Unyango oluthembisayo lomhlaza wamabele

Unyango oluthembisayo lomhlaza wamabele

Iyeza elijolise kwiprotheyini ekhuthaza ukukhula komhlaza wamabele libonakaliswe lisebenza ngokuchasene namathumba anamanqanaba asezantsi kakhulu eprotheni okokuqala.

Olu ayilonyango, kodwa yenye yeenzuzo zamva nje kwimpendulo ekujoliswe kuyo kumhlaza, enokuthi ivule ucango lokuba nokwenzeka kokuvelisa unyango olutsha kumawakawaka ezigulana ezinomhlaza wamabele ophezulu.

Ukuza kuthi ga ngoku, umhlaza wamabele uchazwe njenge-HER2-positive, apho iiseli zomhlaza zineprotheyini eninzi kunesiqhelo, okanye i-HER2-negative.

Ukudibanisa ichemotherapy

Oogqirha ababhengeze impumelelo entsha ngeCawe bathi izakwenza udidi oluphantsi lwe-HER2 lube ludidi olutsha lokukhokela unyango lomhlaza wamabele.

Malunga nesiqingatha sezigulana ezinomhlaza webele wexesha elidlulileyo zihlelwa njenge-HER2 negative kwaye eneneni inokuba yi-HER2 ephantsi kwaye ifanelekele ichiza.

Ichiza yi "Enherto", indibaniselwano yechemotherapy kunye ne-antibodies etofwe kwi-vein, efumana kwaye ithintele iprotheni ye-HER2 kwiiseli zomhlaza, ngelixa ikhupha ikhemikhali enamandla yokubulala umhlaza kwezo seli.

Ichiza elitsha lelodidi olutsha lwamachiza abizwa ngokuba zii-antibody conjugates.

Ichiza sele livunyiwe ngenxa yomhlaza webele one-HER2, kwaye ngo-Epreli uLawulo lokuTya kunye neChiza lase-US linike ubume bokuphumelela kweli qela litsha lezigulane.

ichiza eliphambili

Kuphononongo olutsha, iyeza landisa ixesha labaguli abaphila ngaphandle komhlaza kunye nokuphucula ukusinda xa kuthelekiswa nezigulana ezifumana ichemotherapy rhoqo.

Uphononongo lukwathelekise i-Inherto kunye ne-chemotherapy eqhelekileyo kwizigulane eziphantse zibe ngama-500 ezinomhlaza webele we-HER2 ophantsi oye wasasazeka okanye onganyangwanga ngotyando.

Ichiza lamisa ukuqhubela phambili komhlaza malunga neenyanga ze-10, xa kuthelekiswa neenyanga ezi-5 kunye nesiqingatha kwiqela elifumana ukunakekelwa rhoqo.

Ichiza likwaphucule ukuphila malunga neenyanga ezintandathu (ukusuka kwiinyanga ezili-17.5 ukuya kwiinyanga ezingama-23.9).