Izimbangela ezinamandla ezikhuthazayo zezifo zemizwa kanye ne-Alzheimer's

Izimbangela ezinamandla ezikhuthazayo zezifo zemizwa kanye ne-Alzheimer's

Ucwaningo lwakamuva lwesayensi lubonise ukuthi ezinye izifo ezibangelwa amagciwane zingaba nomthelela ezifweni ze-neurodegenerative ezifana nesifo i-Alzheimer's nesifo sika-Parkinson.

Ucwaningo, olushicilelwe yiwebhusayithi yezempilo ye-Boldsky, lucaphuna iphephabhuku le-Nature Communications, lusekelwe ocwaningweni lwaselabhorethri olwabonisa ukuthi izinhlayiya ezithile zegciwane zenza kube lula ukusabalala kwamaqoqo amaprotheni anguphawu lwezifo zobuchopho.

Isifo se-Prion

Ithimba labacwaningi, abavela eNyuvesi yaseBonn, eJalimane, laqaphela ukuthi amaqoqo amaprotheni ahlanekezelwe, okwenzeka kulokho okubizwa ngokuthi isifo se-prion, anekhono lokusuka kwelinye ingqamuzana ukuya kwelinye, lapho edlulisela isimo sawo esingavamile kumaprotheni. yohlobo olufanayo.

Ngenxa yalokho, lesi sifo sibhebhetheka ebuchosheni, kusho abacwaningi, nokuthi kwenzeka okufanayo nasesifo i-Alzheimer kanye nesifo sikaParkinson. Ukudluliswa kwama-aggregate kungabandakanya ukuxhumana okuqondile kweseli kuya kuseli, ukukhululwa kwama-agglomerate “enqunu” endaweni engaphandle kwamangqamuzana noma amaphakheji kuma-vesicle, okungamabhamuza amancane azungezwe i-lipid sheath efihlelwa ukuxhumana phakathi kwamaselula.

"Izindlela eziqondile zokudlulisela azaziwa," kusho uProf. Anna Voorberg, uprofesa eNyuvesi yaseBonn.

Ukulingisa imiphumela yokutheleleka ngegciwane

Ukulingisa okwenzeka ngenxa yokutheleleka ngegciwane, abacwaningi bashukumise amaseli ukuthi akhiqize amaprotheni egciwane alamula ukubopha kwamaseli okuhlosiwe kanye nokuhlanganiswa kwe-membrane.
Kukhethwe izinhlobo ezimbili zamaprotheni okuhlanganisa iphrotheni eyisipike i-SARS-CoV-2, eqhamuka egciwaneni elibangela i-COVID-19, kanye ne-vesicular stomatitis virus VSV-G glycoprotein, eyenzeka kumagciwane ezinkomo nezinye izilwane.

Amaseli azwakalise ama-receptors alawa maprotheni angama-viral, umndeni wama-receptor we-LDL, osebenza njengezindawo zokuzinza kwe-VSV-G, kanye nesamukeli se-ACE2, isamukeli sakwaSARS-CoV-2.

"Singakhombisa ukuthi amaprotheni egciwane afakwe kulwelwesi lwamaseli kanye nama-vesicles angaphandle," kusho uSolwazi Forberg.

Ubuye wengeza ngokuthi "ukuba khona kwayo kukhulisa ukusabalala kokunqwabelana kwamaprotheni phakathi kwamaseli, kungaba ngokuthintana namaselula okuqondile noma ngama-vesicle angaphandle."

Ama-viral ligands alamula ukudluliswa okuphumelelayo kwezilinganiso kumaseli abamukeli, lapho avuselela khona izilinganiso ezintsha. "Izixhumanisi zisebenza njengamaswishi avula amaseli abamukeli futhi ngaleyo ndlela angenele amaphuzu ayingozi," kusho uSolwazi Forberg.

Ukusebenzisana kwe-Virus protein receptor

Sekukonke, idatha iphakamisa ukuthi ukusebenzisana kwe-viral ligand-receptor empeleni kungathonya ukudluliswa kwamaprotheni e-pathogenic.

UProfesa Forberg wathi: “Ubuchopho beziguli ezinezifo ezithinta imizwa ngezinye izikhathi buqukethe amagciwane athile. Kusolakala ukuthi abangela ukuvuvukala noma anomthelela onobuthi, futhi ngaleyo ndlela asheshise inqubo yokuwohloka kwemizwa,” kuphawula ukuthi “amaprotheni anegciwane angenza ngendlela ehlukile, njengoba engaphumela ekwandeni kokwanda kwamaqembu amaprotheni asevele ekhona ezifweni ze-neurodegenerative.” Njengokungathi Isifo i-Alzheimer's.

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