I-China ihlinzeka ngokuvikeleka kwangaphambili ngokumelene nokwahluka okusha kwe-Corona

I-China ihlinzeka ngokuvikeleka kwangaphambili ngokumelene nokwahluka okusha kwe-Corona

Abacwaningi baseShayina benze umuthi wokugomela impushana osetshenziswa njengomthamo owodwa ngokuhogela ngqo emaphashini ukuze ukhiqize impendulo ephumelelayo yokuzivikela komzimba. Umuthi wokugoma ungaveza ama-antigen amaningi, okusho ukuthi umthamo owodwa unganikeza ukuvikeleka okubanzi kumagciwane amaningi okuphefumula, ngokwalokho okushicilelwe iwebhusayithi ye-New Atlas, ecaphuna iphephabhuku le-Nature.

Umthelela omncane ekudluliselweni kwegciwane

Ukufika kobhubhane lwe-COVID-19 kuholele ekuthuthukisweni kwezobuchwepheshe bokugoma, okubandakanya imigomo eyaziwa manje ye-mRNA, eminingi yayo enikezwa ngomjovo engalweni noma emsipha, ikhiqize ukuzivikela okuhlekisayo, okungukuthi okubandakanya uketshezi lomzimba nokuthembela kumasosha omzimba nciphisa igciwane kodwa hhayi ukuzivikela komzimba. Yize imijovo yokugomela i-SARS-CoV-2 ikhonjiswe ukuthi yehlisa kakhulu izinga lokugula nokufa, inomthelela omncane emazingeni okudluliselwa kwaleli gciwane.

Ukulawula ukutheleleka kusenesikhathi

Ukukhiqiza impendulo yokuzivikela ezicutshini ze-mucosal yomzila womoya kubalulekile ekulawuleni ukutheleleka kusenesikhathi futhi kungakhiqiza ukuzivikela okuqinile nokuhlala isikhathi eside ngezimpendulo zokukhumbula ngokushesha. Ukuze kubhekwane nezinkinga ezihambisana nemithi yokugoma ejovwayo, abacwaningi abavela ku-Institute of Process Engineering ye-Chinese Academy of Sciences basungule umuthi wokugoma wempushana owomile onedosi elilodwa.

Ama-Microspheres nama-nanoparticles

Inkundla yokugoma emisha ihlanganisa ama-microspheres abolayo nama-protein nanoparticles, indawo engaphezulu engabonisa ama-antigen amaningi, izinto ezenza amasosha omzimba akhiqize amasosha omzimba. Ukuba khona kwama-antigen angaphezu kweyodwa kunweba ububanzi bokuvikela amagciwane okunikezwa umgomo futhi kubangela impendulo ebanzi yokuzivikela komzimba. Isibonelo, ingafaka ama-antigen avela ezinhlobonhlobo ze-SARS-CoV-2 noma i-SARS-CoV-2 ngokuhlangana nomunye umuthi wokugomela igciwane lokuphefumula.

Ukungavikeleki kwe-Humoral kanye namaselula

Lapho ama-antigen nanoparticles esekhululiwe, amaphaphu angawamunca ngokuphumelelayo. Ngenxa yokuthi ama-nanoparticles akhululwa ngokuqhubekayo, ahlinzeka ngokuzivikela okuhlala isikhathi eside kwe-humoral, amaselula kanye ne-mucosal ngomthamo owodwa wokuhogela. Abacwaningi bahlole umgomo wabo oyimpushana kumagundane, ezilwaneni zaselabhorethri, nasezifundweni ezingezona ezomuntu, futhi babona ukukhiqizwa okuqinile kwe-antibody kanye nokusabela kwe-T-cell yendawo, okubonisa ukuvikelwa kwegciwane okusebenzayo.

Ukuhumusha komtholampilo kuyeza maduze

"Izingxenye zale nanosystem encane zisebenzisa amaprotheni emvelo nezinto ezivunyiwe ze-polymeric, futhi ukusebenza kahle nokuphepha komgomo kuye kwacwaningwa ngokuhlelekile kuma-primates okungezona abantu, okubonisa amandla ayo amakhulu okuhunyushwa komtholampilo," kusho u-Wei Wei, omunye wabacwaningi. esifundweni.

Ngokombono wokukhiqiza, iqiniso lokuthi umuthi wokugoma uyimpushana eyomile kusho ukuthi awudingi isiqandisi, okunciphisa kakhulu izindleko zokulondoloza nezokuthutha futhi kwenze kube lula ukusetshenziswa ezindaweni ezingenazo noma ezilinganiselwe izinsiza zokuqandisa.

Izibikezelo zothando ze-Scorpio zonyaka ka-2024