Nazi izindlela ezibaluleke kakhulu zokuvimbela inyumoniya

Nazi izindlela ezibaluleke kakhulu zokuvimbela inyumoniya

I-Zinc itholwe ibalulekile ekuvimbeleni izifo zamaphaphu kubantu abane-cystic fibrosis, amandla abo emvelo amasosha omzimba okulwa namagciwane ancishisiwe ngenxa yokuguqulwa kofuzo okubangela lesi sifo. , kunciphisa ukuvuvukala..

Inkomba yokufa ngaphambi kwesikhathi

Ngokusho kwewebhusayithi ye-New Atlas, icaphuna iphephabhuku le-PNAS, eminyakeni engama-25 edlule, i-cystic fibrosis yayiwuphawu lokungenzeka usheshe ufe, kanti nakuba isikhathi sokuphila sithuthuke kakhulu kusukela ngaleso sikhathi, abantu abane-cystic fibrosis basesengozini yezinkinga eziba umphumela. icala.

Ukuguqulwa kofuzo ku-cystic fibrosis transmembrane conductance regulator (CFTR) kubangela ukunqwabelana ngokweqile kwamafinyila emaphashini kanye nokuvuvukala komzila womoya okungahlelekile, okwenza abantu abanalesi simo babe sengozini yokuthola izifo eziphindelelayo. Kepha abacwaningi baseNyuvesi yaseQueensland e-Australia baphumelele ukuthola indlela engaba khona yokunciphisa izifo kubantu abane-cystic fibrosis, ethembele ku-zinc.

Ukumelana nama-antibiotic

"Abantu abane-cystic fibrosis banesimo sokuvuvukala kakhulu emigwaqweni yabo yomoya futhi basengozini yokuthola izifo ezibangelwa amagciwane, kodwa ukwelashwa okuphindaphindiwe ngama-antibiotic kungase kuholele ezifweni ezimelana nemithi elwa namagciwane," kusho uPeter Sly, MD, udokotela wezingane zokuphefumula kanye nokucwaninga ngokubambisana umbhali. Vitality.”

Ukwelashwa kwamanje

"Ukwelashwa kwamanje kungabuyisela izici eziningi zomsebenzi we-CFTR, kodwa azixazululi noma zivimbele izifo zamaphaphu, ngakho-ke kunesidingo sokubuyisela ukusebenza kokuzivikela komzimba," kusho uDkt Sly.

Ngokutadisha ukuthi ukuguqulwa kwe-CFTR kulithinta kanjani ikhono lamangqamuzana omzimba omzimba, abizwa ngokuthi ama-macrophages, ukulwa namagciwane, abacwaningi banqume ukuthi ku-cystic fibrosis, ama-macrophages wamaphaphu awakwazi ukusebenzisa kahle i-zinc njenge-ejenti elwa namagciwane.

Amazinga anobuthi

UMat Sweet, umcwaningi okanye naye kulolu cwaningo, wathi: “Enye yezindlela amangqamuzana e-phagocytic abhubhisa ngayo amagciwane iwukuwafaka ubuthi ngezinsimbi ezinobuthi njenge-zinc,” ephawula ukuthi “umzila we-ion we-CFTR ubalulekile ku-zinc. indlela, nangenxa yokuthi ayisebenzi kahle kubantu abanaleli gciwane.” “Nge-cystic fibrosis, ngokwengxenye ingase ichaze ukuthi kungani bengenwa kalula izifo ezibangelwa amagciwane.”

Ukungasebenzi

Ngaphezu kokuhlonza ukungasebenzi kahle kwe-zinc emangqamuzaneni, abacwaningi baphinde bathola iphrotheni yokuthutha i-zinc, i-SLC30A1, ebuyisele amandla ama-macrophage okubulala amagciwane esimweni soguquko lwe-CFTR, okusho ukuthi ukwelashwa kwe-zinc okungeziwe bekwanele ukubuyisela ukubulawa kwamagciwane ama-macrophages wamaphaphu womuntu ku-vitro.

Isu elisha

Imiphumela iphakamisa ukuthi ukubuyisela impendulo kubuthi be-zinc kungase kulandelwe njengesu lokwelapha lokubuyisela ukusebenza komzimba kanye nokuzivikela okuphumelelayo kubantu abane-cystic fibrosis, umcwaningi u-Sweet echaza ukuthi umgomo okwamanje "ukuletha iphrotheni yokuthutha i-zinc kuma-macrophages kubantu. nge-cystic fibrosis ngokulindela ukuthi izovuselela ukusabela kwayo kwamasosha omzimba.” “Yehlisa ukutheleleka.”

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