Ingaba umntu usesichengeni sosulelo lwe-COVID-19?

Ingaba umntu usesichengeni sosulelo lwe-COVID-19?

Njengoko izifundo ziqhubeka nokutyhila indlela yokuziphatha kwentsholongwane kaCorona, ethe yaliphazamisa ilizwe phantse iminyaka emibini, izazinzulu kwiYunivesithi yaseGlasgow yeZiko loPhando lweNtsholongwane eSkotlani zichonge uhlobo lofuzo oluchaphazela indlela umntu anokunyamezela ngayo usulelo lwe-Covid-19. .

Kwangelo xesha, abaphandi abaphononongo lwabo lwapapashwa kwijenali ethi "Isayensi" balumkisa ngomngcipheko wokuvela kweentlobo ezintsha zentsholongwane yeCorona, betyeshela ukhuseleko lwendalo olunikezelwa ngulo mfuza kwabanye abantu.

Uphononongo luphinde lwabonisa ukuba enye yeentlobo zeeprotheni eziveliswa emzimbeni usebenzisa i-"OAS1" gene iyakwazi ukuchonga ngokufanelekileyo intsholongwane ye-"SARS Cove 2", kunye nokuthintela inkambo enzima yesifo.

tshabalalisa iintsholongwane

I-OAS1 gene, eyaziwayo kwisayensi, iqalisa umjikelo weenkqubo ezenza i-ribonuclease L isebenze, i-enzyme etshabalalisa iintsholongwane eziye zangena kwiseli kwaye ivuselela iimpendulo ze-immune ukulwa nosulelo.

Nangona kunjalo, ababhali bophononongo babonisa ukuba ngokwe "imiyalelo" equlethwe kwi "OAS1", enye yeendlela ezimbini ezilinganayo zeprotheyini eziqaphela iintsholongwane kwaye zibangele impendulo yokuzivikela komzimba inokuveliswa, emfutshane "p42" okanye "p46" ende, kwaye kuphela kokugqibela okusebenzayo ngokuchasene ne-coronavirus.. Eyabangela ubhubhane, apho iqela elikhethekileyo leemolekyuli lidityaniswe kuyo, eliququzelela ukusebenzisana kweprotheyini kunye neenwebu zeseli (ezi zibizwa ngokuba ziiproteni ze-prenylated).

Kwakhona, uphando lubonise ukubaluleka kokuqaphela ukuba i-pre-expression ye "OAS1" inxulunyaniswa nokukhusela kwiindlela ezinzima ze "Covid 19", kwaye oku kubonisa ukuba le ndlela yokuzivikela yomzimba isebenza njengenxalenye ebalulekileyo yempendulo yokukhusela i-antiviral.

E-Afrika naseYurophu

Ezi ziphumo zifunyenwe ngokusekwe kuphononongo lweegenomes zabantu abangama-499 abalaliswe esibhedlele benentsholongwane yeCorona, abangama-212 kubo, umzimba awuzange uvelise "p46", kwaye phakathi kweli qela, umngcipheko wokufa kunye nokwamkelwa kukhathalelo olunzulu. laliphezulu ngokuphindwe ngesiqingatha kunelinye iqela.

Baphinde bachaza ukuba ayinguye wonke umntu onohlobo olwahlukileyo olunoxanduva lokuvelisa i-isoform "p46", eqonda kakuhle izinto zentsholongwane ye-Corona, njengoko abaphandi bebonisa ukuba ixhaphake kakhulu phakathi kwabantu base-Afrika kunye nabaphambukeli abavela kweli lizwe. ilizwekazi kunayo nayiphi na enye indawo, kwaye bakhankanya ukuba Ngaphantsi eqhelekileyo phakathi kwabemi ikomkhulu Peru, Lima (11% amatyala), yaye ukuya kumlinganiselo omkhulu phakathi abameli Ishan abantu Nigeria (70% yamatyala). Ngelixa abaseYurophu bekwindawo yesibini.

Izazinzulu zinombono wokuba ukuba sesichengeni kwabemi abaninzi kwi-Covid-1 kunokuxhomekeka ngokuthe ngqo ekuxhaphakeni kokwahluka “okufanelekileyo” kwe-OASXNUMX kubemi.

gimmick kunye nokusasazeka ngokukhawuleza

Njengoko unjingalwazi uSam Wilson, intloko yeZiko loPhando lweNtsholongwane yaseGlasgow, egxininisa, kunokwenzeka ukuba intsholongwane ye-Covid-19 iya kufunda ixesha elide ukudlula le ndlela yokuzikhusela, engazange ihlangane nayo ngaphambili. Ufuzo lwe-OAS1 alukho kubathwali abaphambili be-"SARS-Cove-2", amalulwane ehashe.

Kwaye ijelo likamabonwakude laseBhritane "ITV" licaphule uWilson esithi uphando "lubonise ukuba i-coronavirus eyabangela ukuqhambuka kwe-SARS ngo-2003 yafunda ukuhlala kude ne-OAS1, iphawula ukuba utshintsho olutsha oluvela kwi-"SARS-Cove-2" ukuba ukwazile. Ukuqonda Eli cebo linokuba nako ukosuleleka kwaye liya kusasazeka ngokulula phakathi kwabantu abangagonywanga, nto leyo ethe yabona imfuneko yokubekwa esweni okuthe gqolo kotshintsho olusanda kuvela lwe-“SARS-Cove-2”.

Uqhubana njani nomntu ongakuhoyiyo ngobukrelekrele?

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