Buyini ubudlelwano besimo somzwelo se-Irritable Bowel Syndrome?

Buyini ubudlelwano besimo somzwelo se-Irritable Bowel Syndrome?

I-IBS ivame ukuhambisana nezimpawu zesisu emathunjini amancane namakhulu. I-IBS yahlukaniswa yaba ama-subtypes amane kuye ngokuthi i-stool asymmetry i.e. I-IBS ene-IBS-C yokuqunjelwa, enesifo sohudo IBS-D, i-IBS-M exutshwe, noma i-IBS engacaciswanga.

Kodwa-ke, kukhona ukuntula ukuqonda ezincwadini zesayensi mayelana nezinqubo nokwelashwa kwe-IBS, isizathu esisodwa esiwukuntuleka kwamamodeli ezilwane okuhlola awusizo.

Ngokuhamba kweminyaka, ucwaningo luye lwaphakamisa ukuxhumana phakathi kwezimo zemizwa kanye nokungasebenzi kahle kwamathumbu, kugcizelela ubukhona nokubaluleka kwalokho okubizwa ngokuthi “i-gut axis” ekunqumeni ubuqotho bomzwelo nokudla okumelela.

Ukucindezeleka kokuhlulwa komphakathi

Muva nje, izingcindezi ze-cSDS nezingcindezi ze-cVSDS zamukelwa njengamamodeli we-MDD ne-PTSD.

Ukuphendula umbuzo othi, “Ingabe izibonelo zezilwane zokuhlulwa kwesikhashana okungapheli zingasisiza siqonde i-IBS ngokuningiliziwe?” abacwaningi base-TUS, abaholwa nguSolwazi Akiyoshi Saitoh weSikole Sesayensi Yemithi, basebenzisa amamodeli wamagundane ukuze baqonde imiphumela yokucindezeleka isikhathi eside esifo. .amathumbu.

Abacwaningi bathola ukuthi amagundane acindezeleke kakhulu abonisa ukuhamba kwamathumbu aphezulu kanye nokuziphatha okuhlobene nobuhlungu be-visceral, okuyizimpawu ze-IBS.

ukucindezeleka ngokomzimba noma ngokomzwelo

USolwazi Saitoh uthi phakathi nocwaningo, kugxilwe “kwimodeli yokuhlulwa kwesikhashana okungapheli, futhi umphumela wokucindezeleka ngokomzwelo ezifweni zamathumbu wahlolwa, ngaphezu kokuhlola amandla emodeli njengemodeli entsha yezilwane ye-Irritable Bowel Syndrome.”

Ocwaningweni lwabo, abacwaningi bafaka amagundane ekucindezelekeni ngokomzimba noma ngokomzwelo Izilwane zokuhlola zabhekana nokuhlukunyezwa ngokomzimba noma kwengqondo imizuzu engu-10 ngosuku izinsuku ezingu-10 ezilandelanayo.

ukuhlolwa kokuxhumana komphakathi

Ngosuku lweshumi nanye, ukuhlolwa kokuxhumana komphakathi kwenziwa ukuze kuhlolwe izimo zokucindezeleka zezilwane zokuhlola. Ukukhathala nakho kwalinganiselwa ngokulinganisa inani le-corticosterone ku-plasma nokuhlola indlela yokudla kwamalahle emathunjini. Abacwaningi baphinde bahlola amagundane ukuthi angakwazi yini ukungena emathunjini, imvamisa yokuthulula, kanye nokuqukethwe kwefecal.

Kutholakale ukuthi izinga lokuhamba kwamalahle, elibonisa ukudlula emathunjini, laliphezulu kakhulu kumagundane angaphansi kokucindezeleka ngokomzwelo uma kuqhathaniswa namagundane eqenjini lokulawula, elingazange livezwe ekucindezelekeni. Kodwa imiphumela yayimincane kumagundane, ayengaphansi kokucindezeleka ngokomzimba. Ukuvama kokuzikhulula kanye nokuqukethwe kwamanzi esitokisini nakho kwanda kumagundane abhekene nokucindezeleka ngokomzwelo.

Izimpawu ezifana ne-Irritable Bowel Syndrome

Le miphumela yaqhubeka inyanga ye-XNUMX ngemuva kokuchayeka ekucindezelekeni, ngaphezu kwalokho kwakungekho umehluko omkhulu esimweni se-pathological kanye nokuqina kwamathumbu phakathi kwamagundane eqembu lokulawula noma iqembu elicindezelekile ngokomzwelo, okubonisa ukungabikho kwezinguquko ezingeni lezicubu ngenxa yokucindezeleka. .

"Imiphumela ibonisa ukuthi ukucindezeleka okungapheli kumagundane kubangela izimpawu ze-IBS-D-D-like, ezifana nokuhlukunyezwa okungapheli kwamathumbu kanye ne-abdominal hyperalgesia, ngaphandle kokuba khona kwezilonda emathunjini," kusho uProfesa Saitoh.

Inothi elimangalisayo

Kuyathakazelisa ukuthi abacwaningi bathola ukuthi izinguquko ekuhambeni kwamathumbu ezilwaneni zokuhlola zaba ngcono lapho amagundane emodeli ye-cVSDS ephathwa ngomuthi osetshenziswa emtholampilo we-IBS.

Ucwaningo lugqamisa inzuzo yemodeli ye-cVSDS kunezindlela zendabuko zokwehlisa izimpawu ezifana ne-IBS-D ngokuchayeka ekucindezelekeni okungokwengqondo okuphindaphindayo.

Indima ye-cerebral cortex

Ekhuluma ngezinqubo zale miphumela, uProf. Saitoh uthi: “Kusukela ku-axis yamathumbu nobuchopho, kungenzeka ukuthi i-cerebral cortex idlala indima ebalulekile ekunqumeni uhlobo lwamagundane acindezeleke ngokomzwelo.” I-insular cortex iyingxenye yesimiso sezinzwa esiphezulu esiphezulu esilawula imisebenzi yokugaya futhi ihileleke ohlelweni lokubhekana nokucindezeleka.

Ngaphezu kwalokho, ucwaningo lubonisa, ngokokuqala ngqa, ukuthi ukucindezeleka kwengqondo okubangelwa i-cVSDS kuphela kungabangela izimpawu ezifana ne-IBS-D kumagundane, ngakho-ke ucwaningo olwengeziwe lwamamodeli we-cSDS engapheli kanye ne-cVSDS lungacacisa ngokuningiliziwe mayelana nezimo ze-pathophysiological kanye ngaleyo ndlela aklame ukwelashwa kwe-Irritable Bowel Syndrome.