Ukwelashwa okuthembisayo kulabo abahlushwa izinhlungu ezingezansi

Ukwelashwa okuthembisayo kulabo abahlushwa izinhlungu ezingezansi

Ososayensi baseCedars-Sinai Medical Centre baye bahlonza i-subset entsha yamaseli ngaphakathi kwe-intervertebral discs ewohlokayo, efana ne-jelly kubantu abanobuhlungu obuphansi emuva. Lamangqamuzana awabonakali kubantu abanama- intervertebral disc anempilo noma ama-disc awonakele ngaphandle kokuzwa ubuhlungu, ngokwe-New Atlas, ecaphuna iphephabhuku i-Science Translational Medicine.

Amaseli kumgogodla wangemuva

Umcwaningi oholayo uDkt. Dmitry Shein, usosayensi wocwaningo e-Cedars-Sinai Center, uthe yena nethimba lakhe labacwaningi baphumelele “ekuboneni okokuqala ngqa amangqamuzana athile angaba yisihluthulelo sokuqonda ubuhlungu” kumgogodla womgogodla, ephawula ukuthi "ukwazi okwengeziwe ngokuthi la maseli asebenza kanjani kungaholela... "Ekugcineni ekutholeni izindlela ezintsha zokwelapha."

Ocwaningweni, abacwaningi balingisa izimo eziwohlokayo kuma-vertebrae futhi baguqula amaseli akhulisiwe abe yi-subtype yeseli ehlobene nobuhlungu esanda kutholwa. Abacwaningi baphinde bakha amaseli ekamelweni elilodwa le-chip enamagumbi amabili. Kwelinye igumbi, bafaka ama-neuron akhombisa izinhlungu ayedalwe ngama-stem cells.

Amangqamuzana obuhlungu

Abacwaningi bathola ukuthi lapho amangqamuzana ahlobene nobuhlungu ekhona ocezwini, ama-neurons egunjini lesibili akhula ama-axon - inethiwekhi ene-fibrous lapho amasignali adluliselwa khona - ebheke kumaseli ezinhlungu. Kodwa alukho ushintsho ekwakhekeni kwama-neurons lapho amangqamuzana anempilo esegumbini elilandelayo.

UDkt. Shen uthe namanje akwaziwa “ukuthi amangqamuzana ahlobene nobuhlungu aheha ama-neurons ahlaselayo, noma amangqamuzana anempilo ayawaxosha, kodwa ukhona umehluko phakathi kwamangqamuzana anempilo namangqamuzana ahlobene nobuhlungu.”

Ukuhlasela kwe-nerve endings

Ngenxa yokuthi azikho iziphetho zemizwa kuma-intervertebral discs, ukuwohloka kwawo akusho ukuthi kuholele ebuhlungu obuphansi emuva. Kodwa lapho izinto zokudonsa umgogodla ziguga futhi zome, izicubu ezizungezile zingaphazamisa.

"Ngezinye izikhathi, lapho ama-disc ewohloka, iziphetho zezinzwa ezivela ezicutshini ezizungezile zihlasela i-disc, [okungaba isizathu sokuzwa] ubuhlungu," kuchaza uDkt Shen.

Ukutholwa okujabulisayo

Ukutholakala kuyajabulisa njengoba kungase kuholele ekukhetheni okubalulekile kokwelashwa mayelana ne-40% yabantu abadala abahlushwa ubuhlungu obuphansi emuva ngenxa yokuwohloka kwama-vertebrae.

Abacwaningi bacabanga ukuthi izinketho zokwelapha zingabandakanya ukuhlela kabusha amaseli ahlobene nobuhlungu noma ukugcwalisa ama-discs ngamaseli anempilo ukuze anqobe amaseli enkinga.

"Ngokuqondile ukuqondisa i-cell subtype" embi "noma ukugcwalisa i-cell subtype 'enhle' kungase kunikeze amasu awusizo ekwelapheni ubuhlungu obuphansi be-vertebra-based back back," kusho uClive Svendsen weCedars-Sinai, ephawula ukuthi "imiphumela yocwaningo ibonisa ukufaneleka" Ulwazi oluthile lwe-classical spine noma i-pain biology ingaba isinyathelo esibheke ekwelapheni kwamaseli okuhlosiwe okubhekana nezimbangela zobuhlungu obuphansi emuva. "

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