Kev tiv thaiv hyperactivity

Ua tsis taus pa luv tshwm sim hauv cov neeg mob hawb pob vim bronchitis. Qhov tseem ceeb, nws yog ib qho kev tiv thaiv kab mob ntau dhau los teb rau cov tshuaj tsis haum xws li plua plav, pa luam yeeb, muaj kuab paug lossis lwm yam stimuli.

Nws yog ib qho tseem ceeb uas cov kev tshawb fawb yav dhau los tsom rau cov protein hu ua JAK1, uas ua lub luag haujlwm tseem ceeb hauv kev txhawb lub cev tiv thaiv kab mob los ntawm kev xa cov cim rau lub cev tiv thaiv kab mob hu ua phagocytes uas tshem tawm lub cev txawv teb chaws.

Tab sis txawm tias nws qhov tseem ceeb, JAK1 qee zaum tuaj yeem dhau los ua kom muaj zog thiab overstimulate macrophages, ua rau mob, uas tuaj yeem pom nyob rau hauv ntau yam mob, xws li Crohn tus kab mob, rheumatoid mob caj dab thiab hawb pob. Janus kinase inhibitors, lossis JAKs, tau tshwm sim los ua kev kho mob rau cov mob no.

Molecular "itaconate"

Hauv txoj kev tshawb fawb tshiab, Trinity University cov kws tshawb fawb tau txheeb xyuas qhov inhibitor ntawm JAK, uas yog tsim los ntawm tib neeg lub cev. Lub molecule, lub npe hu ua itaconate, tau tshawb pom los ua ib yam ntawm kev tua cov kab mob los ntawm kev muab cov brakes rau overactive macrophages.

Nws kuj hloov tawm los ua JAK1, thiab cov qauv sib xyaw ua ke zoo li tua qhov mob uas pab tiv thaiv mob hawb pob.

kev cia siab

Cov kws tshawb fawb kuj tau sim ib qho itaconate derivative hu ua 4-OI hauv cov qauv nas ntawm mob hawb pob hnyav, uas tsis teb rau cov qauv kev kho mob steroid. Cov molecule tau pom los txo qis kev ua haujlwm ntawm JAK1 inhibitor thiab txo qhov mob hawb pob hauv cov nas.

Dr Marh Runch, tus thawj coj ntawm kev tshawb fawb, tau hais tias: "Muaj kev cia siab siab tias cov tshuaj itaconate-based tshiab tuaj yeem muaj peev xwm ua tau raws li kev kho mob tshiab rau kev kho mob hawb pob hnyav, qhov uas yuav tsum tau kho sai sai rau kev kho mob tshiab."