Puas noj nqaij ntau dhau ua rau mob qog noj ntshav?

Puas noj nqaij ntau dhau ua rau mob qog noj ntshav?

Ib pab pawg kws tshawb fawb hauv Tebchaws Meskas tau ua tiav hauv kev tshawb nrhiav qhov sib txuas ntawm kev noj cov nqaij liab thiab ua tiav thiab qhov tshwm sim ntawm mob qog noj ntshav hauv plab.

Cov kws tshawb fawb pom ob lub cim caj ces uas yuav piav qhia txog qhov muaj feem yuav mob qog noj ntshav, tab sis tsis yog nws lub hauv paus. Nkag siab txog cov txheej txheem kab mob thiab cov noob caj ces tom qab nws tuaj yeem pab tsim cov tswv yim tiv thaiv zoo dua.

Qhov tshwm sim ntawm kev mob plab hnyuv

Raws li qhov tau tshaj tawm los ntawm New Atlas, suav nrog phau ntawv xov xwm Cancer Epidemiology, Biomarkers & Tiv Thaiv, mob qog noj ntshav hauv plab, tseem hu ua mob qog noj ntshav, yog hom thib peb feem ntau mob qog noj ntshav thiab thib ob ua rau mob qog noj ntshav thoob ntiaj teb. Nws kuj tseem nce ntxiv rau cov neeg hluas, nrog rau American Cancer Society ACS tshaj tawm tias 20% ntawm kev kuaj mob hauv 2019 yog nyob rau hauv cov neeg mob hnub nyoog qis dua 55, uas yog ze li ob npaug ntawm tus nqi hauv xyoo 1995.

Lub predominant lom mechanism

Txawm hais tias kev koom tes ntawm cov nqaij liab thiab cov nqaij ua tiav thiab kev mob qog nqaij hlav hauv plab tau paub txog qee lub sijhawm, cov txheej txheem lom neeg tseem ceeb hauv qab nws tsis tau txheeb xyuas. Hauv ib txoj kev tshawb fawb tshiab, cov kws tshawb fawb los ntawm University of Southern California tau tshawb pom tias ob yam genetic yam hloov pauv kev pheej hmoo mob qog noj ntshav raws li kev noj cov nqaij liab thiab ua tiav.

Ib pab pawg ntsib kev pheej hmoo ntau dua

"Cov txiaj ntsig tau qhia tias muaj ib pawg neeg ntawm cov neeg uas muaj kev pheej hmoo ntau dua los ntawm kev mob qog noj ntshav hauv plab yog tias lawv noj cov nqaij liab lossis ua tiav," Mariana Stern, tus thawj coj ntawm kev tshawb fawb, sau tseg tias nws "tso kev pom rau hauv lub peev xwm txheej txheem tom qab. qhov kev pheej hmoo no, uas "Nws tuaj yeem ua raws li kev tshawb fawb sim."

Cov kws tshawb fawb tau soj ntsuam ib qho piv txwv ntawm 29842 tus neeg mob qog nqaij hlav hauv plab thiab 39635 kev tswj hwm ntawm European keeb kwm los ntawm 27 txoj kev tshawb fawb. Lawv thawj zaug siv cov ntaub ntawv los ntawm cov kev tshawb fawb los tsim cov qauv ntsuas kev noj cov nqaij liab, nqaij nyug, yaj, thiab cov nqaij ua tiav xws li hnyuv ntxwm thiab deli nqaij.

Kev noj zaub mov txhua hnub rau txhua pab pawg tau suav thiab hloov kho raws li lub cev qhov ntsuas qhov ntsuas (BMI), thiab cov neeg koom tau muab faib ua plaub pawg raws li lawv qib kev noj cov nqaij liab lossis ua tiav. Cov neeg uas noj cov nqaij liab siab tshaj plaws thiab cov nqaij ua tiav yog 30% thiab 40% feem ntau yuav ua rau mob qog nqaij hlav hauv plab, feem. Cov txiaj ntsig no tsis suav nrog kev hloov pauv caj ces, uas tuaj yeem ua rau muaj kev pheej hmoo ntau dua rau qee tus neeg.

DNA cov qauv

Raws li cov qauv DNA, cov kws tshawb fawb tau sau cov ntaub ntawv rau ntau tshaj xya lab cov noob caj noob ces uas npog cov genome - tag nrho cov ntaub ntawv caj ces - rau txhua tus neeg koom nrog. Txhawm rau txheeb xyuas qhov kev sib raug zoo ntawm kev noj cov nqaij liab thiab kev pheej hmoo mob qog noj ntshav, kev soj ntsuam genome-wide gene-environment analysis tau ua. Cov kws tshawb fawb tau tshuaj xyuas SNPs, uas yog cov lus tshaj tawm thiab yog hom kev hloov pauv caj ces feem ntau, rau cov neeg koom los txiav txim siab seb puas muaj ib qho kev hloov pauv caj ces hloov qhov kev pheej hmoo ntawm mob qog noj ntshav rau cov neeg noj nqaij liab ntau dua. Tseeb, kev koom tes ntawm cov nqaij liab thiab mob qog noj ntshav tau hloov pauv hauv tsuas yog ob ntawm SNPs kuaj: SNP ntawm chromosome 8 nyob ze HAS2 noob thiab SNP ntawm chromosome 18, uas yog ib feem ntawm SMAD7 noob.

HAS 2 gene

HAS2 noob yog ib feem ntawm txoj hauv kev uas sau cov protein hloov hauv cov hlwb. Cov kev tshawb fawb yav dhau los tau txuas nws mus rau mob qog noj ntshav, tab sis tsis tau txuas nws mus rau kev noj nqaij liab. Cov kws tshawb fawb soj ntsuam tau pom tias cov neeg uas muaj qhov sib txawv ntawm cov noob pom nyob rau hauv 66% ntawm cov qauv muaj 38% kev pheej hmoo siab ntawm kev mob qog nqaij hlav hauv plab yog tias lawv noj cov nqaij siab tshaj plaws. Piv txwv li, cov neeg uas tsis tshua muaj qhov sib txawv ntawm tib lub noob tsis muaj kev pheej hmoo mob qog noj ntshav thaum lawv noj cov nqaij liab ntau dua.

SMAD7 noob

Raws li SMAD7 gene, nws tswj hwm hepcidin, cov protein cuam tshuam rau cov hlau metabolism. Khoom noj muaj ob hom hlau: heme hlau thiab tsis-heme hlau. Heme hlau yog yooj yim absorbed los ntawm lub cev, muaj txog li 30% ntawm nws absorbed los ntawm cov zaub mov noj. Vim tias cov nqaij liab thiab cov nqaij ua tiav muaj cov heme hlau siab, cov kws tshawb fawb tau pom tias cov SMAD7 cov noob sib txawv tuaj yeem ua rau muaj kev pheej hmoo mob qog noj ntshav los ntawm kev hloov lub cev ua hlau li cas.

Nce intracellular hlau

Stern tau hais tias "Thaum hepcidin yog dysregulated, nws tuaj yeem ua rau muaj kev nqus hlau ntau ntxiv thiab txawm tias muaj cov hlau intracellular ntxiv," Stern tau hais tias. % ntawm cov qog nqaij hlav hauv plab yog tias lawv noj cov nqaij liab siab. Thaum cov neeg uas tsuas muaj ib daim qauv ntawm ntau qhov sib txawv lossis ob daim ntawv luam ntawm qhov sib txawv tsawg dua tau muaj kev pheej hmoo mob qog noj ntshav ntau dua kwv yees li ntawm 7% thiab 74%, feem. Cov kws tshawb fawb vam tias yuav mus nrhiav kev tshawb fawb uas tuaj yeem ntxiv dag zog rau cov pov thawj ntawm lub luag haujlwm ntawm dysregulated hlau metabolism hauv kev loj hlob ntawm mob qog noj ntshav.

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