Kurapa kunovimbisa varwere veParkinson

Kurapa kunovimbisa varwere veParkinson

Chirwere cheParkinson chirwere chisingaperi chine neurodegenerative chinokanganisa masero etsinga anoburitsa dopamine, kemikari inotumira masaini pakati penzvimbo dzehuropi.

Dopamine zvakare inokonzeresa kufamba kwakatsetseka uye kwakarongeka kwemhasuru dzemuviri. Uye kana mazinga ayo atanga kudzikira, izvi zvinokanganisa mafambiro emuviri.

Kunyange zvazvo pasina mushonga wechirwere cheParkinson, kune marapiro anobvisa zviratidzo, kusanganisira mishonga, kurovedza muviri kunoramba kuchiita uye marapirwo echisikigo anotarisa pakuenzanisa uye kutambanudza, nezvimwewo.

Genetically modified mabhakitiriya

Asi tsvakiridzo itsva, yakapihwa pamusangano wepagore weAmerican Society for Experimental Pharmacology and Therapeutics muPhiladelphia, inogona kupa tariro kuvarwere mushure mekunge yaratidza kuti mabhakitiriya akagadziriswa majini anogona kuve mushonga unoshanda weParkinson.

Muchidimbu, vaongorori vakagadzira mabhakitiriya anogona kugadzira chitubu chakagadzikana chemishonga mukati memurwere, uye bvunzo dzemhuka dzakaratidza kuti dzakachengeteka uye dzinoshanda, maererano neNew Atlas.

Pfungwa yeinjiniya mabhakitiriya kushanda sekurapa haisi itsva. Kwemakore mazhinji, masayendisiti akatoedza nzira dzekugadzirisa mabhakitiriya kuti aenderane nezvinodiwa nevanhu, kubva muuinjiniya hutachiona kusvika kukwidza ammonia mumuviri wemunhu kubatsira mabhakitiriya kuronda maseru egomarara remukati.

dambudziko rakasiyana

Asi chokwadi, zano rakadai risati ragadzirira kushandiswa kwekiriniki kwakajairika, zvipingamupinyi zvakati wandei zvinofanirwa kukurirwa.

Kupa mishonga inodzorwa yemishonga kumurwere nenzira yemapiritsi, majekiseni kana majekiseni zvinozivikanwa. Asi kudzikisira kukura kwehutachiona hwehupenyu hwakagadzirwa kuti hugadzire iwo mamwe mamorekuru ekurapa mudumbu remunhu kunopa dambudziko rakasiyana zvachose.

Zvishoma nezvishoma enda mberi

Tsvagiridzo itsva iyi yakatora danho rekuwedzera kumberi muinjiniya rudzi rutsva rwevanhu probiotic E.coli Nissle 1917, iyo yakagadzirwa kugadzira nekuramba ichibaya mushonga weParkinson's disease unozivikanwa seL-DOPA muura hwemurwere.

L-DOPA imorekuru inoita seyakatangira dopamine uye yanga iri kurapa kwakabudirira kwevarwere veParkinson kwemakumi emakore. Asi vanachiremba vakaona kuti anenge makore mashanu mushure mekunge varwere vagamuchira mushonga uyu, vanowanzoita mhedzisiro inozivikanwa se dyskinesia. Izvi zvinokonzeresa zvinofungidzirwa kuti zvine chekuita nekushaikwa kweinoenderera sosi yekupihwa kwezvinodhaka kuuropi.

Saka kugadzirisa nyaya iyi, tsvakiridzo nyowani yakaongorora kana mabhakitiriya anoburitsa L-DOPA mumatumbu anogona kutungamira mukufambiswa kwezvinodhaka kuuropi.

mari yekurapa inoshanda

Utachiona hwakagadzirwa hunokwira molecule inonzi tyrosine uye inoburitsa L-DOPA mudumbu remurwere, akadaro Piyush Badi, munyori-pamwe pachidzidzo ichi.

Pamusoro pezvo, zviedzo zvakawanda mumakonzo zvakaratidza kuti mabhakitiriya akagadzirwa nemajini akakonzera kugadzikana uye kunoenderana kudzika kweL-DOPA muropa. Zvino miedzo mumhando dzemhuka dzechirwere cheParkinson yakaona kuti kurapwa kwakavandudza mota nemashandiro ekuziva, zvichiratidza kuti mabhakitiriya akagadzirwa aigadzira huwandu hunoshanda hwemushonga.

Alzheimer's uye depression

Vatsvakurudzi vanotiwo mazinga eL-DOPA anogadzirwa nebhakitiriya anogona kunyatsodzorwa, kungave nekuderedza madhasi emazuva ese ebhakitiriya anodyiwa mumakapisi kana nekugadzirisa kushandiswa kweshuga inonzi rhamhose, iyo bhakitiriya inoda kuramba ichigadzira. L-DOPA.

Anumantha Kanthasamy, zvakare munyori-mubatsiri wechidzidzo ichi, akati boka revasayendisiti parizvino riri kushanda pakugadzirisa nzira yekurapa zvimwe zvirwere zvinoda kuramba uchipihwa mishonga, senge Alzheimer's uye depression.