Indlela yokumelana namacala okubanda nokubanda?

Indlela yokumelana namacala okubanda nokubanda?

Lapho kufika ubusika, amagciwane aqala ukusabalala ohlelweni lokuphefumula, kuyilapho izici ezikhuthaza ukutheleleka phakathi kwazo zivela, isibonelo, inani elikhulu lemibuthano ngaphakathi kwezindawo ezivaliwe lapho amagciwane ahlala khona kangcono, njengoba umoya ongaphakathi womile. Kodwa kwakungaqinisekiswanga ukuthi izinga lokushisa eliphansi liyawenza buthaka isimiso somzimba sokuzivikela ezifweni, futhi uma kunjalo, lokhu kwenziwa kanjani.

Ucwaningo olushicilelwe ngoLwesibili ku-Journal of Allergy and Clinical Immunology luhlole indlela entsha umzimba ohlasela ngayo amagciwane futhi isebenza kangcono uma kufudumele.

UMansour Amiji, uprofesa eNyuvesi yaseNortheastern, owabhala ngokuhlanganyela lolu cwaningo, utshele abe-AFP ukuthi lokhu okutholakele kungasiza ekwakheni izindlela ezintsha zokwelapha umkhuhlane namanye amagciwane.

Umsebenzi wocwaningo uqhamuke ocwaningweni lwangaphambilini olwenziwe ngu-Amiji ngonyaka ka-2018, oluthole ukuthi amaseli ekhala akhulula ama-extracellular vesicles, iqembu lama-molecule amancane ahlasela amagciwane lapho kufakwa umoya.

“Isifaniso esihle kakhulu sale nqubo isidleke samaju,” kuphawula u-Ameji. Njengeminyovu evikela isidleke sazo uma kwenzeka ihlaselwa, amasaka andiza aphume esitokisini ngamaqembu, abese enamathela kumagciwane futhi awabulale.

Abacwaningi bazibuze imibuzo emibili: Ingabe ukugcinwa kwama-vesicles e-extracellular nakho kuqoshwa ebukhoneni begciwane? Futhi uma kunjalo, ingabe ukusabela kwayo kuthonywa izinga lokushisa?
Ekuhlolweni kwabo, ososayensi basebenzisa ulwelwesi lwamafinyila ekhaleni lamavolontiya (abehlinzwa ukuze asuse ama-polyps) kanye nento lapho ukutheleleka ngegciwane kwanda khona.
Umphumela waba inani elihle lama-extracellular vesicles akhishelwe ukuhlasela amagciwane.

"Incazelo Yokuqala Ekholisayo"

Ukuze uphendule umbuzo wesibili, ulwelwesi lwamafinyila emakhaleni lwahlukaniswa lwaba amaqembu amabili, athuthukiswa elabhorethri, owokuqala angama-37 degrees Celsius, kanti owesibili angama-32 degrees Celsius.

Amazinga okushisa amabili akhethwe ngokusekelwe ekuhloleni okubonisa ukuthi izinga lokushisa ngaphakathi kwekhala lehla cishe ngo-5°C lapho izinga lokushisa lomoya wangaphandle lehla lisuka ku-23°C liya ku-4°C.

Ngaphansi kwezimo zokushisa komzimba ezijwayelekile, ama-extracellular vesicles akwazi ukulwa namagciwane kahle, ngokuwanikeza "ama-decoys" lapho amagciwane abambelela khona, kunokuba abe nama-cell receptors ayevame ukuwakhomba.

Kodwa njengoba amazinga okushisa aphansi, ama-vesicle ambalwa akhishwa ngaphandle kwengqamuzana futhi ayengasebenzi kahle ngokumelene namagciwane abawahlolile, okuyizinhlobo ezimbili zama-rhinoviruses kanye ne-coronavirus (non-Covid), evame kakhulu ebusika.

UBenjamin Blair, umbhali kanye naye wocwaningo kanye nodokotela ohlinzayo eHarvard Medical School, uthi, “Asikho isizathu esiqinisekisayo esiye sabhalwa ukuchaza ukwanda okucacile kwezifo ezibangelwa amagciwane phakathi nezinyanga ezibandayo,” ephawula ukuthi imiphumela yocwaningo imele “ Incazelo yokuqala eqinisekisayo yobuningi nebhayoloji okufinyelelwa kuyo.” .

UMansour Ameji uphawula ukuthi imiphumela yocwaningo ingaholela ekwakhiweni kwezindlela zokwelapha ukukhuthaza ukukhiqizwa kwemvelo kwama-extracellular vesicles, ngenhloso yokulwa kangcono nomkhuhlane ngisho nomkhuhlane kanye ne-Covid-19, wengeza, “Le ndawo yezintshisekelo zocwaningo. nathi kakhulu, futhi ngokuqinisekile sizoqhubeka nokusebenza kukho.”