Unyango lwe-acne kunye namalungu kunye !!!

Unyango lwe-acne kunye namalungu kunye !!!

Iqela lezazinzulu ezifuna unyango olutsha lwe-osteoarthritis yesandla lifikelele kwimpumelelo entsha ethembisayo ngexesha lovavanyo lwechiza elaphuhliswa ekuqaleni ukunyanga i-acne kunye ne-psoriasis.

Iingcali zenzululwazi nazo zakwazi ukufumanisa ukuba ichiza linokuthintela ukuphuhliswa kwe-osteoarthritis yesandla kwiimodeli zezilwanyana zaselabhoratri, kwaye ngoku zisebenza ebantwini ukuze ziqinisekise amandla alo njengonyango olutsha lweklinikhi, ngokutsho kwapapashwa yiNew Atlas, ecaphula. ulindixesha Science Translational Medicine.

retinoic acid

Uphando lwenziwe ngoososayensi kwiYunivesithi yaseOxford, abazimisele ukufunda ukwahluka okuqhelekileyo kwijini ebizwa ngokuba yi-ALDH1A2 edityaniswe ne-OA yesandla esinzima. Abaphandi baqinisekisa le khonkco ngokudweba idatha evela kwi-UK Biobank Study, kwaye emva koko bafumana i-articular cartilage kwizigulane ze-33 ze-OA ngelixa benziwa utyando.

Ezi sampuli ziye zaphononongwa kunye neemodeli zovavanyo, eziye zavumela iqela ukuba lichonge imolekyuli ethile eyayiphantsi kakhulu kubantu abasengozini enkulu. Imolekyuli ibizwa ngokuba yi-retinoic acid, kwaye yenziwe yijini ye-ALDH1A2. Ngokulandelelana kwe-RNA, abaphandi bakwazi ukubona ulungelelwaniso phakathi kokwahluka kofuzo, i-asidi ephantsi ye-retinoic, kunye nokudumba okubonwa kwi-OA.

I-acne kunye ne-psoriasis

Abaphandi ke baguqukela kwiyeza elibizwa ngokuba yiTalarozole, elaphuhliswa ukuthintela imetabolism ye-retinoic acid ukunyanga i-acne, i-psoriasis kunye neemeko zolusu ezinxulumene nazo. Xa isetyenziswe emadolweni eemodeli zemouse, iyeza lakwazi ukunciphisa ukulimala kwe-cartilage kunye nokuvuvukala emva kweeyure ezintandathu. Iziphumo ziphinde zaphindwa kwi-ex vivo porcine joints.

I-Osteoporosis kunye neentlungu ezingapheliyo

UGqr Neha Essar-Brown, umbhali-mbhali wolu phando kunye noMlawuli woPhando lwezeMpilo kwiYunivesithi yaseOxford, uthe: "Uphononongo lusekwinqanaba lokuqala, kodwa ngezi ziphumo zikhuthazayo, silinyathelo elikhulu elikufutshane ukuze sikwazi ukuphuhlisa. iklasi entsha yamachiza okulungisa ukunyanga i-osteoporosis.

Ngenxa yokuba i-Talarozole ineprofayili yokhuseleko eyamkelekileyo ebantwini, izazinzulu zinethemba elikhulu lendlela egudileyo yokusetyenziswa kwezonyango. Baqhube olunye uphando oluncinci lobungqina bombono ukubona ukuba ezi ziphumo zokuqala zingaphinda ziphindwe, babeka isiseko sendlela yonyango entsha kwi-OA.

iithagethi zebhayoloji

Kwakhona, uGqr. Essar-Brown wongezelela wathi, “Kukho imfuneko engxamisekileyo yonyango lokuguqula izifo ezenzelwe ukuthintela okanye ukubuyisela umva iimpawu ezibuhlungu ze-rheumatoid arthritis. Olu pho nonongo lubonisa ukuqonda okutsha kwezizathu ze-osteoarthritis yesandla, enokuthi iholele ekuchongeni iinjongo ezintsha zezinto eziphilayo zokungenelela ekufikeleleni kwe-OA. "