Ngaba iinanobodies iya kuba sisisombululo kwiCorona?

Kuvavanyo lokuqala lwee-nanobodies ezifana ne-monoclonal antibodies, kodwa zincinci, zizinzile kwaye zinexabiso eliphantsi ukuvelisa, abaphandi abavela kwiYunivesithi yaseMelika yasePittsburgh School of Medicine babonise ukuba iinanobodies eziphefumlayo ezijolise kwiprotein "ye-spike" ye-coronavirus evelayo, inokuba Ukuthintela kunye nokunyanga isifo esiqatha.

Kwiinkcukacha zophononongo olupapashwe kwijenali ethi "Inkqubela phambili yeSayensi", kwaye iqhutywe kwi-hamsters, abaphandi babonise ukuba iidosi eziphantsi ze-aerobic nanobody ebizwa ngokuba yi-Nanobody - 21 "PiN - 21", enokuthi ifakwe ikhusela i-hamsters kubunzima obunzima. ilahleko idla ngokunxulunyaniswa nosulelo oluqatha lwentsholongwane kwaye yehlisa inani lamasuntswana entsholongwane eyosulelayo kwimingxuma yeempumlo, umqala kunye nemiphunga ngesigidi amaxesha, xa kuthelekiswa nonyango lwe-placebo olusebenzisa i-nanobody engatshitshisi isiphumo sentsholongwane.

Wachaza ukuba ngokusebenzisa unyango lokuphefumla olunokuthi lunikezelwe ngokuthe ngqo kwindawo yosulelo kwindlela yokuphefumla kunye nemiphunga, sinokwenza unyango lusebenze ngakumbi, lubonisa ukuba ithemba likhulu, ngakumbi emva kokuba i-nanobody (PiN - 21) iqinisekisile ukuba. inokukhusela kakhulu kwizifo ezinobuzaza, kwaye inokuba Ikhusela ukosulelwa kwentsholongwane ukusuka komnye umntu ukuya komnye.

Isitofu sokugonya sesona sisombululo

Iingcali zenzululwazi kwafuneka zinqobe imingeni emininzi yezobugcisa kolu phando, njengoko i-nanoparticles kufuneka ifikelele nzulu kwimiphunga, kwaye iinqununu zonyango kufuneka zibe zincinci ngokwaneleyo ukuze zingadibanisi kunye kwaye zomelele ngokwaneleyo ukumelana noxinzelelo olunzima.

I-PiN-21 nanobodies, emalunga namaxesha ama-4 amancinci kunee-antibodies eziqhelekileyo ze-monoclonal ezinozinzo oluphezulu olukhethekileyo, ziwufanelekele lo msebenzi, zixabiso eliphantsi kakhulu ukuvelisa, kwaye zinokuveliswa ngokukhawuleza ukuba zilungelelanise ngokukhawuleza kwintsholongwane yokutshintsha imilo.

Ukongezelela, abaphandi babonise ukuba i-nanobodies kunye nezitofu zokugonya ziyancedisana kwaye azikhuphisani, kwaye izitofu zihlala ziyiyona ndlela yokuthintela ukusasazeka kwentsholongwane ukusuka komnye umntu ukuya komnye.

Uye wachaza ukuba i-nanobodies iya kuba luncedo kuphela ekunyangeni abantu abasele begula nabangakwaziyo ukugonywa kwezinye izizathu zonyango.

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