Indlela yokumelana neemeko zokubanda kunye nokubanda?

Indlela yokumelana neemeko zokubanda kunye nokubanda?

Ngokufika kobusika, iintsholongwane ziqala ukusasazeka kwinkqubo yokuphefumula, ngelixa izinto ezikhuthaza ukusuleleka phakathi kwazo zivela, umzekelo, inani elikhulu leendibano ngaphakathi kweendawo ezivaliweyo apho iintsholongwane zihlala ngcono, ekubeni umoya wangaphakathi womile. Kodwa bekungaqinisekanga ukuba amaqondo obushushu aphantsi awenza buthathaka inkqubo yomzimba yokuzikhusela, kwaye ukuba kunjalo, kwenziwa njani oku.

Uphononongo olupapashwe ngoLwesibini kwiJenali ye-Allergy kunye ne-Clinical Immunology iphonononga indlela entsha umzimba ohlasela ngayo iintsholongwane kwaye isebenza ngcono xa kushushu.

UMansour Amiji, unjingalwazi kwiYunivesithi yaseMntla-mpuma, oye wabhalisa isifundo, uxelele i-AFP ukuba ezi zinto zifunyanisiweyo zinokunceda ukuphuhlisa unyango olutsha lwengqele kunye nezinye iintsholongwane.

Umsebenzi wophando uqhubekile kuphononongo lwangaphambili olwenziwa ngu-Amiji ngo-2018, oye wafumanisa ukuba iiseli zempumlo zikhupha ii-vesicles ze-extracellular, iqela leemolekyuli ezincinci ezihlasela iibhaktheriya xa umoya uphuma.

UAmiji ubonisa ukuba “owona mzekeliso ubalaseleyo wale nkqubo yindlwane yeempondo.” Njengoonomeva abakhusela indlwane yabo xa behlaselwa, iingxowa zibhabha ngaphandle kweseli ngokwamaqela, emva koko zincamathele kwiibhaktheriya kwaye zibabulale.

Abaphandi bazibuze imibuzo emibini: Ngaba ukukhuselwa kwee-vesicles ezingaphandle kwe-extracellular vesicles nazo zirekhodwa kubukho bentsholongwane? Yaye ukuba kunjalo, ngaba ukusabela kwayo kuchatshazelwa bubushushu?
Kwiimvavanyo zabo, izazinzulu zasebenzisa i-membrane ye-mucous yeempumlo zamavolontiya (ababenziwa utyando lokususa iipolyps) kunye nento apho usulelo lwentsholongwane luphindaphindeka.
Isiphumo yaba linani elilungileyo lee-extracellular vesicles ezikhuselwe ukuhlasela iintsholongwane.

"Inguqulelo yokuqala ekholisayo"

Ukuphendula umbuzo wesibini, i-mucous membranes yeempumlo yahlulwa yangamaqela amabini, aphantsi kophuhliso kwibhubhoratri, eyokuqala ngama-37 degrees Celsius, ngelixa elesibini ngama-32 degrees Celsius.

Amaqondo obushushu amabini akhethwe ngokusekelwe kwiimvavanyo ezibonisa ukuba iqondo lokushisa ngaphakathi kwempumlo lehla malunga ne-5 ° C xa ubushushu bomoya wangaphandle buyehla ukusuka kwi-23 ° C ukuya kwi-4 ° C.

Phantsi kweemeko zobushushu bomzimba obuqhelekileyo, i-extracellular vesicles ikwazile ukulwa neentsholongwane kakuhle, ngokuzinika "i-decoys" apho iintsholongwane zihlala khona, endaweni ye-cell receptors abadla ngokujolisa kuyo.

Kodwa ngamaqondo obushushu asezantsi, iivesicle ezimbalwa zakhutshelwa ngaphandle kweseli kwaye zazingasebenzanga kangako ngokuchasene neentsholongwane abazivavanyayo, eziziintlobo ezimbini zerhinoviruses kunye ne-coronavirus (engeyo-Covid), eqhelekileyo ngexesha lasebusika.

UBenjamin Blair, umbhali kunye nolo phando kunye nogqirha wotyando kwiSikolo sezoNyango saseHarvard, uthi, “Akukho sizathu sibambekayo esiye sabhalwa ukuchaza ukwanda okucacileyo kosulelo lwentsholongwane ebudeni beenyanga ezibandayo,” echaza ukuba iziphumo zolu hlolisiso zibonisa ingcaciso yokuqala eqinisekisayo yobungakanani nebhayoloji ekufikelelwa kuyo.” .

UMansour Ameji uqaphela ukuba iziphumo zophononongo zinokukhokelela kuphuhliso lonyango ukukhuthaza imveliso yendalo ye-extracellular vesicles, ngenjongo yokulwa ngcono ingqele kunye nomkhuhlane kunye ne-Covid-19, esongeza, “Le ndawo yophando. kakhulu, kwaye ngokuqinisekileyo siza kuqhubeka nokusebenza kuyo. ”