Izindaba ezimbi ezivela kuCorona kulabo abakhuluphele

Emininingwaneni, uDokotela Jesus Eugenio Sosa Garcia, obhekele amacala abucayi egunjini labagula kakhulu esibhedlela iMedica Sur eMexico City, ukuqinisekisile ukuthi into egqame kakhulu kuwo wonke amacala asengozini enkulu ye-Covid-19 abelapha. bekukhuluphala.

Wengeze, ngokwephephabhuku lezokwelapha i-Nature, ukuthi yena nozakwabo bahlola izibalo ekuqaleni kwalolu bhubhane futhi bathola ukuthi ingxenye yeziguli ezingu-32 ezilaliswe egunjini labagula kakhulu yayikhuluphele.

Naphezu kokuba nethemba lokuthi umuthi wokugomela igciwane elisafufusa uzokhiqizwa maduze, kodwa eMexico nakwamanye amazwe amaningi anenani elandayo labantu abanezinkomba zesisindo somzimba ophezulu (BMIs), abanye abacwaningi besaba ukuthi lo mgomo ungase ungabi i-panacea odokotela futhi iziguli zinethemba.Zombili

Umthombo omusha ongalindelekile wokudluliselwa kwe-corona

Ukuhlolwa komtholampilo

E-United States, uDonna Ryan, ocwaninga ngokukhuluphala ngokweqile e-Pennington Biomedical Research Center eBaton Rouge, eLouisiana, uthi: “Kuyasikhathaza lokho.” Imithi yokugoma, ewusizo kwezinye izimo ezimbalwa, ngokuvamile ayisebenzi. Lokhu kuphakamisa ukuthi umuthi wokugomela i-COVID-19 ungase unganikezi isivikelo esiningi njengoba bekulindelwe.

Nakuba abacwaningi abakwazanga ukuqiniseka ukuthi ukukhuluphala kungaba nomthelela ekusebenzeni komgomo, kungenzeka ukuthi kutholakale ezinye izindlela zokubhekana nezinkinga uma zivela. Kepha ososayensi baphinde bazwakalisa ukukhathazeka ngokuthi izivivinyo zomtholampilo kungenzeka zingakwazi ukubona izinkinga ezinjalo ngokushesha noma ezigabeni zokuqala.

Izingozi zikhula njalo

Futhi eChina, kwacaca ekuqaleni kokuqubuka kwesifo i-Covid-19 ukuthi ukukhuluphala kwandisa ingozi yokutheleleka, lapho udokotela wezifo eziwumshayabhuqe uLin Shu eSun Yat-Sen University eGuangzhou ehlaziya imininingwane yegagasi lokuqala lalolu bhubhane ezweni. ezweni, wabona ukuvela kwephethini kumodeli Ngamunye, uphakamisa ukuthi i-BMI ibilokhu iyisici esicacile ebunzimeni bamacala e-COVID-19.

Izizathu ezingenzeka

Lapho ehambisa isifundo sakhe kujenali yezemfundo ngoMashi 2020, abahleli abaphethe lo magazini bamnxusa ukuthi axhumane nezikhulu ze-WHO futhi azitshele ngalokho akutholile.

Kusukela lapho, kuye kwavela imiphumela yocwaningo lwesayensi emhlabeni wonke, olufinyelele esiphethweni esifanayo, sokuthi labo abakhuluphele maningi amathuba okuthi bafe uma benesifo se-Covid-19 uma kuqhathaniswa nalabo abanesisindo esijwayelekile, ngisho nasesikhumbeni. ubukhona bezinto ezifana nesifo sikashukela kanye nokubhekelela umfutho wegazi ophezulu.

izicubu ze-adipose

Ngaphezu kwalokho, ukukhuluphala kungabhebhethekisa imiphumela ye-metabolic yokutheleleka nge-coronavirus. Izicubu ze-adipose ziveza amazinga aphezulu kakhulu e-ACE2 (i-angiotensin-converting enzyme 2) esetshenziswa yi-coronavirus ukuhlasela amaseli. "Izicubu ze-adipose zibonakala zisebenza njengechibi [le-coronavirus yenoveli]," kusho uDkt. Gianluca Iacobilis, isazi se-endocrinologist e-University of Miami eFlorida.

ukuvuvukala okungapheli

Kodwa yimiphumela yamasosha omzimba ebakhathaza kakhulu abanye abacwaningi, ngoba ukukhuluphala ngokweqile kungabangela ukuvuvukala okungapheli okusezingeni eliphansi, okucatshangwa ukuthi kunomthelela ekwandeni kwengozi yezimo ezifana nesifo sikashukela nesifo senhliziyo. Ngenxa yalokhu, abacwaningi basikisela ukuthi abantu abakhuluphele bangase babe namazinga aphezulu ezinhlobonhlobo zamaprotheni alawula amasosha omzimba, okuhlanganisa nama-cytokines.

Izimpendulo zamasosha omzimba ezikhishwe ama-cytokines zingalimaza izicubu ezinempilo kwezinye izimo ezinzima ze-COVID-19, kusho uMilena Sokolowska, ofunda nge-immunology kanye nezifo zokuphefumula e-University of Zurich eSwitzerland. Ngokuxakayo, uDkt. Sokolowska uyachaza, isimo esiqhubekayo sokugqugquzelwa kwamasosha omzimba, noma ukukhathala okuqhubekayo, kungase kukhinyabeze ezinye izimpendulo zokuzivikela komzimba, kuhlanganise nokusabela kwe-T-cell okungabulala ngokuqondile amangqamuzana angenwe yileli gciwane.

isikhathi eside

Ubufakazi bokuqala buveza ukuthi ukutheleleka kwe-SARS-CoV-2 kuqhubeka izinsuku ezinhlanu ezigulini ezikhuluphele kunalezo ezizacile, kusho uDaniel Drucker, udokotela we-endocrinologist nodokotela esibhedlela saseMount Sinai eToronto eCanada.

ama-microorganisms amathumbu namaphaphu

Ngenkathi u-Sokolowska engeza ukuthi ukukhuluphala kuholela emaqenjini aphansi futhi ahlukahlukene amagciwane emathunjini, ekhaleni nasemaphashini, kanye nezinkinga zemisebenzi ye-metabolic uma kuqhathaniswa nabantu abathambile. Uchaza ukuthi amagciwane amathumbu angathinta ukusabela kwamasosha omzimba ukumelana namagciwane noma ukusetshenziswa komzimba kwemithi yokugoma, ecaphuna kulo mongo lokho abacwaningi abamemezele, ngonyaka owedlule, ngokwesibonelo, ukuthi izinguquko ku-gut microbiome ngenxa yokuthatha ama-antibiotics kuthinta kabi Amasosha omzimba.Ukusabela komzimba emuthini wokugomela umkhuhlane.

I-13% yabantu abadala emhlabeni

Ngokwemininingwane yakamuva ye-World Health Organisation, cishe u-13% wabantu abadala emhlabeni bakhuluphele. USolwazi Ryan ukhomba ucwaningo lwemithi yokugomela umkhuhlane, isifo sokusha kwesibindi kohlobo B kanye namarabi, olubonise ukusabela okuphansi kulabo abakhuluphele kunalabo abanciphile. USolwazi Shaw uthi: "Ezimeni zokugomela umkhuhlane, awuzange uzuze imiphumela emihle ezigulini ezikhuluphele."

Ukwandisa imithamo

Kungenzeka ukuthi kutholakale izindlela zokunxephezela ukushiyeka komphumela wemithi yokugoma ezigulini ezikhuluphele, njengoba kwenzeka ngempumelelo yemizamo yabacwaningi yokuthuthukisa amazinga okusabela komgomo kubantu asebekhulile. USolwazi Ryan uthi ukunika abantu abakhuluphele imithamo eyengeziwe yomgomo yinto eyodwa engenzeka. "Mhlawumbe amashothi amathathu esikhundleni sokubili, noma umthamo omkhulu, kodwa odokotela akufanele bazibambe bethi umuthi wokugoma ngeke usebenze."

Isililo sesexwayiso

Ekugcineni, u-Drucker waphawula, umhlaba ungase udinge ukulinda idatha evela ezifundweni zomtholampilo ukuze ucacise umgwaqo, kodwa ukulinda kungase kubangele izinzwa. UDkt. Sosa Garcia nabanye banethemba lokuthi ukuhlangana phakathi kwe-COVID-19 nokukhuluphala kungase kuphoqe abanye ohulumeni nezinhlelo zokunakekelwa kwezempilo ukuthi babhekane nezinkinga ezikhulayo zokukhuluphala ngokweqile emazweni abo, bethi: “Ukube ubuyisikhulu sezempilo yomphakathi futhi waqaphela ukuthi angama-40 I-% yabantu isengozini enkulu, Le datha iwucingo lokuvuka.”