Iwashi lebhayoloji

Isigqi se-Circadian siyinqubo yemvelo yangaphakathi elandela umjikelezo wamahora angu-24 olawula ukulala, ukugayeka kokudla, ukudla, ngisho nokungavikeleki komzimba.

Izinto ezifana nokukhanya kwangaphandle, ukudla ukudla okuvamile, nokuba nokuzivocavoca umzimba ndawonye kusiza ukugcina iwashi lebhayoloji lisebenza ngokuvumelana. Ngokuphambene, ukwenza izinto ezincane njengokuhlala isikhathi eside kakhulu kunokujwayelekile, noma ngisho nokudla ngesikhathi esihlukile kunokuvamile, kungaphazamisa "iwashi" lakho langaphakathi.

Impilo yengqondo kanye nomdlavuza

Ososayensi be-Institute of Applied Sciences yaseNyuvesi yaseNew York beluleka ngokuthi isigqi se-circadian kufanele sigcinwe ngendlela, njengoba ukuphazamiseka kwalo mjikelezo kuye kwaxhunyaniswa nenani lezinkinga zempilo, okuhlanganisa ukuphazamiseka kwengqondo, umdlavuza nesifo i-Alzheimer's.

Ucwaningo lubonisa ukuthi ezigulini ezinesifo i-Alzheimer's, ukuphazamiseka kwesigqi se-circadian ngokuvamile kubonakala njengezinguquko emikhubeni yokulala yesiguli eyenzeka kudala ngaphambi kokuba lesi sifo sibonakale ngokugcwele. Isimo siba sibi kakhulu ezigabeni zakamuva zesifo. Kodwa namanje akuqondakali ngokugcwele ukuthi ukuntula ubuthongo kubangela isifo i-Alzheimer, noma ukuthi kwenzeka ngenxa yalesi sifo.

ama-plaque ebuchosheni

Abacwaningi bahlale bethola isakhi esivamile ebuchosheni babantu abanesifo i-Alzheimer’s ukunqwabelana kwamaprotheni abizwa ngokuthi “i-beta-amyloid”, ajwayele ukunqwabelana ebuchosheni bakhe “ama-plaque” ebuchosheni. Ama-beta-amyloid plaques aphazamisa ukusebenza kwamangqamuzana obuchopho, okungase kubangele izinkinga zokuqonda, njengokulahlekelwa inkumbulo. Ebuchosheni obujwayelekile, iphrotheni iyahlanzwa ngezikhathi ezithile ngaphambi kokuba nethuba lokubangela izinkinga.

isigqi sebhayoloji ubusuku nemini

Imiphumela yocwaningo lwakamuva ibonise ukuthi amaseli anesibopho sokususa ama-beta-amyloid plaques nokugcina ubuchopho buphilile nawo alandela isigqi se-circadian samahora angama-24, okusho ukuthi uma isigqi se-circadian siphazamiseka, kungenza kube nzima kakhulu ukususa amangqamuzana oqweqwe oluyingozi oluhambisana nesifo i-Alzheimer's.

ama-macrophages

Ukuze lenze ucwaningo lwalo, ithimba labacwaningi lihlole ngokukhethekile ama-macrophage, abizwa nangokuthi ama-macrophage futhi ngokuvamile ajikeleza ezicutshini eziningi ezixhumeneyo emzimbeni, kuhlanganise nobuchopho. Ama-Macrophage ikakhulukazi adla amagciwane noma ngisho namaprotheni angakhiwe ngendlela efanele, angabhekwa njengosongo emzimbeni.

Ukuqonda ukuthi lawa maseli omzimba alandela isigqi se-circadian, abacwaningi basebenzisa ama-macrophages athathwe kumagundane futhi akhuliswe elabhorethri. Futhi lapho bephakela amaseli nge-beta-amyloid, bathola ukuthi ikhono lama-macrophage lokususa i-beta-amyloid lashintsha esikhathini esingamahora angama-24.

Amaprotheni "ama-proteoglycans"

Kuye kwaboniswa nokuthi amaprotheni athile angaphezulu kwama-macrophage, abizwa ngokuthi i-proteoglycans, anesigqi esifana nese-circadian usuku lonke. Kwavela ukuthi lapho inani lama-proteoglycans liphansi kakhulu, ikhono lokususa amaprotheni e-beta-amyloid laliphezulu kakhulu, okusho ukuthi lapho ama-macrophage ane-proteoglycans eningi, awazange akhiphe i-beta-amyloid. Abacwaningi baphinde bathola ukuthi lapho ama-phagocyte elahlekelwa isigqi sawo esivamile se-circadian, ayeka ukwenza umsebenzi wokulahla amaprotheni e-beta-amyloid njengenjwayelo.

amangqamuzana omzimba omzimba

Nakuba ucwaningo lwakamuva lusebenzise ama-macrophage avela emzimbeni wamagundane ngokuvamile hhayi asuka ebuchosheni ngokuqondile, imiphumela evela kwezinye izifundo ibonise ukuthi i-microglia - amangqamuzana omzimba omzimba wobuchopho (okuphinde kube uhlobo olulodwa lwe-macrophage ebuchosheni) - ane-Biological yansuku zonke. isigqi. Iwashi le-circadian lilawula yonke into ehlobene nomsebenzi nokwakheka kwe-microglia kanye nokusabela kwabo kwamasosha omzimba. Kungenzeka ukuthi izigqi ze-microglial circadian nazo zinesibopho sokulawula ukuxhumana kwe-neural - okungase kube nomthelela ekwandiseni izimpawu zesifo i-Alzheimer's, noma izinkinga zokulala ezingatholwa abantu abadala.

Imiphumela eminingi engqubuzanayo

Kodwa ezifundweni eziye zabheka izinto eziphilayo eziphelele (njengamagundane) kunokuba nje amangqamuzana, okutholwe ebudlelwaneni phakathi kwesifo i-Alzheimer's kanye nesigqi se-circadian kuye kwangqubuzana kakhulu, njengoba ngokuvamile behluleka ukuthatha zonke izinkinga ezitholakala kubantu abanesifo i-Alzheimer's, njengoba kunjalo Iphuzu liwukuthi izinhlelo ezithile kuphela noma amaprotheni angathinteka isifo i-Alzheimer's afundwayo, okuphakamisa ukuthi angeke anikeze ukumelela okunembile ngokuphelele kokuthi isifo se-Alzheimer senzeke kanjani kubantu.

Ukwanda kwesifo i-Alzheimer's

Ocwaningweni lwabantu abanesifo i-Alzheimer's, abacwaningi bathole ukuthi isigqi esibi se-circadian singasenza sibe sibi kakhulu isimo njengoba lesi sifo siqhubeka. Okunye okutholwe ocwaningweni kuphinde kwakhombisa ukuthi ukuphazamiseka kwesigqi se-circadian kuxhumene nezinkinga zokulala kanye nesifo i-Alzheimer's, kanye nobuchopho bungakwazi ukuhlanza ubuchopho (kuhlanganise ne-beta-amyloid), okungenzeka kube nomthelela omkhulu ezinkingeni zenkumbulo. Kodwa kunzima ukunquma ukuthi ingabe ukuphazamiseka kwesigqi sokujikeleza (kanye nezinkinga ezisibangelayo) kungenzeka kube umphumela wesifo i-Alzheimer's, noma uma bekuyingxenye yembangela yesifo.

Ukulala kwekhwalithi kuyadingeka

Uma kuphindwaphindwa kubantu, okutholwe ocwaningweni cishe kuzonikeza isinyathelo esiseduze nokuqonda enye yezindlela isigqi sokujikeleza sixhunyaniswa nesifo i-Alzheimer's. Ekugcineni, kuvunyelwana kabanzi ukuthi ukulala kubalulekile ezicini eziningi zempilo yomuntu, ngakho-ke ukuvikela isigqi se-circadian kubalulekile futhi kuyadingeka ukuze kugcinwe isimo esihle sengqondo, ingqondo, isimo sengqondo kanye nempilo yonke.