Unobangela obaluleke kakhulu wesifo sezintso

Unobangela obaluleke kakhulu wesifo sezintso

Iqela lezazinzulu kwiYunivesithi yasePennsylvania lichonge indima edlalwa yi-enzyme ebizwa ngokuba yi-nicotinamide adenine dinucleotide NAD+ kwisifo sezintso, ivula umnyango kwiindlela ezintsha zokuthintela kunye nokunyanga le meko ixhaphakileyo kwaye inokuba yingozi, ngokutsho kwewebhusayithi yeAtlas entsha. Kwiphephancwadi iNature Metabolism.

Ngokutsho kweWorld Health Organization (WHO), isifo sezintso siye sakhula sisuka kwindawo ye-2019 ebangela ukufa saya kutsho kowe-1.3. Ngo-XNUMX, abantu abazizigidi ezisisi-XNUMX babulawa sisifo sezintso. Kodwa kaninzi kuyenzeka ukucotha okanye ukunqanda isifo sezintso ukuba siqhubele phambili ukuya kukusilela kwezintso ukuba sibanjwe kwaye sinyangwe kwangoko.

ibhalansi ye-metabolic

I-NAD + coenzyme nicotinamide adenine dinucleotide, i-coenzyme, ifumaneka kuyo yonke iseli ephilayo apho ilawula iindlela ezahlukeneyo zemetabolism, kunye nokubandakanyeka kulungiso lwe-DNA kunye nokusebenza kweeseli zomzimba. Kuyimfuneko ukugcina ibhalansi yemetabolism ngempembelelo yayo kwi-mitochondria, eyijenereyitha yamandla kwiseli, kwaye ngaphandle kwamanqanaba aneleyo e-enzyme, iiseli zomzimba azivelisi amandla ayimfuneko ukwenza imisebenzi yazo ye-metabolic.

Iiseli ze-tubule ezintso zifuna amandla amaninzi aveliswa yi-mitochondria ukuze zenze umsebenzi wazo, ziphinde zifake izondlo ezibalulekileyo kunye nokukhupha inkunkuma kunye ne-toxins. Xa i-mitochondria kwezi seli zonakalisiwe, impendulo yokuvuvukala ibangelwa ukuba ingakhokelela kwisifo sezintso, ekhokelela ekudibaneni kwamanzi, i-electrolytes kunye neemveliso zenkunkuma emzimbeni.

iisampulu zabantu okokuqala

Kuphononongo olutsha, abaphandi basebenzise i-metabolomics, isifundo seemolekyuli ezincinci ezifumaneka kwigazi kunye nomchamo, ukwenza imephu yeenguqu zemetabolism kwizintso zabantu. Inika umlinganiselo we-metabolites, iimolekyuli ezincinci kakhulu eziveliswa ngexesha le-metabolism; Ukuqonda imeko yempilo yomntu. Esi sisihlandlo sokuqala ukuba iisampulu zabantu zisetyenziswe kwizifundo ze-metabolic.

Inkqubo yesifo esisiseko

Abaphandi bavavanya iisampulu zezintso kwiqela lolawulo olusempilweni ngokuchasene neesampulu ezivela kwizigulane ezinesifo seswekile okanye isifo sezintso esibangelwa luxinzelelo lwegazi oluphezulu. Kuye kwavela ukuba amanqanaba e-NAD + kwizintso ezigulayo ayephantsi kakhulu. Ukuvavanya indlela yesifo ephantsi kwalo mahluko, baye benza i-RNA-ulandelelwano lweesampulu.

Thintela ukonakala kwezintso

Abaphandi bafuna ukufumana ubudlelwane phakathi kwamanqanaba e-NAD + kunye ne-mitochondrial gene expression, kwaye bagqiba kwelokuba amanqanaba asezantsi e-NAD + yayiyeyona nto iphambili yesifo sezintso zabantu. Kwakhona, xa iimpuku zaselebhu zanikwa ukongezwa kwe-NAD+ ngaphambili, i-nicotinamide riboside okanye i-nicotinamide mononucleotide (NMN), ukunyusa amanqanaba e-NAD+, i-tubular cell mitochondria yayikhuselwe emonakalweni, ngaloo ndlela ithintela ukukhula kwesifo sezintso.

Ukuphuhlisa iindlela zonyango

Umphandi ohamba phambili wophando, uKatalin Sostak, ubonise ithemba lokuba "olu phando luya kukhokelela ekuphuculeni ukunakekelwa kwixesha elizayo, ngoko xa izigulane zineenguqu ze-metabolite, zinokufumana unyango ngaphambi kokuba ukuphazamiseka kwezintso kubonakale."

Abaphandi banethemba lokuba isifundo sabo siya kukhokelela kwizifundo eziqhubekayo malunga nendima ye-metabolites kwisifo sezintso kunye nokuphuhliswa kweendlela ezintsha zokuthintela kunye nonyango.

"Ukuchongwa kwe-NAD + -i-sensitive downstream systems ibalulekile ekuqondeni iimeko ezinokuthi zizuze kwi-NAD + supplementation," kusho uJoseph Bauer, umbhali-mbhali wesifundo.

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