Kodi pali ubale wotani pakati pa chikhalidwe chamalingaliro ndi m'matumbo amanjenje?

Kodi pali ubale wotani pakati pa chikhalidwe chamalingaliro ndi m'matumbo amanjenje?

IBS nthawi zambiri imatsagana ndi zizindikiro za m'mimba m'matumbo aang'ono ndi aakulu. IBS idagawika m'magulu anayi kutengera chimbudzi cha asymmetry mwachitsanzo IBS yokhala ndi kudzimbidwa IBS-C, ndi kutsekula m'mimba IBS-D, yosakanikirana IBS-M, kapena IBS yosadziwika.

Komabe, pali kusamvetsetsa m'mabuku asayansi okhudzana ndi njira ndi machiritso a IBS, zomwe zimachitika chifukwa cha kusowa kwa zitsanzo zothandiza za nyama zoyesera.

Kwa zaka zambiri, kafukufuku wasonyeza kulumikizana pakati pa kukhudzidwa kwamalingaliro ndi kusagwira ntchito kwamatumbo, ndikugogomezera kukhalapo ndi kufunikira kwa zomwe zimatchedwa "gut axis" pakuzindikira kukhulupirika kwamalingaliro ndi chakudya choyimira.

Zovuta za kugonjetsedwa kwa anthu

Posachedwapa, cSDS stressors ndi cVSDS stressors amavomerezedwa ngati zitsanzo za MDD ndi PTSD.

Kuti tiyankhe funsoli: “Kodi zitsanzo za nyama zogonja kwa kanthaŵi kochepa zingathandize kumvetsetsa IBS mwatsatanetsatane?” Ofufuza a ku TUS, motsogozedwa ndi Pulofesa Akiyoshi Saitoh wa College of Pharmaceutical Sciences, anagwiritsa ntchito zitsanzo za mbewa kuti amvetsetse zotsatira za kupsinjika kwanthaŵi yaitali pa matenda. M'mimba.

Ofufuzawa adapeza kuti mbewa zopsinjika maganizo zimawonetsa maulendo apamwamba a m'mimba komanso makhalidwe okhudzana ndi ululu wa visceral, zomwe ndi zizindikiro za IBS.

kupsinjika kwakuthupi kapena kwamalingaliro

Pulofesa Saitoh akunena kuti cholinga cha phunziroli chinali "pachitsanzo cha kugonjetsedwa kwakanthawi kochepa kwa chikhalidwe cha anthu komanso zotsatira za kupsinjika maganizo pa matenda a m'mimba adawunikidwa, kuphatikizapo kuwunika momwe chitsanzocho chingathere ngati nyama yatsopano ya IBS."

Pakufufuza kwawo, ochita kafukufukuwo adawonetsa mbewa kupsinjika kwakuthupi kapena m'maganizo, monga nyama zoyesera zinkachitidwa nkhanza zakuthupi kapena zamaganizo kwa mphindi 10 patsiku kwa masiku 10 otsatizana.

mayeso okhudzana ndi anthu

Pa tsiku la khumi ndi limodzi, mayesero okhudzana ndi chikhalidwe cha anthu adachitidwa kuti awone zovuta za nyama zoyesera. Kupsinjika maganizo kunayesedwanso poyerekezera kuchuluka kwa corticosterone mu plasma, ndi kuyesa njira ya chakudya cha makala kudzera m'matumbo. Ofufuzawo adawunikanso mbewa kuti azitha kulowa m'matumbo, kutulutsa pafupipafupi, komanso chimbudzi.

Zinapezeka kuti kuchuluka kwa mayendedwe a malasha, omwe akuwonetsa kudutsa m'matumbo, anali apamwamba kwambiri mu mbewa zomwe zimakhudzidwa ndi kupsinjika maganizo poyerekeza ndi mbewa mu gulu lolamulira, lomwe silinayambe kupsinjika maganizo. Koma zotsatira zake zinali zochepa mu mbewa, zomwe zinkakhala ndi nkhawa zakuthupi. Kuchuluka kwa chimbudzi ndi madzi omwe ali m'chimbudzi anawonjezekanso mu makoswe omwe amakhudzidwa ndi kupsinjika maganizo.

Irritable Bowel Syndrome

Zotsatirazi zinapitirira kwa mwezi wa XNUMX mutatha kupsinjika maganizo, kuwonjezera apo, panalibe kusiyana kwakukulu kwa matenda ndi matumbo a m'matumbo pakati pa gulu lolamulira kapena gulu lopsinjika maganizo, zomwe zimasonyeza kuti palibe kusintha kwa minofu chifukwa cha kupsinjika maganizo.

"Zotsatirazi zimasonyeza kuti mu mbewa zosautsa zimabweretsa zizindikiro za IBS ndi IBS-D, monga kuwonjezereka kwa m'mimba ndi m'mimba hyperalgesia, popanda kukhalapo kwa zilonda zam'mimba," anatero Pulofesa Saitoh.

Cholemba chodabwitsa

Chochititsa chidwi n'chakuti, ofufuzawo adapeza kuti kusintha kwamatumbo a m'matumbo mu zinyama zoyesera kumayenda bwino pamene mbewa za cVSDS zimathandizidwa ndi mankhwala omwe amagwiritsidwa ntchito kuchipatala ku IBS.

Kafukufukuyu akuwonetsa ubwino wa chitsanzo cha cVSDS kuposa njira zachikhalidwe zokopa zizindikiro za IBS-D-D-monga kukumana ndi kupsinjika maganizo mobwerezabwereza.

Udindo wa cerebral cortex

Ponena za momwe zimakhalira ndi zotsatirazi, Pulofesa Saitoh akuti: "Kuchokera ku matumbo a ubongo, akuganiza kuti cortex imagwira ntchito yofunika kwambiri pa phenotyping mbewa zopsinjika maganizo." The insular cortex ndi gawo lapamwamba la mitsempha yapakati yomwe imayang'anira ntchito za m'mimba ndipo imakhudzidwa ndi njira yothetsera vuto la maganizo.

Kuphatikiza apo, kafukufukuyu akuwonetsa, kwa nthawi yoyamba, kuti kupsinjika kwamaganizidwe komwe kumachitika ndi cVSDS kokha kungayambitse zizindikiro za IBS-D mu mbewa, kotero kuti kafukufuku wopitilira pamitundu ya cSDS ndi cVSDS atha kufotokoza mwatsatanetsatane. motero kupanga mankhwala a Irritable Bowel Syndrome.