Neuropathy na gefe ba cuta ɗaya ba ne, a gaskiya shi ne lalacewar jijiyoyi ta hanyar yanayi da dama. Abubuwan da ke haifar da neuropathy sun haɗa da:

1- Ciwon suga (diabetic neuropathy).

2- Radical peripheral neuropathy saboda matsalolin kashin baya da kashin baya.

3- Ragewa ko matsa lamba akan jijiyoyi: Rauni, kamar haɗarin mota, faɗuwa ko raunin wasanni, na iya yanke ko lalata jijiyoyi na gefe. Ana iya haifar da shi ta hanyar matse jijiyoyi ta hanyar simintin gyare-gyare, amfani da sanduna, ko maimaita motsi kamar rubutu.

4-Rashin Vitamin: Bitamin B (ciki har da B-1, B-6, da B-12), bitamin D da niacin suna da mahimmanci ga amincin jijiya.

5- Hypothyroidism.

6-Magunguna: Wasu magunguna musamman wadanda ake amfani da su wajen magance cutar kansa (chemotherapy) na iya haifar da hakan.

7. Cututtukan autoimmune: Waɗannan sun haɗa da ciwo na Sjögren, lupus, rheumatoid arthritis, ciwo na Guillain-Barré, na kullum demyelinating polyneuritis da necrotizing vasculitis.

8- Yawan shan barasa.

9- Fitar da guba. Abubuwa masu guba sun haɗa da ƙarfe masu nauyi ko sinadarai.

10- Kamuwa da cuta: Wannan ya hada da wasu cututtukan da suka hada da kwayoyin cuta ko kwayoyin cuta da suka hada da cutar Lyme, herpes zoster (varicella zoster), Epstein-Barr virus, hepatitis C, leprosy, diphtheria da HIV.

11- Cututtukan gado. Cututtuka irin su cutar Charcot-Marie-Tooth nau'ikan neuropathy ne na gado.

12- Ciwon Tumor: Ciwon daji (malignant) da wanda ba na ciwon daji ba zai iya shafar jijiyoyi da kansu ko kuma yana iya ƙara matsa lamba akan jijiyoyi da ke kewaye.

Polyneuropathy kuma na iya tasowa sakamakon wasu nau'ikan ciwon daji da ke da alaƙa da amsawar garkuwar jiki.

13- Cututtukan kasusuwa: myeloma saboda osteosclerosis, lymphoma, amyloidosis da sauransu.

14- Sauran cututtuka: sun hada da ciwon koda, ciwon hanta...