Izimangaliso zesayensi ekuphulukiseni amacala e-AIDS

Izimangaliso zesayensi ekuphulukiseni amacala e-AIDS

Owesilisa owaziwa ngokuthi "yisiguli sase-Düsseldorf" usephenduke umuntu wesithathu ukumenyezelwa ukuthi welaphe i-HIV ngenxa yokufakelwa umnkantsha obuye wasiza ukwelapha umdlavuza wegazi lakhe, ngokocwaningo lwangoMsombuluko.

Kuze kube manje, zimbili kuphela izehlakalo zokwelashwa kwe-HIV nomdlavuza ezirekhodiwe kumajenali ezesayensi ngesikhathi esisodwa, ezigulini ezimbili eBerlin naseLondon.

Isiguli esingaziwa esineminyaka engu-53 ubudala, imininingwane yaso yokwelashwa eyashicilelwa kujenali i-Nature Medicine, kwatholakala ukuthi sine-HIV ngo-2008 futhi, eminyakeni emithathu kamuva, saba ne-acute myeloid leukemia, uhlobo lomdlavuza wegazi olubeka engcupheni enkulu yokuphila. Impilo yesiguli, ngokusho kwe "Agence France Presse".

ama-stem cell

Ngo-2013, isiguli safakelwa umnkantsha kusetshenziswa ama-stem cells anikezwa umnikeli onoguquko olungavamile ku-CCR5 gene, okuvimbela ukungena kwe-HIV kumaseli.

Ngo-2018, isiguli sase-Dusseldorf sayeka ukwelapha i-HIV ngezidambisigciwane.

Ngemva kweminyaka emine, imiphumela yokuhlolwa kwe-HIV isiguli ebesikwenza ngezikhathi ezithile yabuya ingenayo.

Ucwaningo lubonise ukuthi "le mpumelelo imele icala lesithathu lokululama ku-HIV," kuphawula ukuthi ukululama kwesiguli saseDusseldorf kunikeza "ukuqonda okubalulekile okuthenjwa ukuthi kuzoba nomthelela ekuqondiseni amasu esikhathi esizayo ahlobene nokwelashwa."

"umgubho omkhulu"

"Ngiyaziqhenya ngethimba lodokotela abasezingeni lomhlaba abangelapha ngempumelelo i-HIV kanye ne-leukemia ngesikhathi esisodwa," kusho isitatimende sesiguli.

Ubuye wengeza ngokuthi, “Ngenze umgubho omkhulu ngesikhathi ngiqeda iminyaka eyishumi ngafakwa umnkantsha ngosuku lwezithandani, olungesonto eledlule,” esho nokuthi onikele “ubeyisivakashi esihlonishwayo” kulo mgubho.

Phambilini kwamenyezelwa ukuthi abanye abantu ababili, owokuqala owaziwa ngokuthi “isiguli saseNew York” nowesibili ngokuthi “isiguli saseDolobheni Lethemba”, base beluleme ku-HIV nomdlavuza, ezingqungqutheleni zesayensi phakathi nonyaka odlule, bazi ukuthi imininingwane yokwelashwa kwabo akukakashicilelwa.

Nakuba ukufuna ikhambi le-HIV kwaqala kudala, ukufakelwa komnkantsha kuthathwa njengengozi kulesi simo, ngakho-ke kulungele inani elilinganiselwe leziguli ezihlushwa i-HIV kanye ne-leukemia ngesikhathi esifanayo.

Ukushintshashintsha okungajwayelekile

Ukuthola umnikeli womnkantsha onoguquko olungavamile ku-CCR5 gene kuyinselele enkulu.

“Ngesikhathi sokufakelwa kabusha, wonke amasosha omzimba esiguli athathelwa indawo yilawo onikelayo, okwenza ukuthi iningi lamangqamuzana atheleleke ngegciwane anyamalale,” kusho u-Asir Sass Sirion weFrench Pasteur Institute, ongomunye wocwaningo. ababhali.

Wanezela, "Inhlanganisela yazo zonke izici zokufakelwa kabusha ukuze kube ukwelashwa okuphumelelayo kwe-HIV kanye ne-leukemia kuyindaba engavamile."

Izibikezelo zika-Frank Hogrepet ziphinda futhi