Funda nge-hormone ebangela ukusabalala komdlavuza egazini

Asikwazi ukubala izimbangela zomdlavuza, njengoba kuyisayensi yamakhemikhali okuhileleke kuyo izici eziyinkulungwane, kodwa ukuhlola kwamuva nje kwaseBrithani kwathola ukuthi i-hormone yokucindezeleka yomuntu noma “cortisol” iyisici esiyinhloko esibangela ukwehluleka kwesimiso somzimba sokuzivikela ezifweni ukuvimbela i-leukemia. .

Ucwaningo lwenziwe abacwaningi baseNyuvesi yaseKent, eBrithani, futhi bashicilela imiphumela yabo, kumagazini wakamuva wephephabhuku i-Cellular and Molecular Immunology.

Ithimba, eliholwa uDkt. Vadim Sumbaev, lathola okokuqala ukuthi amangqamuzana e-acute myeloid leukemia agwema amasosha omzimba ngokuqasha i-hormone yomuntu i-cortisol.

Ithimba, ocwaningo lwalo olugxile ezimbangela zalesi sifo, lathi i-leukemia isebenzisa indlela eyingqayizivele yokuthuthuka emzimbeni, isebenzisa izinhlelo zokusebenza zomzimba womuntu ukuze isekele ukusinda kwamangqamuzana, kanye nokunciphisa imisebenzi ye-anti immune anti. -umdlavuza.

Ucwaningo luphinde lwafakazela ukuthi i-leukemia isebenzisa i-hormone i-cortisol ukuphoqa umzimba ukuthi ukhiphe iphrotheni “latrophyllin 1”, okuholela ekukhiqizweni kwelinye iphrotheni elibizwa nge-“galectin 9” elicindezela amasosha omzimba emvelo alwa nomdlavuza.

Ithimba likaSumbayev, elisebenzisana nabacwaningi bamanyuvesi amabili aseJalimane, lithole ukuthi nakuba amangqamuzana amhlophe egazi anempilo engathinteki ngenxa ye-cortisol, ayakwazi ukukhulula iphrotheni i-latrophyllin-1 lapho umuntu eba ne-leukemia.

Ucwaningo luphethe ngokuthi i-galectin-9, kanye ne-latrophylin-1, okungamaprotheni amabili atholakala ku-plasma yegazi lomuntu, ayizinjongo ezithembisayo ze-immunotherapy ukulwa ne-acute myeloid leukemia esikhathini esizayo.

"Ngokokuqala ngqa, singakwazi ukukhomba indlela eyenza esikhathini esizayo sithuthukise ukwelashwa okusha okuphumelelayo sisebenzisa izindlela zokuzivikela zemvelo zomzimba ukulwa ne-leukemia," kusho u-Sumbaev.

I-acute myeloid leukemia yakha emnkantsheni futhi iholela ekwandeni kwenani lamaseli amhlophe egazi.

Ngokwezilinganiso ze-US National Cancer Institute, cishe izigameko ezingu-21 ze-acute myeloid leukemia zizotholakala kulo nyaka e-United States.