Will science save us from the nightmare of old age?

Will science save us from the nightmare of old age?

The years pass and the signs of aging begin to appear on us. There is no escaping age. Since 2015, we have witnessed a qualitative and unprecedented scientific leap with regard to tablets that combat aging and slow down its pace.

In the new, according to what was published in the Journal of Scientific Reports, citing a study conducted by the University of Leicester, England, scientists were able to improve the effectiveness and safety of “aging analyzer” drugs to treat antibodies with precision that allows them to target dysfunctional cells without harming healthy cells.

The great potential of anti-aging treatment also lies in its ability to target what are known as senescent cells, that is, those that have lost their ability to divide and accumulate in the body and accelerate the aging process.

While the accumulation of senescent cells is a normal part of the aging process, scientists have made some exciting steps on how to remove these cells from the body using purpose-made medications.

"Healthy Period"

Geriatric drugs have been shown to regenerate old cells in rodents and extend their lifespan, while promising progress has also been made in using them to improve what is known as a healthy lifespan.

And last month saw a surprising model presentation, in which scientists demonstrated how “geriatric” drugs can remove aging cells in the spines of (experimented) animals at advanced ages and create space for new, healthy cells to thrive, increasing the possibility of a new treatment for back pain. chronic in humans.

random shooting

The international team of scientists behind this latest study also targeted what they see as a flaw in the current generation of “aging analyzer” drugs, as they say they take the approach of shooting random bullets from guns that need more accuracy and selectivity, according to their description.

Salvador McCabe, the principal investigator of the University of Leicester study, said: “Gerolysis drugs are a new class of drugs with great potential for relieving the symptoms of aging. But there are strong side effects so far, and thus highlight the importance of the second generation of anti-aging drugs, which target aging cells without affecting other cells.”

This unprecedented development builds on previous research by a team of University of Leicester scientists, which identified a membrane marker for senescent cells and showed how they can be targeted to eliminate them with a high level of precision, making it possible to develop a new compound of an antibody loaded with cytotoxic drugs. , and put it to the test on cell cultures in the laboratory.

promising results

In addition, selective proof-of-concept experiments have returned some promising results, whereby the combined effect of antibodies and drugs is like a “smart bomb”, aging cells are identified and eliminated by toxic drugs to take them out of the equation.

The scientists confirmed that the treatment had no effect on non-senescent cells, which had a good impact on the accuracy and safety of the treatment.

An idea approach to cancer treatment

"By copying an idea already used in cancer treatments, an antibody has been modified so that it can specifically recognize these cells and deliver a toxic charge inside them," McCabe added.

The scientists said that this method is completely new to get rid of aging cells, pointing out that they hope to repeat this success with humans one day, stressing that they will use these results as a basis for further study in more targeted treatments for aging.

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