Ungazithola kanjani izinzuzo zemidlalo ngendlela efanele?

Ungazithola kanjani izinzuzo zemidlalo ngendlela efanele?

Abacwaningi baseBaylor naseStanford Colleges of Medicine kanye nezikhungo zabo ezisebenzisana nabo babika embikweni oshicilelwe ku-Nature "Bakwazi ukuhlonza i-molecule egazini elikhiqizwa ngesikhathi sokuzivocavoca futhi linganciphisa ngempumelelo ukudla nokukhuluphala kumagundane.

Ngokusho kwe-Neuroscience News, okutholakele okusha kungaba nomthelela ekuthuthukiseni ukuqonda kososayensi ngezinqubo zomzimba eziyisisekelo sokusebenzisana phakathi kokuzivocavoca nokunciphisa indlala.

ukunciphisa ukukhuluphala

"Ukuzivocavoca okuvamile kuye kwaboniswa ukusiza ukunciphisa umzimba, ukulawula ukudla nokuthuthukisa iphrofayili ye-metabolic, ikakhulukazi kubantu abakhuluphele nabakhuluphele ngokweqile," kusho umlobi ocwaningayo uDkt. Yong Shu, uprofesa wezifo zezingane, umsoco kanye ne-molecular biology eBaylor College.

"Uma thina (abacwaningi) singaqonda indlela ukuzivocavoca okuholela ngayo kulezi zinzuzo, siseduze nokusiza abantu abaningi ukuba bathuthukise impilo yabo," engeza.

"Ukuqonda ukuthi ukuvivinya umzimba kusebenza kanjani ezingeni lamangqamuzana kuzosivumela ukuthi sikwazi ukuvuna ezinye zezinzuzo zako," kusho umlobi-mbhali uProfesa Jonathan Long, uprofesa osizayo we-pathology e-Stanford Medicine kanye nomcwaningi e-Stanford Chem-H Institute.

Abadala nababuthaka

“Isibonelo, abantu asebekhulile noma ababuthaka abangakwazi ukuvivinya umzimba ngokwanele ngolunye usuku bangase bazuze ngokuthatha umuthi ongasiza ekunciphiseni ukukhumuzeka kwamathambo, isifo senhliziyo, noma ezinye izimo,” wanezela.

Ama-amino acid

U-Xu, Long kanye nozakwabo benze ukuhlaziya okuphelele kwezinhlanganisela ze-plasma yegazi ezithathwe kumagundane ngemva kokugijima kakhulu kumshini wokunyathelisa. I-molecule enamandla kakhulu kwakuyi-amino acid eguquliwe ebizwa ngokuthi i-Lac-Phe. Yenziwe nge-lactate, okuwumphumela wokuzivivinya kanzima, okubangela ukuzwa "okuvuthayo" emisipha, kanye ne-phenylalanine, i-amino acid engenye yezakhi zamaprotheni.

ukubekezelelwa kweglucose

Amagundane akhuluphele anikezwe ukudla okunamafutha aphezulu ehlise ukudla okudliwayo cishe ngo-50% uma kuqhathaniswa nokulawula amagundane esikhathini esingamahora angu-12, ngaphandle kokuphazamisa ukunyakaza kwawo noma ukusetshenziswa kwamandla. Lapho inikezwa amagundane izinsuku ezingu-10, i-Lac-Phe yehlisa ukudla okuqoqiwe kanye nesisindo somzimba (ngenxa yokuncipha kwamafutha omzimba) kanye nokubekezelela ushukela okuthuthukisiwe.

Ukuntuleka kwe-enzyme ye-CNDP2

Abacwaningi baphinde bathola ukuthi i-enzyme ebizwa ngokuthi i-CNDP2 ihileleke ekukhiqizeni i-Lac-Phe nokuthi amagundane angenalutho kule enzyme awazange alahlekelwe isisindo esiningi embusweni wokuzivocavoca njengoba enza neqembu lokulawula ohlelweni olufanayo lokuzivocavoca.

Ukwanda okumangalisayo

Kuyathakazelisa ukuthi ithimba labacwaningi liphinde lathola ukuphakama okuqinile emazingeni e-plasma e-Lac-Phe ngemva kokusebenza ngokomzimba kumahhashi omjaho nakubantu. Idatha evela eqenjini labantu abenza umsebenzi wokuvivinya umzimba njengokugijima ibonise ukuthi kube nokwanda okumangazayo kwamazinga e-Lac-Phe, okuvele ngemva kokugijima okulandelwa ukuqeqeshwa ukumelana nokuqeqeshwa kokukhuthazela.

"Izinyathelo zethu ezilandelayo (ithimba labacwaningi) zihlanganisa ukuthola imininingwane eyengeziwe mayelana nokuthi i-Lac-Phe ixhumanisa kanjani imiphumela yayo emzimbeni, kuhlanganise nobuchopho," kusho uDkt. Shaw. "Umgomo ukufunda ukuguqula indlela yokuzivocavoca ngezinjongo zokwelapha. "