Luluphi unxibelelwano phakathi kwezifo zenkqubo yokwetyisa kunye nengqondo?

Luluphi unxibelelwano phakathi kwezifo zenkqubo yokwetyisa kunye nengqondo?

Izifundo zezilwanyana zakutsha ziye zabonisa ukuba isifo se-Alzheimer sinokudluliselwa kwiigundane ezincinci ngokugqithiselwa kwe-microbes yamathumbu, eqinisekisa ukudibanisa phakathi kwenkqubo yokugaya kunye nempilo yengqondo, ngokwento epapashwe yi-website ye-Science Alert website, echaza iphephancwadi Iingxelo zeNzululwazi.

Isiphumo esibi sokuvuvukala

Uphononongo olutsha longeza inkxaso eyongezelelekileyo kwithiyori yokuba ukudumba kusenokuba yeyona ndlela yokuba nefuthe elibi kwimpilo yengqondo.” “Kufunyaniswe ukuba abantu abanesifo sika-Alzheimer banokudumba kwamathumbu,” utshilo isazi ngengqondo uBarbara Bendlin weYunivesithi Wisconsin: “Umfanekiso wobuchopho, abo banokudumba okuphakamileyo emathunjini babenamanqanaba aphezulu e-amyloid [protein clumps] ebuchotsheni babo.”

Uvavanyo lweCalprotectin

UMargo Heston, ugqirha wezifo kwiYunivesithi yaseWisconsin, kunye neqela lamazwe ngamazwe labaphandi bavavanya i-fecal calprotectin, uphawu lokuvuvukala, kwiisampuli ze-stool ukusuka kwi-125 yabantu abakhethiweyo kwizifundo ezimbini zokuthintela isifo se-Alzheimer. Abathathi-nxaxheba baye bafumana iimvavanyo ezininzi zengqondo ekubhaliseni isifundo, ngaphezu kodliwano-ndlebe lwembali yentsapho kunye neemvavanyo zomngcipheko ophezulu we-Alzheimer's gene. I-subset iye yavavanywa kwiikliniki zeempawu ze-amyloid protein clumps, isalathisi esiqhelekileyo sesifo esijongene nemeko ye-neurodeergenerative. Ngelixa amanqanaba e-calprotectin ayephezulu ngokubanzi kwizigulane ezikhulileyo, aye avakaliswa ngakumbi kwabo baneempawu ze-amyloid zesifo se-Alzheimer.

I-Alzheimer okanye inkumbulo ebuthathaka

Amanqanaba ezinye i-biomarkers zesifo i-Alzheimer's nazo zanda ngamanqanaba okudumba, kwaye amanqaku ovavanyo lwenkumbulo ancipha njengoko i-calprotectin iphakama ngokunjalo. Nabathathi-nxaxheba abangafunyaniswanga ukuba banesifo se-Alzheimer babenamanqaku ememori ahlwempuzekileyo kunye namazinga aphezulu e-calprotectin.

Utshintsho kwiibhaktheriya zamathumbu

Uhlalutyo lwelabhoratri luye lwabonisa ngaphambili ukuba iikhemikhali ezivela kwiibhaktheriya zamathumbu zinokuvuselela imiqondiso yokuvuvukala kwingqondo. Olunye uphando luye lwafumanisa ukwanda kwamathumbu emathumbu kwizigulane ze-Alzheimer xa kuthelekiswa neqela lokulawula.
U-Heston kunye noogxa bakhe bacebisa ukuba utshintsho kwi-microbiome lukhokelela kwiinguqu emathunjini ezikhokelela ekudumbeni kwinqanaba lenkqubo. Oku kudumba kuncinci kodwa kungapheliyo, kwaye kubangela umonakalo ofihlakeleyo kunye noqhubekayo ophazamisana novakalelo lwezithintelo zomzimba.

Umqobo wegazi-ubuchopho

"Ukonyuka kwamathumbu emathunjini kunokukhokelela kumazinga aphezulu eemolekyuli ezivuthayo kunye neetyhefu ezivela kwi-lumen yamathumbu egazini, okukhokelela ekuvukeleni kwenkqubo, okunokuthi kunciphise umqobo wegazi kunye nokukhuthaza ukuvuvukala," kusho uFederico Re, unjingalwazi. ye-bacteriology kwiYunivesithi yaseWisconsin State. imithambo-luvo, [ngaloo ndlela ibangela] ukwenzakala kwemithambo-luvo kunye nokonakala kwemithambo-luvo.”

Utshintsho lokutya

Abaphandi ngoku bazama iimpuku zaselabhoratri ukubona ukuba utshintsho ekutyeni okuhambelana nokunyuka kokudumba kunokubangela uhlobo lwesifo se-Alzheimer kwiimpuku.
Ngaphandle kwamashumi eminyaka yophando, alukabikho unyango olusebenzayo kwizigidi zabantu abanesifo sika-Alzheimer kwihlabathi liphela. Kodwa ngokuqonda ngakumbi iinkqubo zebhayoloji, izazinzulu ziya zisondela ngokusondela.

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