Zomwe zimayambitsa matenda a ubongo ndi Alzheimer's

Zomwe zimayambitsa matenda a ubongo ndi Alzheimer's

Kafukufuku waposachedwa wasayansi adawonetsa kuti matenda ena obwera chifukwa cha ma virus amatha kuyambitsa matenda a neurodegenerative monga matenda a Alzheimer's ndi Parkinson's.

Kafukufukuyu, wofalitsidwa ndi tsamba la zaumoyo la Boldsky, akutchula nyuzipepala ya Nature Communications, akuchokera ku mayesero a labotale omwe amasonyeza kuti tizilombo tina ta tizilombo toyambitsa matenda timathandizira kufalikira kwa magulu a mapuloteni omwe ndi chizindikiro cha matenda a ubongo.

Matenda a Prion

Gulu la ofufuza, ochokera ku yunivesite ya Bonn, ku Germany, adawona kuti magulu a mapuloteni opotoka, omwe amapezeka mu otchedwa prion matenda, amatha kuchoka ku selo imodzi kupita ku ina, kumene amasamutsa mawonekedwe awo achilendo ku mapuloteni. amtundu womwewo.

Chotsatira chake, matendawa amafalikira kudzera mu ubongo, ofufuzawo adanena, ndipo chinthu chofananacho chimapezeka mu matenda a Alzheimer's and Parkinson's disease. Kusamutsidwa kwa aggregates kungaphatikizepo mwachindunji selo kukhudzana ndi selo, kutulutsidwa kwa "maliseche" agglomerates mu extracellular danga kapena phukusi mu vesicles, amene ndi thovu ang'onoang'ono atazunguliridwa ndi zamadzimadzi m'chimake kuti zobisika kwa intercellular kulankhulana.

"Njira zenizeni zopatsirana sizikudziwika," adatero Prof. Anna Voorberg, pulofesa wa yunivesite ya Bonn.

Kuyerekeza zotsatira za matenda a virus

Potengera zomwe zimachitika chifukwa cha matenda a virus, ofufuzawo adalimbikitsa ma cell kuti apange ma virus omwe amalumikizana ndi ma cell komanso kuphatikiza kwa membrane.
Mitundu iwiri yamapuloteni idasankhidwa kuphatikiza mapuloteni a spike SARS-CoV-2, omwe amachokera ku kachilombo komwe kamayambitsa COVID-19, ndi vesicular stomatitis virus VSV-G glycoprotein, yomwe imapezeka mu tizilombo toyambitsa matenda ng'ombe ndi nyama zina.

Maselo amawonetsa ma receptor a mapuloteni awa, banja la LDL receptor, lomwe limakhala ngati ma niches okhazikika a VSV-G, komanso cholandilira cha ACE2, chomwe ndi cholandirira cha SARS-CoV-2.

"Titha kuwonetsa kuti ma virus amapangidwa mu cell membrane ndi ma vesicles akunja," adatero Pulofesa Forberg.

Ananenanso kuti "kukhalapo kwake kumawonjezera kufalikira kwa mapuloteni ochuluka pakati pa maselo, kaya kudzera m'ma cell kapena ma vesicles akunja."

Ma ma viral ligand adathandizira kusamutsa kokwanira kwa magulu ophatikizika kupita ku ma cell omwe amalandila, komwe adalimbikitsa magulu atsopano. "Malumikizidwewo amakhala ngati masiwichi omwe amatsegula ma cell omwe amalandila ndikulowa m'malo oopsa," adatero Pulofesa Forberg.

Kulumikizana kwa ma virus protein receptor

Ponseponse, deta ikuwonetsa kuti kuyanjana kwa ma viral ligand-receptor kumatha kukhudza kufalikira kwa mapuloteni oyambitsa matenda.

Prof. Forberg anati: “Nthawi zina muubongo wa odwala omwe ali ndi matenda a neurodegenerative amakhala ndi ma virus ena. Amaganiziridwa kuti amayambitsa kutupa kapena kukhala ndi poizoni, ndipo motero amafulumizitsa njira ya neurodegeneration," ponena kuti "mapuloteni a tizilombo amatha kuchita mosiyana, chifukwa angapangitse kuchulukana kwamagulu a mapuloteni omwe alipo kale mu matenda a neurodegenerative." Matenda a Alzheimer's.

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