Kuyini ukuxhumana phakathi kwezifo zesistimu yokugaya kanye nengqondo?

Kuyini ukuxhumana phakathi kwezifo zesistimu yokugaya kanye nengqondo?

Ucwaningo lwakamuva lwezilwane lubonise ukuthi isifo se-Alzheimer singadluliselwa kumagundane amancane ngokudluliswa kwamagciwane e-gut, okuqinisekisa ukuxhumana phakathi kwesistimu yokugaya kanye nempilo yobuchopho, ngokusho kwalokho okushicilelwe iwebhusayithi ye-Science Alert, ecaphuna iphephabhuku Imibiko Yesayensi.

Umphumela omubi wokuvuvukala

Ucwaningo olusha lwengeza ukwesekwa okwengeziwe embonweni wokuthi ukuvuvukala kungase kube indlela yokuba nomthelela omubi empilweni yobuchopho.” “Kutholwe ukuthi abantu abanesifo i-Alzheimer bavuvuka kakhulu amathumbu,” kusho isazi sokusebenza kwengqondo uBarbara Bendlin wase-University of Wisconsin. “Ukuthwebula ubuchopho, labo abanokuvuvukala okuphezulu emathunjini babe namazinga aphezulu e-amyloid [protein clumps] ebuchosheni babo.”

Ukuhlolwa kweCalprotectin

UMargo Heston, udokotela wezifo eNyuvesi yaseWisconsin, kanye nethimba labacwaningi bamazwe ngamazwe bahlola i-fecal calprotectin, umaka wokuvuvukala, kumasampula ezindle kubantu abangu-125 abakhethwe ezifundweni ezimbili zokuvimbela isifo i-Alzheimer's. Ababambiqhaza benze izivivinyo ezimbalwa zokuqonda kwengqondo lapho babhaliswa ocwaningweni, ngaphezu kwezingxoxo zomlando womndeni kanye nokuhlolwa kofuzo oluyingozi kakhulu lwe-Alzheimer's. Isethi engaphansi iye yahlolelwa izimpawu ze-amyloid protein clumps, inkomba evamile yesifo esibangela isimo se-neurodegenerative. Nakuba amazinga e-calprotectin ngokuvamile ayephakeme ezigulini esezikhulile, ayegqama kakhulu kulabo abanama-amyloid plaque uphawu lwesifo i-Alzheimer's.

Inkumbulo ye-Alzheimer noma ebuthakathaka

Amazinga ezinye izimpawu eziphilayo zesifo i-Alzheimer's nawo anda ngamazinga okuvuvukala, futhi nezibalo zokuhlolwa kwenkumbulo zehla njengoba i-calprotectin nayo ikhuphuka. Ngisho nabahlanganyeli abangatholakalanga benesifo i-Alzheimer's babenezibalo ezingezinhle zenkumbulo ezinamazinga aphezulu e-calprotectin.

Izinguquko ku-bacterial gut

Ukuhlaziywa kwelabhorethri kuye kwabonisa ngaphambilini ukuthi amakhemikhali avela kubhaktheriya yamathumbu angavusa izimpawu zokuvuvukala ebuchosheni. Ezinye izifundo zithole ukwanda kokuvuvukala kwamathumbu ezigulini ze-Alzheimer's uma kuqhathaniswa neqembu lokulawula.
U-Heston nozakwabo basikisela ukuthi izinguquko ku-microbiome ziholela ekushintsheni emathunjini okuholela ekuvuvukeni ezingeni lesistimu. Lokhu kuvuvukala kuncane kodwa akupheli, futhi kubangela umonakalo ocashile noqhubekayo ogcina uphazamisa ukuzwela kwezivimbi zomzimba.

Umgoqo wegazi-ubuchopho

"Ukwenyuka kwamathumbu emathunjini kungaholela emazingeni aphakeme ama-molecule avuvukalayo kanye nobuthi obutholakala ku-lumen yamathumbu egazini, okuholela ekuvuvukeni kwesistimu, okungase kwenze buthaka umgoqo wegazi-ubuchopho futhi kungase kukhuthaze ukuvuvukala," kusho uFederico Re, uprofesa. ye-bacteriology e-Wisconsin State University. nerve, [ngaleyo ndlela ibangela] ukulimala kwemizwa kanye ne-neurodegeneration.”

Izinguquko zokudla

Abacwaningi njengamanje bazama amagundane aselabhorethri ukuze babone ukuthi izinguquko ekudleni okuhambisana nokwanda kokuvuvukala zingavusa inguqulo yesifo i-Alzheimer kumagundane.
Naphezu kwamashumi eminyaka ocwaningo, akukabikho ukwelashwa okusebenzayo kwezigidi zabantu abanesifo i-Alzheimer's emhlabeni wonke. Kodwa ngokuqonda okwengeziwe kwezinqubo zebhayoloji, ososayensi baya ngokuya besondela.

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