Immune hyperactivity

Rashin numfashi yana faruwa a marasa lafiya masu ciwon asma saboda mashako. Mahimmanci, tsarin garkuwar jiki ne da ya wuce kima don mayar da martani ga allergens kamar ƙura, hayaki, gurɓatawa ko wasu abubuwan motsa jiki.

Abin lura shi ne cewa binciken da aka yi a baya ya mayar da hankali ne kan wani sunadaran da ake kira JAK1, wanda ke taka muhimmiyar rawa wajen karfafa garkuwar jiki ta hanyar aika sakonni zuwa kwayoyin halittar da ake kira phagocytes wadanda ke kawar da jikin waje.

Amma duk da mahimmancinsa, JAK1 na iya zama wani lokaci ya wuce gona da iri da macrophages, yana haifar da kumburi, wanda ana iya gani a cikin yanayi daban-daban, kamar cutar Crohn, rheumatoid arthritis da asma. Janus kinase inhibitors, ko JAK a takaice, sun fito a matsayin yuwuwar jiyya ga waɗannan yanayin.

kwayoyin "itaconate"

A cikin sabon binciken, masu bincike na Jami'ar Trinity sun gano wani mai hana JAK, wanda jikin mutum ya samar. Molecule, wanda aka fi sani da itaconate, an gano yana aiki azaman nau'in kashe kumburi ta hanyar sanya birki akan macrophages mai wuce gona da iri.

Hakanan ya zama yana aiki akan JAK1, kuma waɗannan samfuran haɗin gwiwar suna kama da kashe kumburi wanda ke taimakawa yaƙi da asma.

babban bege

Har ila yau, masu binciken sun gwada wani nau'in itaconate mai suna 4-OI a cikin nau'in linzamin kwamfuta na asma mai tsanani, wanda ba ya amsa ga daidaitattun magungunan steroid na anti-inflammatory. An samo kwayoyin don rage kunna mai hanawa JAK1 da rage tsananin asma a cikin mice.

Dokta Marh Runch, jagoran binciken, ya ce: "Akwai kyakkyawan fata cewa sabbin magungunan itaconate na iya samun damar zama sabuwar hanyar warkewa gaba ɗaya don magance cutar asma, inda ake buƙatar sabbin hanyoyin kwantar da hankali."