interferon molecules

The immune system response involves the secretion of interferon-stimulating genes, which are immune system molecules that are involved early in fighting disease by preventing viral replication.

Yale University researchers had previously concluded that such an immune response from a cold could protect against influenza, and in this sense, the new hypothesis related to protection against Covid was put forward.

lab cultured tissue

The researchers used airway tissue from a human body grown in a laboratory, where the artificial tissue was infected with the virus that causes colds and then the Corona virus. It was found that after exposure to a cold virus, airway tissues activate immune system cells and completely stop the spread of the Corona virus.

Thus, the immune system's response can be adapted to respond to such treatments in patients with COVID-19, provided the patient receives treatment in a timely manner.

Virus multiplication rate

It has also been observed that the virus seeks to replicate significantly at the beginning of COVID-19 before the immune system develops a strong defensive response, said Dr. Elaine Foxman, professor of medicine at Yale University and lead researcher on the study. Thus, the immune response to the cold virus is more effective against SARS-CoV-2 in its early stages, and therefore any treatment based on this immune response will have to be given to the patient immediately after infection. This can be challenging because Covid patients are not easily diagnosed early, with symptoms not beginning to appear until a few days after infection.

And in later stages of COVID-19, high levels of interferon, the molecules that are supposed to play a role in the immune system's early response, can over-stimulate the immune system, leading to a more severe disease state.

right time

Dr. Foxman added that it will all "depend on timing", and even if anti-Covid therapies are not developed, based on the concept of immune response from the common cold, the study still provides new insight into the complex ways in which viruses interact with each other - It is an important area for future study regarding disease outbreaks, noting that “there are hidden interactions between viruses that we do not fully understand, but the results of (the study) are part of the solution to the current puzzle.”

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