Tsvakurudzo itsva yekuwedzera kubereka kwevakadzi

Tsvakurudzo itsva yekuwedzera kubereka kwevakadzi

Kubereka kwemukadzi kunowanzodzikira kutanga pakati pemakore makumi matatu, izvo zvinogona kuita kuti zvive zvakaoma kuita vana pakati pemakore. Chikwata chemasaenzi munguva pfupi yapfuura chakawana nzira inoita seinomhanyisa kuchembera kwemaovari, uye vakawana nzira, ingangoita mbeva kusvika parizvino, kuti inonoke kuti iwedzere kubereka gare gare muhupenyu, maererano neNew Atlas, ichitaura. magazini inonzi Nature Aging.

Kuipa kwekugadzirwa kwembesa

Hapana nhengo dzinokura pachiyero chakafanana, uye zvinosuruvarisa kuti maovari ndeimwe yenhengo dzinotambura nechiitiko ichi nekukurumidza, asi masayendisiti haana chokwadi zvachose kuti nei. Kutanga kusvika makore makumi matatu nemashanu, maovari anokura nekukurumidza, zvichikonzera kuderera kwemhando yezai uye kubudirira pakubata. Varwere vazhinji vanoshandisa kuisirwa urume, asi inzira inogona kudhura uye inounza njodzi nyowani.

CD38 gene

Muchidzidzo chitsva ichi, masayendisiti epaZhengzhou University kuChina akaferefeta nzira dzebhaibheri dzinogona kunge dziri kukonzera kudzikira uku. Vakaongorora maitiro ekutaura kwemajini mumakonzo madiki, angangoita mwedzi miviri, uye mbeva dzepakati-kati, dzinenge mwedzi misere, mumaovari nedzimwe nhengo.

Vatsvakurudzi vakawana kuti mumakonzo echikuru, kutaura kwejini rinonzi CD38 kwakawedzera, kunyanya mumaovari. Izvi hazvina kushamisa zvachose, sezvo CD38 iri inozivikanwa biomarker yekuchembera, nekuti inoburitsa enzyme inopwanya puroteni inonzi NAD+, iyo yakazowanikwa yakaderera zvakanyanya mumakonzo akura.

Hunhu hwemasero nemazai

NAD protein, uye fomu yayo oxidized NAD +, inogadzirisa sero metabolism uye DNA kugadzirisa, uye inodzikira nezera. Mazinga epamusoro akave akabatana nehupenyu hurefu uye hutano huri nani sezera rimwe, saka yave iyo yekutarisa yemazuva ano anti-kuchembera tsvakiridzo, ine mimwe mhedzisiro inovimbisa. Ikozvino zvave kuita sekuti ichi chikonzero chinowanzoitika ndicho chikonzero chekudzikira kwezera mukubereka.

"Uku kuderera kwe[NAD+] kunomiririra nhevedzano yemhedzisiro yakaipa, kunyanya kukanganisa kunaka kweese somatic masero nemazai, nekudaro zvichipesvedzera zvakanyanya pakubereka kwevakadzi," akadaro Qingling Yang, muongorori pachidzidzo chitsva.

Tsvakurudzo pamakonzo

Mukuedza kwekutevera, timu yakadzima CD38 gene mumakonzo ekare - uye chokwadi zvakakwana, mhedzisiro yaive yakawanda, mazai emhando yepamusoro. Vatsvagiri vakabva vatanga kuyedza kuona kana mhedzisiro yakafanana inogona kuwanikwa pasina genetic engineering, kuita kuti ive inogoneka kurapwa kwembereko.

miedzo yekiriniki

Pamusoro pezvo, vaongorori vakatendeukira kune molekuru inonzi 78c, iyo inovharira CD38, uye yakapihwa kumakonzo ane mwedzi misere ekuzvarwa. Chokwadi zvakakwana, mazinga eNAD + akawedzera mumaovari, uye mbeva dzakakwanisa kubereka zvimwe.

Miedzo yemakiriniki parizvino iri kuitwa kuti vaone kana kuwedzera NAD+ mazinga muvakadzi vanobatsirwa kurapwa kubereka kunogona kuvandudza budiriro uye kuderedza njodzi yekuremara kwekuzvarwa.

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