Kulonjeza chithandizo cha majini kuti abwezeretse kumva kwa ana osamva

Kulonjeza chithandizo cha majini kuti abwezeretse kumva kwa ana osamva

Kuyesa kwachipatala kwapamwamba pogwiritsa ntchito gene therapy kwabwezeretsa kumva kwa ana asanu obadwa osamva. Pambuyo pa miyezi isanu ndi umodzi, anawo anatha kuzindikira zolankhula ndi kuchita zokambitsirana, kudzetsa chiyembekezo cha kugwiritsiridwa ntchito kwake kwakukulu posachedwapa, malinga ndi zimene zinafalitsidwa ndi webusaiti ya New Atlas, kutchula magazini ya Science Advances.

Cholowa

Odwala mu mayeserowa anavutika ndi chibadwa chotchedwa autosomal recessive deafness 9 (DFNB9), yomwe imabwera chifukwa cha kusintha kwa jini yotchedwa OTOF, yomwe imapanga mapuloteni otoferlin, omwe amathandiza kutumiza mphamvu zamagetsi kuchokera ku cochlea kupita ku ubongo, kumene zingatheke. kutanthauziridwa ngati mawu - koma popanda izo. Chifukwa zimayambitsidwa ndi kusinthika kumodzi ndipo sizimawononga ma cell, gululi likuti DFNB9 ndiye woyenera kulandira chithandizo chamtundu wotere.

Mu kafukufuku wopangidwa ndi ofufuza ochokera ku Harvard Medical School, Massachusetts Eye and Ear, ndi Fudan ku China, chithandizo cha majini chimaphatikizapo kulongedza jini ya OTOF mu zonyamulira ma virus ndikubaya kusakaniza kumadzimadzi am'khutu. Kenako ma virus amafufuza ma cell mu cochlea ndikulowetsamo jini, kuwalola kuti ayambe kupanga puloteni yosowa ya autoferlin ndikubwezeretsa kumva.

Kuyika kwa Cochlear

Ana asanu ndi mmodzi, azaka zapakati pa chaka chimodzi ndi zisanu ndi ziwiri, omwe DFNB9 idawasiya osamvanso adachita nawo kafukufukuyu. Odwala anayi anaikidwa ma implants a cochlear, amene analambalala vutolo ndi kuwalola kuphunzira kuzindikira malankhulidwe ndi mamvekedwe ena. Pamenepa, zoikamo zinaimitsidwa.

kuwongolera kodabwitsa

Pambuyo pa chithandizo cha majini, anawo adatsatiridwa kwa milungu 26. Panthaŵiyo, asanu mwa asanu ndi mmodzi mwa asanu ndi mmodzi anasonyeza kuwongolera kwakukulu, ndi ana okulirapo atatuwo anatha kumvetsetsa ndi kulabadira zolankhula, pamene aŵiri anatha kuzinyamula m’chipinda chaphokoso ndi kukambitsirana pa foni. Ena mwa anawo anali aang’ono kwambiri kuti ayesedwe, koma anapezeka kuti amayankha mamvekedwe, ndipo anayambanso kunena mawu osavuta monga akuti “amayi.” Kuwongolerako kudachitika pang'onopang'ono, koma gululo linanena kuti anawo adayamba kuwonetsa zotsatira mayeso oyamba asanachitike masabata anayi pambuyo pake.

Zomwe zimayambitsa chibadwa komanso ukalamba

Yilai Xu, yemwe ndi wotsogolera kafukufukuyu, adanena kuti omwe atenga nawo mbali pachiyesochi apitirizabe kuyang'aniridwa, pamene maphunziro otsatila adzachitidwa kwa anthu ena. Gululo likuti kuvomereza chithandizo ku United States kungatenge pakati pa zaka zitatu mpaka zisanu. Njira zochiritsira za majini zofananira zayesedwa kuti zikhale ndi vuto lakumva chifukwa cha chibadwa kapena zaka.

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