Umhlaza wamabele ... unyango lufumaneka kwisiselo esilula

Kusoloko kukho ithemba, yaye kusoloko kukho into entsha kunyango lwezifo ezinganyangekiyo, kuquka umhlaza wamabele.” Uhlolisiso lwakutshanje lwaseMerika lwanikela ingxelo yokuba isondlo esisetyenziswa kwiziselo zezemidlalo sinokuwunyanga umhlaza wamabele onganyangekiyo ngamayeza.

Uphononongo luqhutywe ngabaphandi kwizibhedlele zaseMelika "iMayo Clinic", kwaye iziphumo zabo zapapashwa kwiphepha lesayensi ye-Cell Metabolism, ngokubhekiselele kwinto echazwe yi-arhente "Anatolia".

Abaphandi bachaza ukuba i-receptor ebizwa ngokuba yi-HER2, ihomoni enokuthi ikhuthaze ukukhula komhlaza, inoxanduva malunga ne-20-30% yamathumba omhlaza webele.

Bongeze ngelithi amayeza anyanga umhlaza wamabele afana ne “trastuzumab” aphucula ubomi kwezinye izigulana ezinomhlaza wamabele, kodwa amanye amathumba asenokunganyangeki kula machiza.

UDkt Taro Hitosuji, inkokeli yeqela lophando kunye noogxa banquma ukuhlola iindlela ezintsha zokusombulula le ngxaki, kwaye bavavanya ithuba lokusebenzisa isongezelelo sokutya esibizwa ngokuba yi "cyclocreatine" ekunciphiseni izicubu zomhlaza webele.

Abaphandi bafumanisa ukuba le ncediso, esetyenziselwa iziselo zezemidlalo, ithintele ukukhula kwe-hormone HER2 ejongene nomhlaza webele, ngaphandle kokubangela iziphumo ezinobungozi.

Esi siphumo size emva kophononongo olwenziwe kwiimpuku ezinomhlaza wamabele, ezibonise ukuxhathisa kumachiza omhlaza wamabele afana ne "trastuzumab".

Ulingo lwezonyango lwexesha elizayo ebantwini luya kuba yimfuneko ukumisela ukusebenza kweli chiza ekunyangeni umhlaza wamabele onganyangekiyo ngamachiza,” utshilo uMatthew Goetz, umlawuli weNkqubo yeMayo Clinic Breast Cancer.

Ngokutsho kwe-International Agency for Research on Cancer of the World Health Organization, umhlaza webele lolona hlobo luxhaphakileyo lwethumba phakathi kwabasetyhini kwihlabathi jikelele, kunye nommandla waseMbindi Mpuma ngokukodwa.

Eli qumrhu lathi nyaka ngamnye bamalunga ne-1.4 lesigidi abafunyaniswa benesifo, yaye esi sifo sibulala amabhinqa angaphezu kwama-450 ngonyaka ehlabathini lonke.