.

Kwaye bagqiba, emva kovavanyo lwabo lwaselabhoratri, ukuba iintlobo zebhaktiriya ze-DSV ezivela kubantu abanesifo sikaParkinson, ngokungafaniyo nabantu abasempilweni, zibonakala zinetyhefu ngakumbi kwaye zinokubangela ukuqokelelana ngakumbi kwemizimba ye-alpha-synuclein, ebonisa ukuba iziphumo zophononongo zibalaselisa into ebalulekileyo. indima edlalwa yimiba yokusingqongileyo ekukhuleni kosulelo.Isifo sikaParkinson.

Iziphumo ezibalulekileyo

Ngokomxholo, uPer Saris, umbhali-mbhali wesifundo, wathi, "Iziphumo zethu zibalulekile, kuba imbangela yesifo sikaParkinson ayikaziwa nangona iinzame zokuyichonga kwiinkulungwane ezimbini ezidlulileyo."

Wongezelela wathi, "Iziphumo zibonisa ukuba iintlobo ezithile zeebhaktheriya ze-Desulfovibrio zinokubangela ukuba isifo sikaParkinson, oko kukuthi, sibangelwa kakhulu yimeko yendalo," echaza ukuba "ukuvezwa kwendalo kwiintsholongwane ze-DSV zebhaktheriya kubangela isifo sikaParkinson," ephawula ukuba "i-Parkinson's isifo siphumela Kuphela yipesenti encinci, okanye malunga ne-10%, yemfuza yomntu ngamnye.

Ukususa iintsholongwane eziyingozi

Kwakhona wachaza ukuba, ngenxa yeziphumo zophando, "abathwali bale bhaktheriya enobungozi banokufunyanwa kwi-Desulfovibrio. Ngaloo ndlela, banokujoliswa kwiinkqubo zokususa ezi ntsholongwane emathunjini, ezinokuthi zithobe kwaye zicothise iimpawu zesifo sikaParkinson.”

Kuboniswa ukuba uphando olongezelelweyo lwexesha elizayo lungabonisa ukungafani phakathi kweentlobo ze-Desulfovibrio DSV, eziye zabonwa kubantu abane-cerebral palsy kunye nezifundo eziphilileyo.

Uqikelelo lukaMaguy Farah lwehoroscope yonyaka ka-2023