Unyango lwezigulane zombefu olunciphisa iziphumo zalo eziyingozi

Unyango lwezigulane zombefu olunciphisa iziphumo zalo eziyingozi

Ukusebenzisa unyango lwebhayoloji ukunciphisa ukudumba kwemiphunga kwenza ukuba i-92% yabantu abane-asthma enzima banciphise iidosi zabo zemihla ngemihla ze-steroids eziphefumlelweyo ngaphandle kokwandisa iimpawu zabo, uphononongo olutsha lufumene. Ezi ziphumo zithetha ukuba abantu abane-asthma enzima banokunciphisa umngcipheko wemiphumo emibi ehambelana nokusetyenziswa kwexesha elide le-steroid, ngokutsho kweNew Atlas, ecaphula iLancet.

Kubantu abamalunga nezigidi ezingama-300 abanesifo sombefu ehlabathini, malunga ne-3% ukuya kwi-5% banesifo sombefu esimandundu, abanengxaki yokuphefumla yonke imihla, ukuxinana kwesifuba kunye nokukhohlela okuhlala kukhokelela esibhedlele. Uninzi lwezigulana zombefu zinohlobo olusezantsi olubizwa ngokuba yi-eosinophilic asthma, oluphawulwa ngamanqanaba aphezulu eeseli zomzimba (eosinophils) egazini ezibangela ukudumba okungalawulekiyo kunye nokudumba kweendlela zomoya.

Yiphephe imiphumo emibi enokubakho

Unyango olucetyiswayo lwe-asthma ye-eosinophilic, ngokwe-Global Initiative ye-Asthma (GINA), yindibaniselwano yemihla ngemihla ye-budesonide (i-corticosteroid e-inhaled ukulawula ukuvuvukala) kunye ne-formoterol (i-bronchodilator yexesha elide yokuphumla nokuvula umoya). Olu nyango, olwaziwa njenge-ICS okanye "i-steroid," ikhethwa ngaphezu kwe-inhalers "yokuhlangula" esebenza ixesha elifutshane ngenxa yeziphumo zayo ezimbini ezichasayo kunye ne-bronchodilator. Kodwa ukusetyenziswa kwexesha elide kunokuba yingxaki, njengoko ihambelana ne-oral thrush, i-osteoporosis, isifo sikashukela, i-immune system, kunye ne-cataracts.

Uphononongo, olwenziwa zizazinzulu ezivela kwiKholeji yaseKing yaseLondon kwizigulana kumazwe amane: i-United Kingdom, iFrance, i-Italiya neJamani, yavavanya ukuba ngaba unyango lwe-benralizumab (unyango lwebhayoloji) luvumela abantu abanesifo sombefu esiqatha se-eosinophilic ukunciphisa umthamo we-ICS ngaphandle kokulahlekelwa. ukulawula iimpawu zabo.

UDavid Jackson, inkokeli yeqela lophando, uthe: "Unyango lwebhayoloji olufana ne-benralizumab lutshintshe kakhulu ukhathalelo lwesifuba esinzima ngeendlela ezininzi, kwaye iziphumo zophononongo olutsha zibonisa okokuqala ukuba ingozi enxulumene ne-steroid inokuthintelwa uninzi lwabantu. abaguli abasebenzisa olu nyango.”

I-Benralizumab inikwa ngesitofu esingaphantsi kwesikhumba kanye kwiiveki ezine kwiidosi ezintathu zokuqala, emva koko kube kanye kwiiveki ezisibhozo.

Iziphumo zophando zibonise ukuba, ngokubanzi, i-92% yabathathi-nxaxheba banciphisa umthamo we-ICS. Ngokukodwa, i-15% yabo yanciphisa umthamo kwi-dose ephakathi, i-17% ukuya kwi-dose ephantsi, kunye ne-61% kwidosi njengoko kufuneka kuphela. Kwakhona, i-91% yabathathi-nxaxheba abazange bafumane nakuphi na ukuphazamiseka kweempawu ngexesha lokucofa.

I-Sagittarius ithanda i-horoscope yonyaka we-2024