Ƙirƙirar kimiyya don magance cututtukan zuciya

Ƙirƙirar kimiyya don magance cututtukan zuciya

A cikin sabon bincike mai zurfi, masana kimiyya za su sake rubuta DNA da manufar gano maganin farko a duniya game da cututtukan zuciya na kwayoyin halitta, a cikin abin da za a iya kwatanta shi a matsayin "lokaci mai mahimmanci" a fannin likitancin zuciya.

Bisa ga abin da shafin yanar gizon "Boldsky" ya buga, masana kimiyya masu jagorancin duniya daga Birtaniya, Amurka da Singapore sun haɗu a kan aikin "Cure Heart" don tsara maganin rigakafi ga masu ciwon zuciya. Rahotannin da ke fitowa daga kafafen yada labarai na cewa, Gidauniyar Zuciya ta Biritaniya ta sadaukar da Yuro miliyan 30 don wannan aikin na ceton rai.

A karon farko, masu bincike za su yi amfani da ingantattun dabarun ƙwayoyin halitta, waɗanda aka fi sani da gyare-gyare na asali, a cikin zuciya don ƙira da kuma gwada maganin farko na cututtukan ƙwayoyin tsokar zuciya da aka gada, da nufin kawo cikas ga ƙwayoyin halittar da ba su da kyau.

Ciwon zuciya na gado

“Cutar zuciya ta gado” kalma ce da ta kunshi dukkan cututtukan zuciya da iyaye ke yadawa zuwa ga ‘ya’yansu, watau idan daya ko duka biyun suna da nakasu ko nakasu, akwai yiwuwar isar da shi ga yara 50/50. Wasu cututtukan zuciya da aka gada sun haɗa da hypertrophic cardiomyopathy da hypercholesterolemia.

Wasu masu ciwon zuciya na gado maiyuwa ba su da alamomi da yawa, kuma ba a gano cutar ba sai bayan bugun zuciya, suma, ko mutuwa kwatsam. Kididdiga ta nuna cewa kusan kashi 0.8 zuwa 1.2% na jarirai a duniya suna fama da cututtukan zuciya na kwayoyin halitta.

Damar tarihi da shekaru 30 na bincike

Wani kwamitin ba da shawara karkashin jagorancin Farfesa Sir Patrick Vallance, babban mashawarcin kimiyya ga gwamnatin Burtaniya, ya zabi tawagar da ke da alhakin gudanar da bincike mai mahimmanci, yayin da Farfesa Hugh Watkins, daga Jami'ar Oxford kuma babban mai bincike kan aikin Cure Heart, ya ce ciwon zuciya. cuta ce mai tsanani.Hakika yanayin "na kowa" a duk duniya kuma an san yana shafar 250 cikin mutane XNUMX.

Farfesa Watkins ya kara da cewa, yana bayyana binciken a matsayin "dama na lokaci daya a cikin tsararraki" da nufin rage damuwa da ke gudana game da mutuwar kwatsam, raunin zuciya da yiwuwar buƙatar dashen zuciya.

Farfesa Watkins ya bayyana cewa, "Bayan shekaru 30 na bincike, an gano wasu takamaiman kwayoyin halitta da lahani na kwayoyin halitta wadanda ke da alhakin cututtuka daban-daban na zuciya da kuma yadda suke aiki. An yi imanin cewa za a sami hanyar maganin kwayoyin halitta don fara gwaji da gwaji a cikin shekaru biyar masu zuwa."

Gyaran kwayoyin halitta marasa lahani

Ana fatan sabon shirin na binciken zai gyara maye gurbi na kwayoyin halitta da ke haddasa matsalolin zuciya har abada.

A cikin wannan mahallin, Christine Seidman, farfesa a Makarantar Kiwon Lafiya ta Harvard kuma jagorar mai binciken da ke cikin aikin, ta bayyana cewa manufar ita ce "gyara zukata" da kuma maido da aikinsu na yau da kullun, yana mai bayyana cewa "mafi yawan maye gurbi da suka bayyana a tsakanin marasa lafiya suna jagoranci. canza harafi ɗaya akai-akai. Daga lambar DNA, wanda ke nufin cewa akwai magani ta hanyar canza monogram da dawo da lambar.

A cewar masu binciken, majagaba daga nahiyoyi uku da suka yi fice a fannin litattafai da kuma gyaran kwayoyin halitta masu inganci da ke cikin binciken, har yanzu ba a gudanar da gwaje-gwajen dan Adam ba, amma gwajin dabbobi ya yi nasara da kuma cika alkawari.

Masu binciken sun kara da cewa, ana sa ran mutanen da ke fuskantar barazanar kamuwa da cututtukan zuciya ta kwayoyin halittarsu sakamakon samuwar kwayoyin halittar da ba su da kyau a cikin iyalansu za su iya samun magani kafin cutar ta taso.