Ucwaningo olusha lokwandisa inzalo yabesifazane

Ucwaningo olusha lokwandisa inzalo yabesifazane

Ukuzala kowesifazane kuvame ukwehla kusukela eminyakeni ephakathi kuka-30, okungenza kube nzima kakhulu ukuthola izingane eminyakeni ephakathi. Ithimba lososayensi lisanda kuthola indlela ebonakala isheshisa ukuguga kwama-ovari, futhi bathole indlela, okungenani kumagundane kuze kube manje, yokuyinciphisa ukuze ikhulise ukuzala kamuva ekuphileni, ngokusho kwe-New Atlas, icaphuna. iphephabhuku Nature Aging.

Ububi bokuzalanisa okwenziwa

Azikho izitho ezikhula ngezinga elifanayo, futhi ngeshwa ama-ovari angenye yezitho ezibhekana nalesi simo ngokushesha kakhulu, kodwa ososayensi abaqiniseki ngokuphelele ukuthi kungani. Kusukela eminyakeni engama-35, ama-ovari ayakhula ngokushesha, okuholela ekwehleni kwekhwalithi yamaqanda kanye nempumelelo ekukhulelweni. Iziguli eziningi ziphendukela ekufakweni kwembewu yokwenziwa, kodwa kuyindlela engase ibize futhi ilethe izingozi ezintsha.

CD38 gene

Ocwaningweni olusha, ososayensi baseNyuvesi yaseZhengzhou eChina baphenye izindlela zebhayoloji ezingaba yimbangela yalokhu kwehla. Bahlaziye amaphethini wokuvezwa kofuzo kumagundane amancane, cishe izinyanga ezimbili ubudala, namagundane aneminyaka ephakathi nendawo, cishe izinyanga eziyisishiyagalombili ubudala, kuma-ovari nezinye izitho.

Abacwaningi bathole ukuthi kumagundane amadala, ukuvezwa kofuzo olubizwa nge-CD38 kwanda, ikakhulukazi kuma-ovari. Lokhu akuzange kumangaze ngokuphelele, njengoba i-CD38 iwuphawu lokuguga olwaziwayo, ngoba ikhiqiza i-enzyme ephula iphrotheni ebizwa nge-NAD+, kamuva eyatholwa emazingeni aphansi kakhulu kumagundane asebekhulile.

Ikhwalithi yamaseli namaqanda

Iphrotheni ye-NAD, kanye nefomu layo elenziwe nge-oxidized i-NAD+, ilawula i-cell metabolism kanye nokulungiswa kwe-DNA, futhi yehla ngokwemvelo ngokukhula. Amazinga aphezulu ahlotshaniswa nempilo ende kanye nempilo engcono njengeminyaka eyodwa, ngakho-ke sekugxilwe kucwaningo lwesimanje lokulwa nokuguga, olunemiphumela ethile ethembisayo. Manje kubonakala sengathi lesi sizathu esivamile futhi siyimbangela yokuncipha kokuzala okuhlobene neminyaka.

"Lokhu kuncipha kwe- [NAD+] kumelela uchungechunge lwemiphumela emibi, ikakhulukazi ethinta ikhwalithi yawo womabili amaseli e-somatic namaqanda, ngaleyo ndlela kube nethonya elikhulu ekuzaleni kwabesifazane," kusho u-Qingling Yang, umcwaningi ocwaningweni olusha.

Ucwaningo ngamagundane

Ekuhloleni kokulandelela, ithimba lisuse isakhi sofuzo se-CD38 kumagundane amadala - futhi ngokuqinisekile, imiphumela yaba amaqanda ekhwalithi ephezulu kakhulu. Abacwaningi babe sebeqala ukuhlola ukuze babone ukuthi ingabe umphumela ofanayo ungafinyelelwa ngaphandle kobunjiniyela bofuzo, ukuze bakwenze kube ukwelashwa okunokwenzeka kakhudlwana kokuzala.

ukuhlolwa kwemitholampilo

Ngaphezu kwalokho, abacwaningi baphendukela ku-molecule ebizwa ngokuthi i-78c, evimbela i-CD38, futhi yanikezwa amagundane aselabhorethri anezinyanga eziyisishiyagalombili ngokwemvelo. Impela, amazinga e-NAD+ anda kuma-ovari, futhi amagundane akwazi ukuzala amanye.

Izivivinyo zemitholampilo okwamanje ziyenziwa ukuze kubonakale ukuthi ukukhulisa amazinga e-NAD+ kwabesifazane abathola ukwelashwa okusizwayo kokuzala kungathuthukisa amanani empumelelo futhi kunciphise nengozi yokukhubazeka kokuzalwa.

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