Tuam Tshoj muab kev tiv thaiv ua ntej tiv thaiv tus kab mob Corona tshiab

Tuam Tshoj muab kev tiv thaiv ua ntej tiv thaiv tus kab mob Corona tshiab

Cov kws tshawb fawb hauv Suav teb tau tsim cov tshuaj tiv thaiv hmoov uas tau muab tshuaj ua ib zaug los ntawm kev nqus tau ncaj qha rau hauv lub ntsws kom tsim tau lub cev tiv thaiv kab mob. Cov tshuaj tiv thaiv tuaj yeem nthuav tawm ntau yam antigens, uas txhais tau hais tias ib koob tshuaj tuaj yeem muab kev tiv thaiv dav dav rau ntau tus kab mob ua pa, raws li qhov tau tshaj tawm los ntawm New Atlas lub vev xaib, hais txog Nature phau ntawv xov xwm.

Tsawg cuam tshuam rau kev kis tus kab mob

Kev tuaj txog ntawm COVID-19 kis thoob qhov txhia chaw tau ua rau muaj kev nce qib hauv cov cuab yeej tshuaj tiv thaiv, suav nrog cov tshuaj tiv thaiv mRNA tam sim no, feem ntau yog muab los ntawm kev txhaj tshuaj rau hauv caj npab lossis cov leeg, tsim kev tiv thaiv kev lom zem, piv txwv li cuam tshuam nrog lub cev kua thiab tso siab rau cov tshuaj tiv thaiv kab mob. neutralize tus kab mob tab sis tsis tiv thaiv kab mob. Thaum txhaj tshuaj tiv thaiv kab mob rau SARS-CoV-2 tau pom tias txo qis kev mob thiab kev tuag, lawv muaj kev cuam tshuam tsawg dua ntawm kev kis tus kabmob.

Kev tswj tus kab mob ntxov ntxov

Kev tsim cov tshuaj tiv thaiv kab mob hauv cov ntaub so ntswg mucosal ntawm txoj hlab pa yog qhov tseem ceeb rau kev tswj hwm tus kab mob thaum ntxov thiab tuaj yeem tsim kev tiv thaiv kab mob ntev thiab ntev nrog cov lus teb rov qab sai. Txhawm rau daws cov teeb meem cuam tshuam nrog cov tshuaj tiv thaiv, cov kws tshawb fawb los ntawm Lub Tsev Haujlwm ntawm Txheej Txheem Engineering ntawm Suav Academy ntawm Kev Tshawb Fawb tau tsim ib qho tshuaj tiv thaiv cov hmoov qhuav qhuav.

Microspheres thiab nanoparticles

Lub platform tshiab tshuaj tiv thaiv ua ke ua ke biodegradable microspheres nrog cov protein nanoparticles, qhov chaw uas tuaj yeem pom ntau yam antigens, tshuaj uas ua rau lub cev tsis muaj zog los tsim cov tshuaj tiv thaiv. Lub xub ntiag ntawm ntau tshaj ib qho antigen nthuav dav ntau yam kev tiv thaiv kab mob los ntawm cov tshuaj tiv thaiv thiab ua rau muaj kev tiv thaiv kab mob dav dav. Piv txwv li, nws tuaj yeem suav nrog antigens los ntawm ntau hom SARS-CoV-2 lossis SARS-CoV-2 ua ke nrog lwm cov tshuaj tiv thaiv kab mob ua pa.

Humoral thiab cellular tiv thaiv

Thaum cov antigen nanoparticles tso tawm, lub ntsws tuaj yeem nqus tau zoo. Vim hais tias nanoparticles raug tso tawm kom ruaj khov, lawv muab kev lom zem ntev, cellular, thiab mucosal tiv thaiv nrog ib koob txhaj tshuaj. Cov kws tshawb fawb tau sim lawv cov tshuaj tiv thaiv hmoov hauv cov nas, cov tsiaj sim, thiab cov khoom tsis yog tib neeg, thiab tau soj ntsuam cov tshuaj tiv thaiv kab mob zoo thiab cov lus teb T-cell hauv zos, ua rau pom kev tiv thaiv kab mob zoo.

Clinical translation los sai sai no

"Cov khoom siv ntawm cov nanosystem me no siv cov proteins thiab cov khoom siv polymeric pom zoo, thiab kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj tiv thaiv tau raug tshawb fawb hauv cov tsiaj txhu uas tsis yog tib neeg, qhia tias nws muaj peev xwm zoo rau kev txhais lus kho mob," Wei Wei, ib tus kws tshawb fawb. hauv kev kawm.

Los ntawm kev tsim khoom, qhov tseeb tias cov tshuaj tiv thaiv yog cov hmoov qhuav txhais tau hais tias nws tsis tas yuav tsum tau tub yees, uas txo cov nqi khaws cia thiab kev thauj mus los thiab ua rau nws tsim nyog siv rau hauv thaj chaw uas tsis muaj lossis txwv cov tub yees.

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