Kodi zakudya za keto zikukhudzana bwanji ndi kupewa kudwala matenda a dementia?

Kodi zakudya za keto zikukhudzana bwanji ndi kupewa kudwala matenda a dementia?

Kudya zakudya za keto kumalepheretsa kusokonezeka kwa chidziwitso chochepa, chomwe nthawi zambiri chimawonekera kumayambiriro kwa matenda a Alzheimer's, mwa kusintha momwe maselo a ubongo amalumikizirana ndi kulankhulana, kafukufuku watsopano amapeza. Ofufuza akuwonetsa kuti kutengera zakudya za keto kungakhale njira yochepetsera kuyambika kwa matenda a Alzheimer's.

Zambiri zabwino

Chakudya cha ketogenic ndi chochepa kwambiri cha carb, mafuta ambiri, kapena mapuloteni ocheperako akadali kutsutsana. Koma kafukufuku angapo apeza kuti keto imatha kutalikitsa moyo, kuteteza ku khunyu, komanso kuwonjezera zotsatira za mankhwala amphamvu.

Zotsatira za kafukufuku watsopano, wochitidwa ndi ofufuza a ku yunivesite ya California, akhoza kuwonjezera mndandanda wa zabwino za zakudya za ketogenic. Ofufuzawa adapeza kuti kudya zakudya za keto, makamaka mbewa, kunachedwetsa kwambiri kuwonongeka kwachidziwitso komwe kumawoneka koyambirira kwa matenda a Alzheimer's powonjezera kuchuluka kwa molekyulu ya beta-hydroxybutyrate (BHB).

Kuchedwetsa kuyambika kwa Alzheimer's

"Deta imachirikiza lingaliro lakuti zakudya za ketogenic mwachizoloŵezi, ndi BHB makamaka, zimachedwetsa kusokonezeka kwachidziwitso pang'ono, zomwe zingachedwetse matenda a Alzheimer," anatero Gino Cortobasi, mmodzi mwa ofufuza a kafukufukuyu, ponena kuti "detayi siili bwino. thandizirani lingaliro lakuti Zakudya za keto zimatsogolera ku kuthetseratu matenda a Alzheimer's."

Zaka 103 zapitazo

Zakudya za keto zidayamba mu 1921 ngati njira yopondereza khunyu, ndipo ngakhale njira yake yochitira zinthu imakhalabe yodabwitsa, imakhalabe njira yochizira khunyu, makamaka ngati kukomoka sikungalandire chithandizo. Posachedwapa, yafufuzidwa ngati njira yopititsira patsogolo luso lachidziwitso ndi kuchepetsa zizindikiro za matenda a ubongo monga Parkinson's disease ndi amyotrophic lateral sclerosis.

Njira ina yopangira mphamvu

Cholinga cha zakudya ndikusiya kugwiritsa ntchito shuga monga gwero lalikulu lamafuta m'thupi ndikuyamba kuyatsa mafuta kuti apange mphamvu. Pamene masitolo a glucose ali otsika kwambiri chifukwa cha zofunikira za thupi, zomwe zimachitika ndi zakudya za keto, chifukwa cha zakudya zochepa kwambiri zomwe zimapatsa shuga, ndiye kuti chiwindi chimaphwanya mafuta acids kukhala ma ketoni, kuphatikizapo BHB. Ziwalo zambiri ndi minyewa, kuphatikiza ubongo, zimatha kugwiritsa ntchito ma ketoni ngati gwero lina lamphamvu.

13% moyo wautali

Pakafukufuku waposachedwa, ofufuzawo adakulitsa kafukufuku wawo wam'mbuyomu, omwe adapeza kuti mbewa zimakhala nthawi yayitali 13% pazakudya za keto, kuti awone momwe ubongo wa mbewa umayankhira pazakudya za keto. Ofufuzawa adadyetsa mbewa za labotale za matenda a Alzheimer's keto kwa miyezi isanu ndi iwiri ndikuwunika kukumbukira kukumbukira ndi synaptic plasticity, komwe ndiko kuthekera komwe ma neuroni amalumikizana ndikulumikizana kuti asinthe mawonekedwe awo ndi / kapena ntchito.

Molekyu ya Beta hydroxybutyrate

Atatha kudya keto chakudya, milingo yozungulira beta-hydroxybutyrate (BHB) inakula kwambiri mu mbewa zamphongo ndi zazikazi poyerekeza ndi gulu lolamulira. M'malo osala kudya, ma BHB anali apamwamba kuposa omwe amadyetsedwa komanso apamwamba kwambiri mwa akazi.

Memory yosungirako makina

Ochita kafukufuku atafufuza ubongo wa mbewa zodyetsedwa ndi keto, adapeza kuti makina osungira kukumbukira kukumbukira "anapulumutsidwa." Majini okhudzana ndi pulasitiki ya synaptic adayendetsedwa, koma palibe kuchepa kwa zolembera za beta-amyloid, chizindikiro cha matenda a Alzheimer's. Zotsatira zikuwonetsa kuti njira yazakudya - kapena BHB - inali kupulumutsa chidziwitso ndi kukumbukira pokonzanso synaptic plasticity.

"Maluso odabwitsa a BHB awonedwa kuti apititse patsogolo ntchito ya ma synapses, omwe ndi tinthu tating'onoting'ono tomwe timagwirizanitsa minyewa yonse muubongo," adatero Izumi Maezawa, wofufuza wina yemwe adachita nawo kafukufukuyu, akufotokoza kuti "pamene ma neurons amalumikizana bwino, kukumbukira. mavuto amakula m’kufooka.” “Kuzindikira mozama.”

Imapezeka ngati chowonjezera chazakudya

Molekyu ya BHB imakhalapo kuti igulidwe ngati chakudya chowonjezera, koma ochita kafukufuku akuchenjeza kuti panthawiyi, zotsatira za BHB pa kukumbukira makoswe ndi chidziwitso cha chidziwitso sichinatsimikizidwe, kotero kutenga zowonjezera za BHB mochuluka siziyenera kuchitika panthawiyi. Ngakhale kuti matupi a ketone nthawi zambiri amawonedwa ngati otetezeka, amatha kuyambitsa zotsatira zoyipa monga nseru, kutsegula m'mimba, ndi kupweteka kwa m'mimba. Ma ketoni omwe ali nawo nthawi zambiri amagwirizanitsidwa ndi mchere, sodium, potaziyamu, calcium kapena magnesium, kotero kuti kudya kwambiri sikuvomerezeka.

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