Ukwelashwa kwezinduna namalunga ndawonye!!!

Ukwelashwa kwezinduna namalunga ndawonye!!!

Ithimba lososayensi abafuna ukwelashwa okusha kwe-osteoarthritis yesandla selifinyelele empumelelweni entsha ethembisayo ngesikhathi sokuhlolwa kwesidakamizwa esakhelwe ukwelapha induna kanye ne-psoriasis.

Ososayensi bakwazi nokuthola ukuthi umuthi ungavimbela ukuthuthukiswa kwe-osteoarthritis yesandla kumamodeli ezilwane zaselabhorethri, futhi njengamanje basebenzela abantu ukuze baqinisekise amandla ayo njengokwelashwa okusha komtholampilo, ngokusho kwalokho okwashicilelwa i-New Atlas, ecaphuna. iphephabhuku iScience Translational Medicine.

i-retinoic acid

Ucwaningo lwenziwe ososayensi baseNyuvesi yase-Oxford, abazimisele ukutadisha izinhlobo ezehlukene zofuzo olubizwa nge-ALDH1A2 oluxhunyaniswe ne-OA yesandla esinzima. Abacwaningi baqinisekise lesi sixhumanisi ngokudweba idatha evela ku-UK Biobank Study, base bethola i-articular cartilage ezigulini ezingama-33 ze-OA ngenkathi zihlinzwa.

Lawa masampuli aphinde acwaningwa kanye namamodeli okuhlola, okwenze ithimba likwazi ukuhlonza i-molecule ethile eyayiphansi kakhulu kubantu abasengozini enkulu. I-molecule ibizwa nge-retinoic acid, futhi yenziwa isakhi sofuzo se-ALDH1A2. Ngokulandelana kwe-RNA, abacwaningi bakwazi ukuthola ukuhlobana phakathi kokuhlukahluka kofuzo, i-retinoic acid ephansi, nokuvuvukala okubonwe ku-OA.

Izinduna kanye psoriasis

Abacwaningi babe sebephendukela emuthini obizwa ngokuthi i-Talarozole, owakhelwe ukuvimbela i-metabolism ye-retinoic acid ukwelapha izinduna, i-psoriasis kanye nezimo zesikhumba ezihlobene. Lapho isetshenziswa emalungeni amadolo amamodeli egundane, lesi sidakamizwa sikwazi ukunciphisa ukulimala kwe-cartilage nokuvuvukala ngemva kwamahora ayisithupha. Imiphumela iphinde yaphindwa kumajoyinti e-ex vivo porcine.

I-Osteoporosis nobuhlungu obungapheli

UDkt Neha Essar-Brown, umbhali kanye naye walolu cwaningo kanye noMqondisi we-Health Research e-Oxford University, uthe: "Ucwaningo lusesesigabeni sokuqala, kodwa ngale miphumela ekhuthazayo, siyisinyathelo esikhulu esiseduze ukuze sikwazi ukuthuthukisa. ikilasi elisha lemithi yokwelapha yokwelapha i-osteoporosis.

Ngenxa yokuthi i-talarozole inephrofayili yokuphepha eyamukelekayo kubantu, ososayensi babeka amathemba amakhulu endleleni eshelelayo yokusetshenziswa emtholampilo. Benza olunye ucwaningo oluncane lobufakazi bomqondo ukuze babone ukuthi le miphumela yokuqala ingaphindaphindwa yini, babeka isisekelo sendlela entsha yokwelapha ku-OA.

okuhlosiwe kwebhayoloji

Futhi, uDkt. Essar-Brown wanezela, “Kunesidingo esiphuthumayo semithi yokwelapha eklanyelwe ukuvimbela noma ukubuyisela emuva izimpawu ezibuhlungu ze-rheumatoid arthritis. Lolu cwaningo luveza ukuqonda okusha kwezimbangela ze-osteoarthritis yesandla, okungaholela ekuhlonzweni kwezinhloso ezintsha zebhayoloji ukuze kungenelele lapho kufinyeleleke khona i-OA."