ICorona Entsha .. igciwane elikwazi ukulingisa, ukuxaka nezimangaliso

Esikhathini lapho umhlaba wonke usahlupheka ngaphansi kwegciwane leCorona, ochwepheshe bazama ukugijima isikhathi ukuze baxazulule impicabadala yesitha somuntu, esesithelele abantu abangaphezu kwezigidi ezingu-44, futhi sabulala abangaphezu kwesigidi, njengoba ibonakale esikhathini esingaphansi konyaka odlule okokuqala ngqa eChina.

Okusha namuhla kutholwe ucwaningo olwenziwa abacwaningi baseVagelos College of Physicians and Surgeons e-Columbia University, abathi amagciwane e-corona anekhono ekulingiseni amaprotheni omzimba womuntu abandakanyeka esifweni esibi se-Covid-19. Ucwaningo lushicilelwe kusizindalwazi sejenali Cell System.

Ubusika beCorona bumnyama futhi kulindelwe okubi kakhulu ..

Ngakolunye uhlangothi, u-Sagi Shapira, umsizi kaprofesa we-system biology e-Vagelos College of Physicians and Surgeons e-Columbia University, kanye nomcwaningi oholayo walolu cwaningo, kusho umbiko oshicilelwe ngoLwesibili kuwebhusayithi yenyuvesi: "Amagciwane asebenzisa ukulingisa ngesizathu esifanayo nezilwane, okuyinkohliso,” enezela: “Sasicabanga ukuthi ukuhlonza okufana namaProtein igciwane Kungasinika izinkomba zendlela amagciwane - okuhlanganisa ne-coronavirus yenoveli - abangela ngayo. ”

“Okungaphezu kwalokho ebesingakucabanga”

Esebenzisa amakhompiyutha amakhulu ukuze aseshe abalingisi begciwane esebenzisa isofthiwe efana nokubonwa kobuso kwe-7000D, u-Shapira nethimba lakhe labacwaningi baskena amagciwane angaphezu kuka-4000 kanye nababungazi abangaphezu kuka-6 ku-ecosystem yonke futhi bathola izehlakalo eziyizigidi ezingu-XNUMX zokulingisa amagciwane.

Ingane iveza impatho yecorona, ingabe izophela le nhlekelele?

Wabuye wachaza ukuthi “ukulingisa kuyisu elisakazeke kakhulu phakathi kwamagciwane kunalokho esasikucabanga.Kusetshenziswa yizo zonke izinhlobo zamagciwane, kungakhathaliseki ukuthi ubukhulu begciwane lesandulela ngculaza, ukuthi igciwane lizalana kanjani, noma ukuthi igciwane lithelela amabhaktheriya, izitshalo, noma ngabe igciwane lithelela ama-bacterium, izitshalo. izinambuzane noma abantu.”

“ihlakaniphe kakhulu”

Uqhube wathi, “Kodwa-ke, ezinye izinhlobo zamagciwane zisebenzisa ukulingisa kakhulu kunezinye. Nakuba ama-papillomavirus kanye nama-retroviruses engawasebenzisi kakhulu, sithole ukuthi ama-coronavirus ahlakaniphe ngokukhethekile, futhi sithole ukuthi alingisa amaprotheni angaphezu kuka-150, okuhlanganisa amaningi alawula ukujiya kwegazi, iqoqo lamaprotheni omzimba asiza ukukhomba amagciwane. Izifo okufanele zibhujiswe,” ephawula ukuthi: “Sasicabanga ukuthi ngokulingisa amasosha omzimba namaprotheni ajiyisa amahlule, ama-coronavirus angase agxilise lezi zimiso zibe esimweni sokusebenza ngokweqile futhi abangele izifo esizibona ezigulini ezinaleli gciwane.”

Kuyaphawuleka ukuthi ngesikhathi salolu bhubhane, kwacaca ukuthi iziguli eziningi ezine-Covid-19 zinenkinga ye-coagulation nokuthi ezinye zazo manje sezelashwa ngama-anticoagulants nezidakamizwa ezinciphisa ukusebenza kwezithasiselo.

Ephepheni elihlukile elishicilelwe ku-Nature Medicine, abacwaningi base-Columbia University bathola ubufakazi bokuthi ukungasebenzi kahle kwezakhi zofuzo zohlelo oluhambisanayo kanye nama-clotting amaprotheni kuhlotshaniswa nesifo esibi se-COVID-19. Uhlelo oluhambisanayo, oluyingxenye yamasosha omzimba athuthukisa ikhono lama-antibodies kanye ne-phagocyte ukususa amagciwane namaseli alimele entweni ephilayo. Bathole ukuthi abantu abanokonakala kwe-macular (okuhlotshaniswa nokusebenza kohlelo oluhambisanayo) maningi amathuba okuthi bafe ngenxa ye-COVID-19, ukuthi izakhi zofuzo ezihambisanayo nezokujiyisa zazisebenza kakhulu ezigulini ezinalesi sifo, nokuthi abantu abanoshintsho oluthile oluhambisanayo kanye nokujiyisa babenamandla. maningi amathuba okuba nalezi.Ufuzo esibhedlela ngenxa yalesi sifo futhi.

Ngaphezu kwalokho, uShapira ucabange ukuthi ukuphenya imisebenzi yamaprotheni egciwane kanye nokulingisa kukhombisa ukuthi ukufunda ngebhayoloji eyisisekelo yaleli gciwane kungaba yindlela yokuqonda ukuthi amagciwane asidala kanjani isifo nokuthi ubani ongase abe sengozini enkulu.

Kubikwa ukuthi selokhu leli phepha laqala ukuvela entwasahlobo yalo nyaka enguqulweni yokuqala, abanye abacwaningi bathole ukuxhumana phakathi kokuqina kwe-supplement kanye ne-Covid-19, futhi izivivinyo eziningi zomtholampilo zama-inhibitors zalolu hlelo seziqalisiwe.