Kev tshawb fawb tshiab ntawm kev nce poj niam fertility

Kev tshawb fawb tshiab ntawm kev nce poj niam fertility

Ib tug poj niam txoj kev fertility yuav poob qis pib thaum nws nruab nrab-30s, uas tuaj yeem ua rau nws nyuaj rau kev muaj menyuam hauv nruab nrab hnub nyoog. Ib pab neeg ntawm cov kws tshawb fawb tsis ntev los no tau tshawb pom ib lub tswv yim uas zoo li ua kom cov laus ntawm zes qe menyuam, thiab lawv tau tshawb pom ib txoj hauv kev, tsawg kawg hauv cov nas kom deb li deb, kom nws qeeb kom txhawb kev xeeb tub tom qab lub neej, raws li New Atlas, hais txog phau ntawv Journal Nature Aging.

Disadvantages ntawm artificial insemination

Tsis muaj lub cev muaj hnub nyoog tib yam, thiab hmoov tsis zoo lub zes qe menyuam yog ib lub hauv nruab nrog cev kom raug qhov tshwm sim no sai tshaj plaws, tab sis cov kws tshawb fawb tsis paub meej tias yog vim li cas. Pib thaum muaj hnub nyoog 35 xyoos, lub zes qe menyuam muaj hnub nyoog sai dua, ua rau txo qis qe zoo thiab ua tiav hauv cev xeeb tub. Ntau tus neeg mob siv rau kev siv tshuaj tua kab mob, tab sis nws yog ib txoj hauv kev uas yuav kim thiab ua rau muaj kev pheej hmoo tshiab.

CD 38 noob

Hauv txoj kev tshawb fawb tshiab, cov kws tshawb fawb ntawm Zhengzhou University hauv Suav teb tau tshawb xyuas cov txheej txheem lom neeg uas tuaj yeem ua raws li qhov kev poob qis no. Lawv tau txheeb xyuas cov qauv ntawm cov noob hauv cov nas me, txog li ob lub hlis, thiab cov nas hnub nyoog nruab nrab, txog yim hli, hauv zes qe menyuam thiab lwm yam kabmob.

Cov kws tshawb nrhiav pom tias hauv cov nas laus, kev qhia ntawm cov noob hu ua CD38 nce, tshwj xeeb tshaj yog nyob rau hauv zes qe menyuam. Qhov no tsis yog qhov xav tsis thoob, vim CD38 yog qhov paub zoo txog biomarker ntawm kev laus, vim tias nws tsim cov enzyme uas ua rau cov protein hu ua NAD +, uas tom qab pom muaj qis dua hauv cov nas laus.

Qhov zoo ntawm cov qe thiab qe

NAD protein, thiab nws daim ntawv oxidized NAD +, tswj cov cell metabolism thiab kho DNA, thiab ib txwm poob nrog lub hnub nyoog. Cov qib siab dua tau cuam tshuam nrog kev ua neej nyob ntev thiab kev noj qab haus huv zoo dua li ib lub hnub nyoog, yog li nws tau dhau los ua qhov tseem ceeb ntawm kev tshawb fawb txog kev laus niaj hnub no, nrog qee qhov txiaj ntsig zoo. Nws tam sim no pom tias qhov laj thawj no kuj yog qhov ua rau muaj hnub nyoog ntsig txog kev poob qis hauv fertility.

"Qhov no depletion ntawm [NAD +] sawv cev rau ib tug series ntawm kev phiv, tshwj xeeb tshaj yog cuam tshuam rau qhov zoo ntawm somatic hlwb thiab qe, yog li ua rau muaj kev cuam tshuam loj heev rau poj niam fertility," said Qingling Yang, tus kws tshawb fawb ntawm txoj kev tshawb fawb tshiab.

Tshawb nrhiav nas

Hauv kev soj ntsuam tom qab, pab pawg tau tshem tawm CD38 noob hauv cov nas laus - thiab paub tseeb, cov txiaj ntsig tau ntau dua, cov qe zoo dua. Cov kws tshawb fawb tom qab ntawd pib sim sim seb puas muaj cov txiaj ntsig zoo sib xws tuaj yeem ua tiav yam tsis muaj kev tshuaj ntsuam genetic engineering, ua kom nws muaj peev xwm kho tau zoo dua.

kev sim tshuaj

Tsis tas li ntawd, cov kws tshawb fawb tau tig mus rau lub molecule hu ua 78c, uas inhibits CD38, thiab tau muab nws rau yim hli-hli kuaj nas ib txwm muaj. Tseeb txaus, NAD + qib nce hauv zes qe menyuam, thiab cov nas tuaj yeem yug tau ntau dua.

Kev sim tshuaj ntsuam xyuas tam sim no tab tom ua los saib seb puas txhawb NAD + qib hauv cov poj niam uas tau txais kev pab kho menyuam yaus tuaj yeem txhim kho qhov kev vam meej thiab txo qis kev pheej hmoo ntawm kev yug me nyuam.

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