Ucwaningo olusha noluthembisayo lokwelapha iziguli zenhliziyo

Ucwaningo olusha noluthembisayo lokwelapha iziguli zenhliziyo

Abacwaningi base-Australia baye bafinyelela imigomo emibili yokuqala ezosiza umzamo womhlaba wonke wokulwa nesifo senhliziyo: okungukuthi, ukwenza ukushaya kwenhliziyo encane ngesistimu yayo ye-vascular, futhi okwesibili ukuthola ukuthi uhlelo lwe-vascular luthinta kanjani ukulimala kwenhliziyo okubangelwa ukuvuvukala.

Izigidi zokufa minyaka yonke

Ngokwe-website ye-“New Atlas”, icaphuna iphephabhuku elithi “Cell Reports”, izifo zenhliziyo nemithambo yegazi ziphakathi kwezimbangela ezihamba phambili zokufa emhlabeni wonke.” Ngokwe-World Health Organization “WHO”, izifo zenhliziyo nemithambo yegazi zibulala abantu abalinganiselwa ezigidini ezingu-17.9 ngonyaka. Izifo zenhliziyo nemithambo yegazi kulindeleke ukuthi zikhuphuke, uma kubhekwa ukuguga kwabantu kanye nomthelela wezinto eziyingozi empilweni.

Isifo senhliziyo

Isifo senhliziyo nemithambo yegazi sihlanganisa noma isiphi isimo esithinta inhliziyo noma ukujikeleza kwegazi, njengokuhlasela kwenhliziyo, isifo sokuqina kwemithambo yegazi, umfutho wegazi ophakeme, isifo sohlangothi, nokuwohloka komqondo kwemithambo. Uma kubhekwa ukusabalala kwe-CVD, kubalulekile ukuthi ucwaningo luqhubeke luveze izindlela ezintsha zokuvimbela kanye nokuwohloka komqondo. hlola leli qembu lezifo bese welaphe.

Izakhiwo ezincane ezilingisa inhliziyo

Abacwaningi base-Australia baye basheshisa ucwaningo emkhakheni wesifo senhliziyo ngokwenza ama-organelles, izakhiwo ezincane ezilingisa izitho zomuntu, ezikhule elabhorethri zisebenzisa amangqamuzana e-stem pluripotent womuntu, angadalwa kusetshenziswa isikhumba "esihlelwe kabusha" noma amaseli egazi.

UJames Hudson, omunye wabacwaningi kulolu cwaningo, wathi: 'I-organelle ngayinye yenhliziyo ilingana nembewu ye-chia, ububanzi obungamamilimitha angu-1.5 kuphela, kodwa ngaphakathi kwayo kunamangqamuzana angu-50000 XNUMX amelela izinhlobo ezahlukene zamangqamuzana akha inhliziyo. .

Kusukela eqenjini lama-organelles amancane, abacwaningi badala inhliziyo eshayayo.Isinyathelo ngokwaso asisona esisha, kodwa kungokokuqala ukuthi amangqamuzana e-vascular, amangqamuzana ahambisana nemithambo yegazi, angahlanganiswa ngempumelelo, alethe inhliziyo yemodeli eduze inhliziyo yomuntu yangempela.

U-Hudson uthe: “Ukufakwa kwamangqamuzana emithambo yegazi okokuqala ngqa emisipha yenhliziyo encane kubaluleke kakhulu ngoba kuye kwatholakala ukuthi kunendima ebalulekile kubhayoloji yezicubu, njengoba amangqamuzana emithambo yegazi enza ama-organelles asebenze kangcono futhi ashaye ngamandla, kulokho okusha. okokuqala lokho kuyosiza ekuqondeni inhliziyo kangcono.” ukufanisa ngokunembile isifo.

Kwengezwe ukutholwa

Ibhonasi eyengeziwe yamangqamuzana e-vascular isho ukuthi abacwaningi bangaphenya ukuthi kuthinta kanjani ukuvuvukala, okungabangela i-atherosclerosis nokuvuvukala kwemisipha yenhliziyo.Kolunye ucwaningo, abacwaningi baveze indima ebalulekile edlalwa uhlelo lwe-vascular ekulimazeni kwemisipha yenhliziyo okubangelwa ukuvuvukala.

Indima enkulu yamaseli emithambo yegazi

U-Hudson uthe, “Lapho ukuvuvukala kugqugquzelwa emisipheni emincane yenhliziyo, kwatholakala ukuthi amangqamuzana emithambo yegazi adlala indima enkulu,” njengoba kwavela ukuqina kwezicubu eziqukethe amangqamuzana emithambo kuphela, okusho ukuthi amangqamuzana ayezwa okwenzekayo. nokuthi amangqamuzana akhipha isici esibizwa ngokuthi i-endothelin esixhumanisa i-sclerosis.”

Abacwaningi bathi ukutholakala okwengeziwe, kuhlanganiswe nokusetshenziswa kwama-organoid enhliziyo amasha, kungaholela ekwelashweni okusha kwesifo senhliziyo ngokushesha okukhulu.

Izifo zezinso nobuchopho

Ukushicilela lolu cwaningo, abacwaningi bathi, kuzosiza abacwaningi emhlabeni wonke ukuthi bakhe ama-organoid emithanjeni yegazi, kukhuphule imizamo yomhlaba wonke yokubhekana nesifo senhliziyo.

Izibikezelo ze-horoscope zika-Maguy Farah zonyaka ka-2023