Kudya nyama yakawandisa kunokonzera gomarara remuura here?

Kudya nyama yakawandisa kunokonzera gomarara remuura here?

Chikwata chevatsvakurudzi muUnited States chakabudirira kuwana kubatana pakati pekudya tsvuku nenyama yakagayiwa uye kuitika kwegomarara remudumbu.

Vatsvagiri vakawana ma genetic mamaki maviri anogona kutsanangura njodzi yakawedzera yegomarara rekoloni, asi kwete hwaro hwehupenyu. Kunzwisisa maitiro echirwere uye majini ari shure kwayo anogona kubatsira kugadzira nzira dzekudzivirira dziri nani.

Kuwanda kwegomarara remuura

Zvinoenderana nezvakadhindwa neNew Atlas, ichitaura mugwaro reCancer Epidemiology, Biomarkers & Prevention, colorectal cancer, inozivikanwawo sekenza yemudumbu, ndiyo yechitatu mhando yegomarara uye yechipiri inotungamira kukonzeresa kufa kwekenza pasi rese. Zviri zvakare kuwedzera muvanhu vadiki, neAmerican Cancer Society ACS ichishuma kuti makumi maviri muzana evakaongororwa muna 20 vaive muvarwere vari pasi pemakumi mashanu neshanu, izvo zvakapetwa kaviri muyero muna 2019.

The predominant biological mechanism

Kunyangwe kushamwaridzana pakati penyama tsvuku uye kudyiwa nyama yakagadziriswa uye colorectal cancer yave ichizivikanwa kwenguva yakati, iyo yakanyanya biological nzira iri pasi payo haina kuzivikanwa. Muchidzidzo chitsva, vaongorori veYunivhesiti yeSouthern California vakawana kuti zvinhu zviviri zvemajini zvinoshandura huwandu hwengozi yegomarara zvichienderana nekudyiwa kwenyama tsvuku uye yakagadziriswa.

Rimwe boka rinotarisana nenjodzi huru

"Zvabuda zvinoratidza kuti kune boka revanhu vanotarisana nenjodzi huru yekuva negomarara remukati kana vakadya nyama tsvuku kana yakagadzikiswa," akadaro Mariana Stern, anotungamira muongorori, achiona kuti "inobvumira kutarisa kweiyo nzira inogona kumashure. njodzi iyi, iyo "Inogona kuteverwa nezvidzidzo zvekuyedza."

Vatsvakurudzi vakaongorora sampuli yakabatanidzwa ye29842 colorectal cancer kesi uye 39635 zvidzoreso zveEuropean mabviro kubva kuzvidzidzo makumi maviri nenomwe. Vakatanga kushandisa data kubva kuzvidzidzo kugadzira zviyero zvekudyiwa kwenyama tsvuku, nyama yemombe, gwayana, uye nyama yakagadzikiswa senge soseji uye nyama inodyiwa.

Kushandiswa kwezuva nezuva kweboka rimwe nerimwe kwakaverengwa uye kwakagadziriswa maererano nehuwandu hwehuwandu hwemuviri (BMI), uye vatori vechikamu vakakamurwa kuva mapoka mana zvichienderana nemazinga avo ehutsvuku kana nyama yakagadziriswa. Vanhu vane huwandu hwepamusoro hwekudyiwa kwenyama tsvuku uye kushandiswa kwenyama yakagadziriswa vaive 30% uye 40% mukana wekuita cancer cancer, zvichiteerana. Migumisiro iyi haina kufunga nezvekusiyana kwemajini, izvo zvinogona kuisa njodzi huru kune vamwe vanhu.

DNA samples

Kubva pamasampuli eDNA, vaongorori vakaunganidza data kune anopfuura mamirioni manomwe emajini akasiyana anofukidza genome - iyo yakazara seti yedata data - kune mumwe nemumwe anotora chidzidzo. Kuti uongorore hukama pakati pekudya kwenyama tsvuku uye njodzi yekenza, genome-wide gene-environment interaction analysis yakaitwa. Vatsvakurudzi vakabva vaongorora SNPs, iyo inonzi snippets uye ndiyo inowanzosiyana-siyana yemarudzi akasiyana-siyana, kune vatori vechikamu kuti vaone kana kuvapo kweimwe geneti yakasiyana-siyana yakashandura njodzi yekenza yemavara kune vanhu vakadya nyama tsvuku yakawanda. Zvechokwadi, kushamwaridzana pakati penyama tsvuku nekenza kwakashanduka mune mbiri chete yeSNPs yakaongororwa: SNP pakromosome 8 pedyo neHAS2 gene uye SNP pane chromosome 18, iyo inhengo yeSMAD7 gene.

HAS2 gene

Iyo HAS2 gene chikamu chenzira inokodha yekuchinja kweprotein mukati memasero. Zvidzidzo zvekare zvakazvibatanidza negomarara remukati, asi hazvina kumbozvibatanidza nekudyiwa kwenyama tsvuku. Ongororo yevatsvaguri yakaratidza kuti vanhu vane mutsauko wakajairwa wejini rinowanikwa mu66% yesample vaive nenjodzi ye38% yekubatwa negomarara remukati kana vakadya nyama yepamusoro. Mukupesana, avo vane mutsauko usingawanzo siyana wejini rimwe chetero havana kuva nengozi yakawedzera yegomarara apo vakadya nyama tsvuku yakawanda.

SMAD7 gene

Kana iri SMAD7 gene, inodzora hepcidin, puroteni ine chekuita nesimbi metabolism. Chikafu chine marudzi maviri esimbi: heme iron uye isiri-heme iron. Heme iron inotorwa nyore nyore nemuviri, uye inosvika makumi matatu muzana yayo inotorwa kubva muchikafu chinopedzwa. Nekuti nyama dzvuku uye yakagadziriswa ine yakakwira heme iron, vaongorori vakafungidzira kuti akasiyana SMAD30 gene akasiyana anogona kuwedzera njodzi yegomarara nekuchinja mabatiro anoita muviri iron.

Kuwedzera intracellular iron

Stern akati, “Apo hepcidin inokanganisa, inogona kutungamirira kuwedzera kunyura kwesimbi uye kunyange kuwedzera intracellular iron.” Zvakaratidzwa kuti vanhu vane makopi maviri ejeni rakajairika reSMAD7, rinowanikwa munenge 74% yemasampuli, vaiva 18%. % yegomarara remukati kana vakadya nyama tsvuku yakawanda. Nepo avo vaingove nekopi imwe chete yemusiyano wakajairika kana makopi maviri emusiyano ushoma vaive nenjodzi yegomarara yakanyanya inofungidzirwa pa35% uye 46% zvichiteerana. Vatsvagiri vanotarisira kuita zvidzidzo zvekuyedza zvinogona kusimbisa humbowo pane basa reiyo dysregulated iron metabolism mukukura kwegomarara re colorectal.

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