Sabon bincike akan kara yawan haihuwan mata

Sabon bincike akan kara yawan haihuwan mata

Haihuwar mace na kan raguwa tun daga tsakiyar shekarunta 30, wanda zai iya sa ya fi wahala samun yara a tsakiyar shekaru. A baya-bayan nan ne wata tawagar masana kimiyya suka gano wata hanyar da ke nuna saurin tsufan kwayan kwai, kuma sun gano wata hanya, akalla a cikin beraye ya zuwa yanzu, don rage ta domin kara samun haihuwa a gaba a rayuwa, a cewar New Atlas, yana mai cewa. mujallar Nature Aging.

Lalacewar noman wucin gadi

Babu gabobi da suka tsufa daidai gwargwado, kuma abin takaicin ovaries na ɗaya daga cikin gabobin da ke fama da wannan al'amari cikin sauri, amma masana kimiyya ba su da cikakken tabbacin dalilin da ya sa. Tun daga kusan shekaru 35, ovaries suna tsufa da sauri, yana haifar da raguwar ingancin kwai da nasara a ciki. Yawancin marasa lafiya suna amfani da ƙwayar cuta ta wucin gadi, amma hanya ce da ke da tsada kuma tana kawo sabbin haɗari.

CD38

A cikin sabon binciken, masana kimiyya na jami'ar Zhengzhou da ke kasar Sin sun binciki hanyoyin nazarin halittu da ka iya haifar da wannan koma baya. Sun yi nazarin tsarin bayyanar da kwayoyin halitta a cikin kananan beraye, kimanin watanni biyu, da kuma mice masu matsakaicin shekaru, kimanin watanni takwas, a cikin ovaries da sauran gabobin.

Masu binciken sun gano cewa a cikin tsofaffin beraye, bayyanar da kwayar halitta mai suna CD38 ya karu, musamman a cikin ovaries. Wannan ba abin mamaki ba ne gabaɗaya, domin CD38 sanannen masanin ilimin halitta ne na tsufa, saboda yana samar da wani enzyme wanda ke rushe furotin mai suna NAD +, wanda daga baya aka samu a ƙananan matakan a cikin tsofaffin beraye.

Ingancin sel da qwai

Sunan furotin na NAD, da nau'in oxidized NAD +, yana daidaita metabolism na sel da gyaran DNA, kuma a zahiri yana raguwa tare da shekaru. An danganta matakan da suka fi girma tare da tsawon rayuwa da ingantacciyar lafiya kamar yadda suke da shekaru, don haka ya zama abin da aka fi mayar da hankali ga binciken rigakafin tsufa na zamani, tare da wasu sakamako masu ban sha'awa. Yanzu ya bayyana cewa wannan al'amari na kowa kuma shine sanadin raguwar shekarun haihuwa a cikin haihuwa.

"Wannan raguwar [NAD +] tana wakiltar jerin abubuwan da ba su da kyau, musamman ma suna shafar ingancin ƙwayoyin somatic da ƙwai, don haka suna yin tasiri mai zurfi a kan haihuwa na mata," in ji Qingling Yang, mai bincike kan sabon binciken.

Bincike akan mice

A cikin gwaje-gwajen da suka biyo baya, ƙungiyar ta goge kwayar halittar CD38 a cikin tsofaffin beraye - kuma tabbas ya isa, sakamakon ya fi, ƙwai masu inganci. Daga nan ne masu binciken suka fara gwaje-gwajen don ganin ko za a iya samun irin wannan tasiri ba tare da injiniyoyin kwayoyin halitta ba, domin ya zama mafi dacewa da maganin haihuwa.

gwaji na asibiti

Bugu da kari, masu binciken sun juya zuwa wani kwayar halitta mai suna 78c, wanda ke hana CD38, kuma an ba shi ga berayen dakin gwaje-gwaje na watanni takwas a zahiri. Tabbas, matakan NAD + sun karu a cikin ovaries, kuma berayen sun sami damar haihuwa.

A halin yanzu ana gudanar da gwaje-gwaje na asibiti don ganin ko haɓaka matakan NAD + a cikin matan da ke fuskantar taimakon jiyya na haihuwa na iya inganta ƙimar nasara da rage haɗarin lahani na haihuwa.

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